Homeobox C8 Proteins (HOXC8)

HOXC8 belongs to the homeobox family of genes. Additionally we are shipping Homeobox C8 Antibodies (67) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HOXC8 3224 P31273
HOXC8 15426 P09025
HOXC8 24460  
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Top Homeobox C8 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

HOXC8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Homeobox C8 (HOXC8) Interaction Partners

Xenopus laevis Homeobox C8 (HOXC8) interaction partners

  1. Cdx1 (show CDX1 Proteins) binds directly these responsive elements during embryogenesis, as part of the mechanism for (show CDX1 Proteins) the timely activation of HoxC8 expression.

Zebrafish Homeobox C8 (HOXC8) interaction partners

  1. Remodeling of Hox (show MSH2 Proteins) regulatory elements in different species has played a significant role in generating morphological diversity.

Human Homeobox C8 (HOXC8) interaction partners

  1. High expression of HOXC8 is associated with laryngeal squamous cell carcinoma.

  2. HOXC8 knockdown led to inhibition of tumor cell proliferation and migration in vitro by inhibiting MMP-9 (show MMP9 Proteins) expression and tumor growth in vivo. The results strongly suggest that HOXC8 is involved in the tumorigenesis of osteosarcoma and might serve as a novel predictor for patients' outcome.

  3. embigin (show EMB Proteins) is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors

  4. Ectopic expression of HoxC8 inhibits nasopharyngeal carcinoma cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes.

  5. Upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma.

  6. miR (show MLXIP Proteins)-196a was over-expressed in cervical cancer cells, while an absence of HOXC8 expression was observed.

  7. HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.

  8. HOXC8 can be used as a prognostic marker in esophageal squamous cell carcinoma

  9. HOXC8 expression is inversely related to pancreatic ductal adenocarcinoma progression and metastasis.

  10. a complex role for HOXC8 in prostate cancer, promoting invasiveness while inhibiting AR-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate

Mouse (Murine) Homeobox C8 (HOXC8) interaction partners

  1. In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (show HOXA1 Proteins), HoxA5 (show HOXA5 Proteins), HoxC4 (show HOXC4 Proteins) &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin (show INS Proteins) down regulates HoxA10 (show HOXA10 Proteins). T3 results in over expression of HoxA5 (show HOXA5 Proteins), HoxC4 (show HOXC4 Proteins) and HoxC8 genes, whereas insulin (show INS Proteins) up regulates expression of only HoxC8

  2. Hoxc8 initiates an ectopic mammary program by regulating Fgf10 (show FGF10 Proteins) and Tbx3 (show TBX3 Proteins) expression and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling

  3. Cdx1 (show CDX1 Proteins) regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx (show CDX1 Proteins) activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox (show MSH2 Proteins) sequential activation.

  4. Hoxc8 downregulates Mgl1 (show LLGL1 Proteins) tumor suppressor gene expression and reduces its concomitant function on cell adhesion.

  5. Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4 (show HOXD4 Proteins)-transgenic mice.

  6. Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 (show SMAD6 Proteins) promoter activity and its mRNA expression

  7. Hoxc8 regulation is essential for osteoblast differentiation.

  8. Pcna (show PCNA Proteins) is a direct downstream target of Hoxc8.

  9. interaction with smad1 (show SMAD1 Proteins) stimulates bone development

  10. remodeling of Hox (show MSH2 Proteins) regulatory elements in different species has played a significant role in generating morphological diversity

Homeobox C8 (HOXC8) Protein Profile

Protein Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.

Gene names and symbols associated with Homeobox C8 Proteins (HOXC8)

  • homeobox C8 (hoxc8)
  • homeobox protein pXhoxc8 (xhoxc8)
  • homeo box C8a (hoxc8a)
  • homeobox C8 (HOXC8)
  • homeobox C8 (Hoxc8)
  • cb341 protein
  • D130011F21Rik protein
  • Hox-3.1 protein
  • HOX3 protein
  • HOX3A protein
  • Hox3r4 protein
  • HOXC-8 protein
  • hoxc8 protein
  • MGC89609 protein
  • xhoxc8 protein
  • z-179 protein
  • zgc:91832 protein

Protein level used designations for Homeobox C8 Proteins (HOXC8)

homeobox C8 , homeo box C8 , homeobox protein pXhoxc8 , homeobox c8a , homeobox gene C-8 , homeobox protein Hox-C8a , Hox-3.1, mouse, homolog of , homeo box 3A , homeobox protein Hox-3A , homeobox protein Hox-C8 , homeobox protein Hox-3.1 , homeobox protein M31 , Homeobox gene C8 , homeobox protein R4 , cHoxc-8

448482 Xenopus (Silurana) tropicalis
100158353 Xenopus laevis
399084 Xenopus laevis
449648 Danio rerio
3224 Homo sapiens
607052 Canis lupus familiaris
100295249 Bos taurus
15426 Mus musculus
24460 Rattus norvegicus
395711 Gallus gallus
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