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Inositol Polyphosphate-5-Phosphatase, 145kDa Proteins (INPP5D)

INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Additionally we are shipping Inositol Polyphosphate-5-Phosphatase, 145kDa Antibodies (150) and Inositol Polyphosphate-5-Phosphatase, 145kDa Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
INPP5D 16331 Q9ES52
Rat INPP5D INPP5D 54259 P97573
INPP5D 3635 Q92835
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Top Inositol Polyphosphate-5-Phosphatase, 145kDa Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

INPP5D Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Interaction Partners

Zebrafish Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

  1. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a (show INPP4A Proteins), and accelerates phagosome acidification

  2. Data (including data from studies in knockout mice) suggest that up-regulation of signaling in colonic mucosa via interleukin-10 (show IL10 Proteins)/microRNA-155/SHIP-1 (Src homology 2 domain-containing inositol-5-phosphatase) is involved in development of colitis due to dysbiosis.

  3. Our results describe a critical role for SHIP-1 in regulating the ability of dendritic cells to efficiently prime Th2-type responses.

  4. Findings indicate a role for inositol-polyphosphate 5-phosphatase SHIP-1 coupling to DC-type lectin receptor ectin-1 hemITAM in the selective control of downstream responses.

  5. miR (show MLXIP Proteins)-155 regulates the delicate balance between PAK1 (show PAK1 Proteins)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

  6. miR (show MLXIP Proteins)-155 regulation of SHIP represents a unique axis that regulates dendritic cells function in vivo.

  7. SHIP1 and Csk (show CSK Proteins) are part of the PSTPIP2 (show PSTPIP2 Proteins)-dependent inhibitory network that prevents the development of autoinflammatory disease.

  8. intracellular signaling by SHIP1 in mesenchymal stem cells is critical for hematopoiesis and lineage commitment during aging.

  9. Data show that 5'-inositol phosphatase SHIP1 deficiency extrinsically affects invariant NK (iNKT) cell proliferation.

  10. Selective deletion of Ship1 in T cells or dendritic cells impairs the formation of an adaptive TH2 response and protects animals from house dust mite-induced allergic airway inflammation.

Human Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

  1. SHIP levels and activity are lower in intestinal tissues and peripheral blood samples from patients with Crohn's disease, resulting in induction of Il1-beta (show IL1B Proteins).

  2. Underexpression of SHIP1 is associated with drug resistance in acute myeloid leukemia (show BCL11A Proteins).

  3. ectopically expressed SHIP1 accumulates in nucleolar cavities and colocalizes with the tumor suppressor protein p53 (show TP53 Proteins).

  4. Results show that expression of SHIP1 protein is targeted by miR (show MLXIP Proteins)-155 in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) suggesting it as an onco-miR (show MLXIP Proteins). The miR (show MLXIP Proteins)-155/SHIP1/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway could play an important role in the pathogenesis of AML (show RUNX1 Proteins).

  5. Overexpression of miR (show MLXIP Proteins)-155 in the gouty synovial fluid mononuclear cells leads to suppress SHIP-1 levels and enhance proinflammatory cytokines.

  6. SLAMF7 (show SLAMF7 Proteins)-triggered inhibition is mediated by a mechanism involving Src (show SRC Proteins) kinases, CD45 (show PTPRC Proteins), and SHIP-1 that is defective in MM cells

  7. The discovery and replication studies presented here show SHIP-1 to be a risk marker for acute ischemic stroke in the Chinese population, which appears to be a novel finding.

  8. High ship1 expression is associated with chronic lymphocytic leukemia.

  9. Tks5 is needed for breast carcinoma cell invadopodium precursor stabilization, where the phox homology (PX) domain of Tks5 interacts with PI(3,4)P2. SHIP2 (show INPPL1 Proteins) arrival at the invadopodium precursor coincides with the onset of PI(3,4)P2 accumulation.

  10. Based on these observations, authors conclude that miR (show MLXIP Proteins)-155 modulates the neuroinflammatory response during Japanese encephalitis virus infection via negative regulation of SHIP1 expression.

Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Protein Profile

Protein Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with INPP5D

  • inositol polyphosphate-5-phosphatase, 145kDa (INPP5D)
  • inositol polyphosphate-5-phosphatase, 145kDa (inpp5d)
  • inositol polyphosphate 5-phosphatase (EHI_159880)
  • inositol polyphosphate 5-phosphatase (EHI_153490)
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (inpp5d)
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (ship1)
  • inositol polyphosphate-5-phosphatase D (Inpp5d)
  • 13.t00027 protein
  • 256.t00004 protein
  • AI323613 protein
  • hp51CN protein
  • INPP5D protein
  • s-SHIP protein
  • SHIP protein
  • SHIP-1 protein
  • SHIP1 protein
  • SIP-145 protein

Protein level used designations for INPP5D

inositol polyphosphate-5-phosphatase, 145kDa , SH2 containing inositol phosphatase , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like , SH2 domain-containing inositol 5'-phosphatase 1 , SH2 domain-containing inositol phosphatase 1 , SH2 domain-containing inositol-5'-phosphatase 1 , SHIP-1 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 , Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , SH2 containing inositol phosphotase , SH2-containing inositol phosphatase SHIP , SIP-145 , Src homology 2 domain-containing inositol-5-phosphatase , inositol polyphosphate-5-phosphatase of 145 kDa , inositol polyphosphate-5-phosphatase, 145 kDa , p150Ship , Inositol polyphosphate-5-phosphatase 145 kDa , Inositol polyphosphate-5-phosphatase, 145 kDa , signaling inositol polyphosphate 5 phosphatase SIP-145

424745 Gallus gallus
470683 Pan troglodytes
507329 Bos taurus
100021361 Monodelphis domestica
100400043 Callithrix jacchus
100446045 Pongo abelii
100464150 Ailuropoda melanoleuca
559103 Danio rerio
3404260 Entamoeba histolytica HM-1:IMSS
3410671 Entamoeba histolytica HM-1:IMSS
100064896 Equus caballus
100526019 Sus scrofa
100561031 Anolis carolinensis
399051 Xenopus laevis
100380693 Salmo salar
16331 Mus musculus
54259 Rattus norvegicus
3635 Homo sapiens
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