INPP5D Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2723485

Product Details

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 2

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This INPP5D protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human INPP5D (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Alternative Name: Inpp5d (INPP5D Products)

Synonyms: INPP5D Protein, 256.t00004 Protein, 13.t00027 Protein, ship Protein, ship1 Protein, AI323613 Protein, SHIP Protein, SHIP-1 Protein, SHIP1 Protein, s-SHIP Protein, SIP-145 Protein, hp51CN Protein, inositol polyphosphate-5-phosphatase D Protein, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Protein, inositol polyphosphate 5-phosphatase Protein, inositol polyphosphate-5-phosphatase D L homeolog Protein, INPP5D Protein, LOC100446045 Protein, inpp5d Protein, EHI_159880 Protein, EHI_153490 Protein, inpp5d.L Protein, LOC100380693 Protein, Inpp5d Protein

Background: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

Molecular Weight: 133 kDa

NCBI Accession: NP_005532

Pathways: TCR Signaling, BCR Signaling, Warburg Effect