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Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. Additionally we are shipping Insulinoma-Associated 1 Antibodies (14) and Insulinoma-Associated 1 Proteins (3) and many more products for this protein.
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results reveal that IA1 constitutes a novel player downstream of Xash1 (show ASCL1 ELISA Kits) in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons
Insulinoma-Associated Protein 1 is a crucial regulator of neuroendocrine differentiation in lung cancer.
INSM1 autoantibodies were associated with risk of developing type 1 diabetes.
INSM1 expression was significantly increased in Neuroendocrine neoplastic vs nonneoplastic tissue.
Both the AR42J cell line and the primary cultured mouse acinar cells support role for INSM1 in pancreatic acinar cell trans-differentiation model.
The results suggest that INSM1 up-regulation plays a positive role in HSV-1 replication, probably by binding to the ICP0 promoter.
The INSM1 promoter can direct herpes simplex virus thymidine kinase (show TK1 ELISA Kits) gene expression in a nude mouse model of neuroendocrine cancer and effectively repress tumor growth in response to ganciclovir treatment.
Data show that the consistent functional effect of INSM1, either with or without other ITFs, promotes pancreatic duct cell differentiation as well as induces Panc-1 cell cycle arrest.
IA-1 gene was shown to be developmentally regulated in fetal pancreatic cells, and its expression pattern is consistent with parallel changes in islet-specific transcription factors during the endocrine differentiation of AR42J cells.
IA-1 gene is developmentally expressed in the nervous system and the NeuroD1 (show NEUROD1 ELISA Kits)/E47 (show TCF3 ELISA Kits) transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter
results presented in this study define INSM1 as a transcriptional repressor of the neuroD (show NEUROD1 ELISA Kits)/b2 gene. The molecular mechanism of INSM1 transcriptional repression is attributed to the recruitment of cyclin D1 (show CCND1 ELISA Kits) and HDAC-1 (show HDAC1 ELISA Kits) and -3
Insm1-dependent Hes1 repression is required for neuroendocrine development.
INSM1 interacts with RACK1 (show GNB2L1 ELISA Kits) protein and facilitates insulin receptor (show INSR ELISA Kits) -mediated signaling.
Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 (show NEUROG3 ELISA Kits) and Ripply3 (show DSCR6 ELISA Kits)
Data suggest that IA-2 and IA-2beta play important roles in regulation of circadian rhythm, likely through neurochemical communication among neurons of suprachiasmatic nucleus. [Insm2-beta; IA-2beta; insulinoma-associated protein 2-beta]
Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo.
This study suggested that Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic.
isolation, characterization, and identification of an interacting protein, Cbl (show CBL ELISA Kits)-associated protein (CAP)
Pancreatic and intestinal endocrine cells express Insm1 and require Insm1 for their development.
The fetal lethality of Insm1 mutant mice is caused by catecholamine deficiency, which highlights the importance of Insm1 in the development of the sympatho-adrenal lineage.
characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.
, insuloma-associated 1
, insulinoma-associated protein 1
, zinc finger protein IA-1
, insulinoma-associated protein (IA-1)
, insulinoma-associated 1-like protein b