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Integrin alpha-L Proteins (ITGAL)

ITGAL encodes the integrin alpha L chain. Additionally we are shipping ITGAL Antibodies (811) and ITGAL Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ITGAL 16408  
ITGAL 3683 P20701
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Top ITGAL Proteins at

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days

ITGAL Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , ,
, , ,
Rat (Rattus)

Top referenced ITGAL Proteins

  1. Human ITGAL Protein expressed in Human - ABIN2713386 : De Franceschi, Peuhu, Parsons, Rissanen, Vattulainen, Salmi, Ivaska, Pouwels: Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. in PLoS ONE 2015 (PubMed)

More Proteins for Integrin alpha-L (ITGAL) Interaction Partners

Mouse (Murine) Integrin alpha-L (ITGAL) interaction partners

  1. Data show that the marker antigen CD11A- fraction of hematopoietic stem cells (HSCs) contains all functional HSC (show FUT1 Proteins) activity, with the CD11A+ fraction composed of more differentiated cells that lack long-term self-renewal activity.

  2. competitive bone marrow-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells

  3. Through the use of interval-specific SNP haplotype analysis, we further refined the Civq1 locus and identified integrin alpha L (Itgal) as one of the causative genes for Civq1

  4. CD11a plays a crucial role in adipose tissue inflammation by participating in T-cell infiltration and activation.

  5. CD11a and CD11b (show ITGAM Proteins) mediate leukocyte adhesion in both arterioles and venules as well as trapping in capillaries in the lung.

  6. LFA-1/ICAM-1 (show ICAM1 Proteins)-dependent interactions between T cells and dendritic cells play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes.

  7. Data indicate that the dimerization of integrin alphaL and beta2 is highly dependent on gp96 (show HSP90B1 Proteins).

  8. LFA-1-mediated firm adhesion under conditions of shear flow requires downstream integrin signaling, which is dependent on calcium/calmodulin and the actin cytoskeleton.

  9. Taken together, these findings demonstrated that CD11a expression contributes to expansion and differentiation of primary CD8 (show CD8A Proteins) T cells but may be dispensable for secondary responses to Listeria monocytogenes infection.

  10. However, this process was pertussis toxin sensitive and dependent on the integrin LFA-1.

Human Integrin alpha-L (ITGAL) interaction partners

  1. Suggest possible role for lymphocyte CD11a in the pathogenesis immune thrombocytopenia.

  2. Data show that interleukin-18 (show IL18 Proteins) was involved in the eosinophil-mediated death of colon carcinoma cells via upregulation of CD11a/CD18 (show ITGB2 Proteins) and ICAM-1 (show ICAM1 Proteins) adhesion molecules.

  3. shear-induced CD11 (show CD1D Proteins)/CD18 (show ITGB2 Proteins) cleavage is phenotypic of neutrophilic cells, including those derived from HL60 cells

  4. Data show that leucocyte function-associated antigen-1 (integrin alphaLbeta2), DNAX accessory molecule-1 (DNAM-1 (show CD226 Proteins)) or tumour necrosis factor (show TNF Proteins)-related apoptosis-inducing ligand (TRAIL) enhance osteoclast survival when co-cultured with activated NK cells.

  5. LFA-1 function is regulated through conformational changes that include the modulation of ligand binding affinity and molecular extension.

  6. the blocking of LFA-1/ICAM-1 (show ICAM1 Proteins) interaction resulted in a significant increase in the percentage of IL-17 (show IL17A Proteins)(+) T cells expanded in nonclassical monocyte/T-cell cocultures

  7. Studied signaling mechanisms of Lymphocyte function-associated antigen-1 (LFA-1) using NMR analysis of the dynamics of the LFA-1 I-domain.

  8. CD11a, CD11c (show ITGAX Proteins), and CD18 (show ITGB2 Proteins) gene polymorphisms and susceptibility to Behcet's disease in Koreans.

  9. PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration.

  10. ITGAL is overexpressed in systemic lupus erythematosus CD4 (show CD4 Proteins)+ T cells, but expression is not linked to the typical clinical and serological parameters associated with the disease.

ITGAL Protein Profile

Protein Summary

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Integrin alpha-L Proteins (ITGAL)

  • integrin alpha L (Itgal)
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL)
  • (p180) protein
  • CD11a protein
  • LFA-1 protein
  • LFA-1A protein
  • LFA1A protein
  • Ly-15 protein
  • Ly-21 protein

Protein level used designations for Integrin alpha-L Proteins (ITGAL)

CD11 antigen-like family member A , alpha L integrin , integrin alpha-L , leukocyte adhesion glycoprotein LFA-1 alpha chain , leukocyte function-associated molecule 1 alpha chain , lymphocyte antigen 15 , lymphocyte function associated antigen 1, alpha polypeptide , LFA-1 alpha , LFA-1A , antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide , integrin gene promoter , lymphocyte function-associated antigen 1 , integrin LFA1 , lymphocyte function-associated antigen 1, alpha polypeptide , antigen CD11A , lymphocyte function-associated antigen 1, alpha

16408 Mus musculus
3683 Homo sapiens
641296 Ovis aries
281874 Bos taurus
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