ITGAL Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all ITGAL Proteins
- ITGAL (Integrin alpha-L (ITGAL))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ITGAL protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human CD11a / ITGAL (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product ITGAL Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling." in: PLoS ONE, Vol. 10, Issue 11, pp. e0143423, (2015) (PubMed).
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Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling." in: PLoS ONE, Vol. 10, Issue 11, pp. e0143423, (2015) (PubMed).
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- Target
- ITGAL (Integrin alpha-L (ITGAL))
- Alternative Name
- Cd11a,itgal (ITGAL Products)
- Synonyms
- CD11A Protein, LFA-1 Protein, LFA1A Protein, (p180) Protein, Cd11a Protein, LFA-1A Protein, Ly-15 Protein, Ly-21 Protein, CD11a Protein, ITGAL Protein, integrin subunit alpha L Protein, integrin alpha L Protein, ITGAL Protein, Itgal Protein
- Background
- ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 126.1 kDa
- NCBI Accession
- NP_002200
- Pathways
- Activated T Cell Proliferation, Integrin Complex
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