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Interferon lambda 2 Proteins (IFNL2)

Cytokine with immunomodulatory activity.

list all proteins Gene Name GeneID UniProt
IFNL2 282616 Q8IZJ0
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Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$630.00
Details

IFNL2 Proteins by Origin and Source

Origin Expressed in
Human

More Proteins for Interferon lambda 2 (IFNL2) Interaction Partners

Human Interferon lambda 2 (IFNL2) interaction partners

  1. NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1 (show IFNA1 Proteins), IFN-beta (show IFNB1 Proteins), IFN-lambda1 and IFN-lambda2 (show IL28A Proteins) through inhibition of STAT1 (show STAT1 Proteins) phosphorylation.

  2. Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29 (show IL29 Proteins)), IFN-lambda2 (IL28A (show IL28A Proteins)), IFN-lambda3 (IL-28B (show IL28B Proteins)) and IFN-lambda4.

  3. Results showed no association between genotypes and alleles of IL28A (show IL28A Proteins), IL28B (show IL28B Proteins) or IL29 (show IL29 Proteins) polymorphisms and Hepatitis C virus infection.

  4. this study provides evidence for potential IL-28A (show IL28A Proteins) participation in Behcet's diseaseand its value as a therapeutic agent.

  5. Interferon (show IFNA Proteins) regulatory factor (IRF)-3 (show IRF3 Proteins) and -7 are the key transcriptional factors for the induction of IL-28A (show IL28A Proteins) and IL-28B (show IL28B Proteins) genes, whereas NF-kappaB (show NFKB1 Proteins) is an additional requirement for the induction of the IL-29 (show IL29 Proteins) gene.

  6. The results show that IL-28A (show IL28A Proteins)/IL-28AR1 dyad-induced wound healing migration requires NF-kappaB (show NFKB1 Proteins)-mediated MMP-9 (show MMP9 Proteins) expression by MAPK (show MAPK1 Proteins) activation.

  7. IL-28 genotype was not associated with response to interferon (show IFNA Proteins) treatment (OR for GT/GG vs. TT, 0.881 (95%CI 0.388 - 2.002); P = 0.762; OR for CT/CC vs. TT, 0.902 (95%CI 0.458 - 1.778); P = 0.766).

  8. p38 MAPK (show MAPK14 Proteins) pathway mediates IL-28A (show IL28A Proteins)-induced cell migration through MMP-9 (show MMP9 Proteins) expression by activating NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins) binding motifs.

  9. Elevated expression of inflammatory cytokines (IL-5 (show IL5 Proteins), IL-20 (show IL20 Proteins), and IL-28A (show IL28A Proteins)) is associated with bladder cancer development.

  10. Plasmacytoid dendritic cells are major producers of IFN-lambda2 (show IL28A Proteins) (a type III interferon (show IFNA Proteins)) in response to viral stimulation.

Interferon lambda 2 (IFNL2) Protein Profile

Protein Summary

Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Gene names and symbols associated with Interferon lambda 2 Proteins (IFNL2)

  • interferon, lambda 2 (IFNL2)
  • IL-28A protein
  • IL28A protein

Protein level used designations for Interferon lambda 2 Proteins (IFNL2)

IFN-lambda-2 , cytokine Zcyto20 , interferon lambda 2 , interferon lambda-2 , interferon-lambda 2 , interleukin 28A (interferon, lambda 2) , interleukin-28A

GENE ID SPECIES
282616 Homo sapiens
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