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The protein encoded by IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. Additionally we are shipping IL-10 Kits (286) and IL-10 Proteins (186) and many more products for this protein.
Showing 10 out of 707 products:
Human Monoclonal IL-10 Primary Antibody for ELISA (Capture), FACS - ABIN967464
Just, Abrams, Louie, Urbano, Wara, Nicholas, Stein, King: Influence of host genotype on progression to acquired immunodeficiency syndrome among children infected with human immunodeficiency virus type 1. in The Journal of pediatrics 1995
Show all 8 references for ABIN967464
Cow (Bovine) Polyclonal IL-10 Primary Antibody for IHC, ELISA - ABIN1582204
Shi, Diez-Freire, Jun, Qi, Katovich, Li, Sriramula, Francis, Sumners, Raizada: Brain microglial cytokines in neurogenic hypertension. in Hypertension 2010
Show all 7 references for ABIN1582204
Human Monoclonal IL-10 Primary Antibody for ELISA, IHC - ABIN4324436
Sahoo, Dey, Maiti: pSiM24 is a novel versatile gene expression vector for transient assays as well as stable expression of foreign genes in plants. in PLoS ONE 2014
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Human Polyclonal IL-10 Primary Antibody for IF (p), IHC (p) - ABIN672051
Kou, Hu, Yao, Wang, Shen, Kang, Hong: Transforming growth factor-?1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment. in Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013
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Human Monoclonal IL-10 Primary Antibody for FACS - ABIN4896009
Schilling, Harasymczuk, Schuler, Egan, Whiteside: IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model. in Journal of molecular medicine (Berlin, Germany) 2012
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Human Polyclonal IL-10 Primary Antibody for EIA, Func - ABIN116099
Roca, Di Paolo, Petruzzelli, Grandaliano, Ranieri, Schena, Gesualdo: Dexamethasone modulates interleukin-12 production by inducing monocyte chemoattractant protein-1 in human dendritic cells. in Immunology and cell biology 2007
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Human Polyclonal IL-10 Primary Antibody for EIA, FACS - ABIN952917
Trajkov, Trajchevska, Arsov, Petlichkovski, Strezova, Efinska-Mladenovska, Sandevski, Spiroski: Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians. in The Indian journal of tuberculosis 2010
Show all 2 references for ABIN952917
Mouse (Murine) Monoclonal IL-10 Primary Antibody for FACS - ABIN118665
Abrams, Roncarolo, Yssel, Andersson, Gleich, Silver: Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. in Immunological reviews 1992
Human Monoclonal IL-10 Primary Antibody for ELISA, WB - ABIN1724633
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
Human Monoclonal IL-10 Primary Antibody for ELISA, WB - ABIN151606
Rho, Lampe: High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays. in Journal of proteome research 2013
TNF-alpha (show TNF Antibodies) suppresses IL-10 in peripheral B cells via up-regulating Bcl2L12 (show BCL2L12 Antibodies) in patients with ulcerative colitis.
this study shows that IL-10 gene polymorphism is associated with psoriasis in India
association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples. AA genotype of IL-10 -1082G/A significantly increased the susceptibility to diabetic nephropathy. IL-10 -819T/C and -592A/C did not.
We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, IL-10 gene polymorphisms at positions -1082A/G and -819T/C were examined. Individuals who carried the AG+GG genotype of IL-10 -1082A/G were associated with greater risk for acute pancreatitis. no significant difference was found at polymorphism at -819T/C.
IL-10 polymorphisms do not influence tacrolimus elimination in lung transplantation patients.
Findings indicate that the CC and AC+CC genotypes of interleukin-10 (IL-10) -592A/C correlate with elevated risk of developing preeclampsia, however, the interleukin-6 (IL-6 (show IL6 Antibodies)) -572G/C, -597G/A, and -174G/C polymorphisms were not found to play a critical role in susceptibility to this disorder.
IL-10 rs1800896 significantly increases the risk of recurrent pregnancy loss, while rs1800872 is not correlated with recurrent pregnancy loss risk. No significant association is demonstrated between rs1800871 and recurrent pregnancy loss risk but this requires further investigation.
this study shows that IL-10 single nucleotide polymorphisms are associated with severity of disease and response to therapy
The study suggests that the IL-10 -819C/T genetic variation may contribute to cervical cancer risk in the Chinese population examined.
Data showed that Actinobacillus (Aggregatibacter) actinomycetemicomitans GroEL protein (show GroEL Antibodies) has an antigenic effect on human primary monocytes. Aa GroEL protein (show GroEL Antibodies) responsive CD14 (show NDUFA2 Antibodies) monocytes stimulates the expression of IL12 (show IL12A Antibodies), IL10, IFNG (show IFNG Antibodies) and TNFalpha (show TNF Antibodies) cytokines with different kinetics and expression profile.
IL-10 abrogation efficiently induces regulatory T cell (Treg) formation but dampens tumoral neuropilin-1 (Nrp-1 (show NRP1 Antibodies)) Treg signaling, which simultaneously augments Th1 (show HAND1 Antibodies) and Th17 immunity.
After Mycobacterium tuberculosis infection, TNF-alpha (show TNF Antibodies) and IL-10 levels, alveolar macrophage apoptosis, and STAT3 (show STAT3 Antibodies) and p-STAT3 (show STAT3 Antibodies) expression increased significantly on days 1, 3, and 7 (P < 0.05), with maximum values on day 3.
It has been demonstrated that beta-endorphin (show POMC Antibodies) stimulates the zymosan-induced secretion of reactive oxygen species and suppresses the spontaneous production of IL-1beta (show IL1B Antibodies) and IL-10 by murine peritoneal macrophages in vivo.
the degree of fibrosis, inflammatory cell infiltration, and the number of BM-derived myofibroblasts were significantly different between IL-10 KO BM and WT BM transplanted mice, highlighting a likely role of IL-10 in pancreatitis.
CD26 (show DPP4 Antibodies) costimulatory blockade promotes lung allograft acceptance via reduced T cell infiltration, less expression of IL-17 (show IL17A Antibodies), and increased expression of IL-10, likely to be derived from alternatively activated macrophages.
Lactobacillus curvatus WiKim38 induced significantly higher levels of IL-10 in bone marrow-derived dendritic cells.
Light-emitting diode therapy increased the levels of IL-10 in a model of chronic inflammatory hyperalgesia
NAD (+) regulates Treg conversion into Th17 cells and promotes homeostasis through IL-10
Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E (show APOE Antibodies) Deficient Mice.
Melatonin upregulates the expression of IL-10 in the spleen and reduce the severity of experimental autoimmune encephalomyelitis
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (show TLR4 Antibodies) like receptor activation.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (show SOCS3 Antibodies), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Antibodies) biased, interferon-gamma (show IFNG Antibodies) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6 (show IL6 Antibodies):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Antibodies), IL-10 and TNF-alpha (show TNF Antibodies), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
ICAM1 (show ICAM1 Antibodies) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (show JUN Antibodies) may be responsible for this upregulation.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Antibodies), IL-10, and IL-6 (show IL6 Antibodies) in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (show IFNG Antibodies)+CD4 (show CD4 Antibodies)+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (show MAPK14 Antibodies) activation.
Boar seminal plasma contained TGF- beta1 (show TGFB1 Antibodies) and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha (show TNF Antibodies) and IL-10, but not IL-6 (show IL6 Antibodies), are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP (show CRP Antibodies) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (show NTS Antibodies), which may contribute to differences in the clinical presentation of NTS (show NTS Antibodies) infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (show TNF Antibodies) cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor