IL-10 antibody (AA 101-178)

Catalog No. ABIN672051

Product Details anti-IL-10 Antibody

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Binding Specificity: AA 101-178

Reactivity: Human, Mouse, Rat, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rabbit, Rat

Predicted Reactivity: Sheep,Pig,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse IL-10

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL-10 antibody (ABIN672051)

Tsai, Chen, Li, Kuo: "NLRP7 Is Involved in the Differentiation of the Decidual Macrophages." in: International journal of molecular sciences, Vol. 20, Issue 23, (2020) (PubMed).

Corradetti, Taraballi, Corbo, Cabrera, Pandolfi, Minardi, Wang, Van Eps, Bauza, Weiner, Tasciotti: "Immune tuning scaffold for the local induction of a pro-regenerative environment." in: Scientific reports, Vol. 7, Issue 1, pp. 17030, (2019) (PubMed).

Han, Wang, Qin, Xia, Wu: "LPS alters the immuno-phenotype of glioma and glioma stem-like cells and induces in vivo antitumor immunity via TLR4." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 83, (2018) (PubMed).

Pylayeva-Gupta, Das, Handler, Hajdu, Coffre, Koralov, Bar-Sagi: "IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia." in: Cancer discovery, Vol. 6, Issue 3, pp. 247-55, (2016) (PubMed).

Arendt, Sand, Marcone, Cook: "Interleukin-10 neutralizing antibody for detection of intestinal luminal levels and as a dietary additive in Eimeria challenged broiler chicks." in: Poultry science, Vol. 95, Issue 2, pp. 430-8, (2016) (PubMed).

Kemmler, Bindl, McCook, Wagner, Gröger, Wagner, Scheuerle, Radermacher, Ignatius: "Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma." in: PLoS ONE, Vol. 10, Issue 7, pp. e0131194, (2016) (PubMed).

Luo, Ma, Guo, Huang, Yan, Xiao: "Association between postmenopausal osteoporosis and experimental periodontitis." in: BioMed research international, Vol. 2014, pp. 316134, (2014) (PubMed).

Castoldi, di Gioia, Bombardi, Maestroni, Carletti, Steckelings, Dahlöf, Unger, Zerbini, Stella: "PREVENTION OF DIABETIC NEPHROPATHY BY COMPOUND 21, SELECTIVE AGONIST OF THE ANGIOTENSIN TYPE 2 RECEPTORS, IN ZUCKER DIABETIC FATTY RATS." in: American journal of physiology. Renal physiology, pp. ajprenal.00247.2014, (2014) (PubMed).

Chen, Xu, Wang, Luo, Quan, Zhou, Yang, Zhang, Wu, Liu, Long, Zhu, Xie, Luo: "Hydrogen sulfide reduces kidney injury due to urinary-derived sepsis by inhibiting NF-κB expression, decreasing TNF-α levels and increasing IL-10 levels." in: Experimental and therapeutic medicine, Vol. 8, Issue 2, pp. 464-470, (2014) (PubMed).

Kou, Hu, Yao, Wang, Shen, Kang, Hong: "Transforming growth factor-?1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 62, Issue 3, pp. 283-9, (2013) (PubMed).

Target Details for IL-10

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Alternative Name: IL-10 (IL10 Products)

Synonyms: CSIF antibody, GVHDS antibody, IL-10 antibody, IL10A antibody, TGIF antibody, Il-10 antibody, IL10X antibody, interleukin 10 antibody, IL10 antibody, Il10 antibody

Background:

Synonyms: CSIF, Il-1, Interleukin-1, Cytokine synthesis inhibitory factor, Il1, il10

Background: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Molecular Weight: 18kDa

Gene ID: 16153

UniProt: P18893

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints