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High-affinity receptor for interleukin-15.
this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 (show IL15 Antibodies) and its receptor
Spontaneous cage activity was not different and IL-15 (show IL15 Antibodies) protein levels were lower in male and female mIl15ra(fl/fl (show FLT3LG Antibodies))/Cre(+) mice.
Despite being protected against diet induced obesity, IL-15R alpha knockout mice are hyperglycemic and insulin (show INS Antibodies)-resistant.
IL-15 (show IL15 Antibodies) directly induces pro-oxidative gene expression in primary myogenic cultures. Primary myogenic cultures require IL-15RA to respond to IL-15 (show IL15 Antibodies).
we found that aging-related functional NK cell deficiency was completely reversed by injecting soluble IL-15 (show IL15 Antibodies)/IL-15Ralpha complexes.
a greater mitochondrial density and mitochondrial DNA content was found in fast muscles from IL-15-Receptor-alpha KO mice that was not due to the presence of smaller muscle fibers.
IL-15 (show IL15 Antibodies) is produced and secreted only as a heterodimer with IL-15Ralpha.
IL-15 (show IL15 Antibodies) can signal via IL-15Ralpha, JNK (show MAPK8 Antibodies), and NF-kappaB (show NFKB1 Antibodies) to drive RANTES (show CCL5 Antibodies) production by myeloid cells.
Stage 3 thymic invariant natural killer NKT (show CTSL1 Antibodies) cells are specifically reduced in IL-15Ralpha-deficient mice, whereas the acquisition of natural killer (NK) receptors occurs at stage 3 IL15 (show IL15 Antibodies)-dependent thymic cell development.
Different levels of IL-15 (show IL15 Antibodies) trans-presentation are required for different natural killer (NK) cell developmental events to reach full maturation status
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Signal transduction seems to involve STAT3, STAT5, STAT6, JAK2 and SYK. Expression of different isoforms may alter or interfere with signal transduction.
IL-15 receptor subunit alpha
, interleukin-15 receptor subunit alpha