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K(lysine) Acetyltransferase 8 Proteins (KAT8)

KAT8 encodes a member of the MYST histone acetylase protein family. Additionally we are shipping K(lysine) Acetyltransferase 8 Antibodies (59) and K(lysine) Acetyltransferase 8 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KAT8 310194 Q5XI06
KAT8 84148 Q9H7Z6
KAT8 67773 Q9D1P2
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Top K(lysine) Acetyltransferase 8 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

KAT8 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
Mouse (Murine)

More Proteins for K(lysine) Acetyltransferase 8 (KAT8) Interaction Partners

Human K(lysine) Acetyltransferase 8 (KAT8) interaction partners

  1. MOF is highly enriched in induced pluripotent stem cells (iPSCs), and MOF expression is upregulated during the reprogramming process. The ectopic expression of MOF promotes reprogramming. MOF affects Wdr5 (show WDR5 Proteins) and endogenous Oct4 (show POU5F1 Proteins) expression.

  2. Along with the PHF20/MOF complex, G9a (show EHMT2 Proteins) links the crosstalk between ERalpha (show ESR1 Proteins) methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.

  3. Data found downregulation of hMOF in gastric cancer cells and tissues. Declined hMOF expression, but not high level of HDAC4 (show HDAC4 Proteins), may account for global histone H4K16ac suggesting that loss of hMOF expression may be involved in gastric cancer progression.

  4. EZH2 (enhancer of zeste homolog 2 (show EZH2 Proteins)) was up-regulated in human oral tongue squamous cell carcinoma tissues and its level positively correlated with level of hMOF.

  5. Mutant MOF-T392A expression abrogates DSB repair in S/G2 (show STRN3 Proteins) phase cells. MOF-T392A has delayed 53BP1 (show TP53BP1 Proteins) dissociation and decreased DNA association.

  6. Results show the expression of hMOF mRNA and protein was significantly downregulated in ovarian epithelial cancer tissues, and patients with high hMOF levels showed improved survival as compared to those with low hMOF levels.

  7. The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth by targeting the expression of SIRT6 (show SIRT6 Proteins).

  8. Functional interactions of MYST1 with androgen receptor (show AR Proteins) and NF-KB are critical for prostate cancer progression.

  9. hMOF was overexpressed in human non-small cell lung cancer and was a predictor of poor survival.

  10. low expression of hMOF was strongly correlated with tumor differentiation and survival of patients with gastric cancer. While in patients with renal cell carcinoma (show MOK Proteins), downregulation of hMOF was connected to ccRCC and tissues with T1 tumor status.

Mouse (Murine) K(lysine) Acetyltransferase 8 (KAT8) interaction partners

  1. STAT5B (show STAT5B Proteins) and MOF work as negative regulators in adipogenesis.

  2. NSL and MSL HAT complexes differentially regulate specific sets of expressed genes in mESCs and during differentiation

  3. cardiac-specific MOF overexpression protected mice from transverse aortic constriction-induced cardiac hypertrophy, with reduced radios of heart weight/body weight, decreased left ventricular wall thickness and increased fractional shortening.

  4. Mof plays a critical role in T-cell differentiation and that depletion of Mof in T cells reduces T-cell numbers and, by an undefined mechanism, induces genomic instability in B cells through bystander mechanism.

  5. Depletion of MOF in mouse embryonic stem cells causes a specific decrease in expression of a subset of X-linked genes.

  6. the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and pluripotency

  7. PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF target genes

  8. Purkinje cells (PC)-specific deletion of the mouse males absent on the first (mMof) gene (Cre(-)), which encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac) and influences ATM (show ATM Proteins) function, is critical for PC longevity.

  9. Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.

  10. Data show that loss of Mof leads to reduction of histone H4 K16 acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.

K(lysine) Acetyltransferase 8 (KAT8) Protein Profile

Protein Summary

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KAT8

  • MYST histone acetyltransferase 1 (myst1)
  • K(lysine) acetyltransferase 8 (kat8)
  • K(lysine) acetyltransferase 8 (MYST1)
  • MYST histone acetyltransferase 1 (MYST1)
  • MYST histone acetyltransferase 1 (LOC100341732)
  • K (lysine) acetyltransferase 8 (Kat8)
  • K(lysine) acetyltransferase 8 (KAT8)
  • K(lysine) acetyltransferase 8 (Kat8)
  • 2010203C02Rik protein
  • 5830450F21Rik protein
  • D7Ertd629e protein
  • hMOF protein
  • MOF protein
  • MYST1 protein
  • wu:fb22g02 protein
  • wu:fj22d09 protein
  • ZC2HC8 protein
  • zgc:66387 protein

Protein level used designations for KAT8

MYST histone acetyltransferase 1 , histone acetyltransferase KAT8 , K(lysine) acetyltransferase 8 , probable histone acetyltransferase MYST1-like , MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 , MYST protein 1 , MYST-1 , lysine acetyltransferase 8 , probable histone acetyltransferase MYST1 , histone acetyltransferase MYST1 , ortholog of Drosophila males absent on the first (MOF) , histone acetyltransferase Myst1

548988 Xenopus (Silurana) tropicalis
100003790 Danio rerio
100019305 Monodelphis domestica
100064910 Equus caballus
100341732 Oryctolagus cuniculus
100387289 Callithrix jacchus
100435717 Pongo abelii
100522367 Sus scrofa
100593658 Nomascus leucogenys
310194 Rattus norvegicus
84148 Homo sapiens
67773 Mus musculus
479777 Canis lupus familiaris
100125883 Bos taurus
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