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The protein encoded by KISS1R is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. Additionally we are shipping KISS1R Antibodies (99) and and many more products for this protein.
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duplicated kiss1r genes evolved a distinct gene expression pattern, different ligand selectivity, and novel nuclear isoforms. While a single kiss1ra mRNA was detected exclusively in the brain, 5 kiss1rb transcripts were found in many peripheral tissues.
The only site of expression of kiss1r mRNA cells was the ventromedial habenula, showing an expression pattern very similar to that of the kiss1 (show KISS1 ELISA Kits) mRNA or proKiss1 peptide.
Zebrafish kiss1r was expressed predominantly in the brain, with a minor level of expression in the eye.
Kiss1 (show KISS1 ELISA Kits)/Kiss1r system may participate in puberty initiation in fish as well.
Kisspeptin-10 may contribute to accelerate the progression and instability of atheromatous plaques, leading to plaque rupture. The GPR54 antagonist may be useful for prevention and treatment of atherosclerosis.
Metabolism and Energy Expenditure, But Not Feeding or Glucose Tolerance, Are Impaired in Young Kiss1r KO Female Mice
Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R (show TACR3 ELISA Kits)) ligands.
In hu (show KISS1 ELISA Kits)man cumulus GCs, kiss1r mRNA levels were positively correlated with age but not with BMI. There was no expression of kiss1 mRNA in either (show KISS1 ELISA Kits) cumulus or mural GCs
KISS1R signaling induces invadopodia formation and activation of key invadopodia proteins, cortactin (show CTTN ELISA Kits), cofilin (show CFL1 ELISA Kits) and membrane type I matrix metalloproteases (MT1-MMP (show MMP14 ELISA Kits)).
KISS1R Low Expression Correlates with Colorectal Liver Metastasis.
KiSS1 (show KISS1 ELISA Kits) is a metastasis suppressor gene of pancreatic cancer, and this suppression is not dependent on the expression levels of GPR54.
confirmed that mutations in KISS1 (show KISS1 ELISA Kits) and KISS1R are not a common cause for ICPP
Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10 (show PRLHR ELISA Kits), GPR54 and GPR103 (show QRFPR ELISA Kits).
Two novel heterozygous missense mutations in FGFR1 (show FGFR1 ELISA Kits) and one novel heterozygous missense mutation in KISS1R, were identified in in Chinese Kallmann Syndrome Males with Cleft Lip/Palate.
data suggest the utility of the KISS1R as a novel biomarker for multiple myeloma, capable of targeting both tumor cells and host cells of the tumor microenvironment
kiss1 (show KISS1 ELISA Kits) and kiss1r mRNA levels were significantly higher in old compared to reproductive-aged mice, and diet-induced obesity did not alter kiss1 (show KISS1 ELISA Kits) or kiss1r mRNA levels. Compared to young control mice, young MCP-1 (show CPT1B ELISA Kits) knockout mice had significantly lower ovarian kiss1 (show KISS1 ELISA Kits) mRNA
On D4 of pregnancy, the mouse uterus expresses a functional kisspeptin/KISS1R signaling system.
Gnaq (show GNAQ ELISA Kits) was selectively inactivated in GnRH (show GNRH1 ELISA Kits) neurons of global Gna11 (show GNA11 ELISA Kits)--null mice, but they still responded to kisspeptin, confirming that KISS1R signals via non-Galphaq (show GNAQ ELISA Kits)/11-coupled pathways.
orchestrated onset of kisspeptin and GPR54 expression in the male embryonic brain at embryonic day 13.5
Results demonstrate defective negative feedback in global Gpr54-null mice that cannot be attributed to a lack of prior exposure of the gonadotropin-releasing hormone neuronal network to cyclical estradiol
Expression of Kiss1 (show KISS1 ELISA Kits) and Gpr54 was confirmed in mouse placenta but no differences in birth weight were found in mice that had been supported by a mutant placenta during fetal development.
Kiss1 (show KISS1 ELISA Kits)/GPR54 system is involved in promoting uterine decidualization during early pregnancy in mice
Kiss1r in GnRH neurons is critical for reproductive development and fertility.
The KISS1R gene is mapped and mutations within the gene are determined not to be responsible for divergent age at puberty.
The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty.
G protein-coupled receptor 54
, KISS1 receptor like
, kisspeptin receptor 2
, KiSS-1 receptor
, kisspeptins receptor
, G-protein coupled receptor OT7T175
, kiSS-1 receptor
, metastin receptor
, G-protein coupled receptor 54
, orphan G protein-coupled receptor 54
, orphan G protein-coupled receptor GPR54