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anti-KRIT1, Ankyrin Repeat Containing (KRIT1) Antibodies

KRIT1 encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. Additionally we are shipping KRIT1, Ankyrin Repeat Containing Proteins (4) and KRIT1, Ankyrin Repeat Containing Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KRIT1 362317  
KRIT1 889 O00522
KRIT1 79264 Q6S5J6
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Top anti-KRIT1, Ankyrin Repeat Containing Antibodies at

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB KRIT1 Antibody (N-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the KRIT1 antibody detected the KRIT1 protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB   100 μg Log in to see 4 to 6 Days
Human Mouse Un-conjugated WB Western Blot analysis of KRIT1 expression in transfected 293T cell line by KRIT1 monoclonal antibody (M01), clone 2C7. Lane 1: KRIT1 transfected lysate(84.3 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged KRIT1 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000; TMB staining; Read the data in MicroplateReader by 450 Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti KRIT1 Polyclonal Antibody, Unconjugated (ABIN1387606) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
Human Rabbit Un-conjugated IF, WB Immunofluorescence staining of Human foreskin (Cryo-section of unfixed tissue) with anti-CCM1 Antibody Cat.-No AP26021PU-L (red, dilution: 1/50). Costaining of endothelial cells with anti-CD31 (green). Note specific staining in the wall of a subset of vessel. Nuclei counter-stained with Dapi (blue). Specimen provided by Prof. Dr. J. Wilting and Dr. K. Buttler, Goettingen. Western analysis of recombinant Human CCM-1 (FERM domain) and recombinant Human full length CCM-1 using a Rabbit polyclonal anti-Human CCM-1 antibody Cat.-No AP26021PU generated against the recombinant FERM domain of Human CCM-1. 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated EM, WB Western Blot: KRIT1 Antibody [NBP2-19307] - Sample (30 ug of whole cell lysate) A: Raji 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 6 to 9 Days
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged KRIT1 is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 9 Days
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days

KRIT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) , ,

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Human , , , ,
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Mouse (Murine) , ,

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More Antibodies against KRIT1, Ankyrin Repeat Containing Interaction Partners

Cow (Bovine) KRIT1, Ankyrin Repeat Containing (KRIT1) interaction partners

  1. These findings suggest that lysoPC induces CaM phosphorylation at Tyr (show TYR Antibodies)(99) by a Src (show SRC Antibodies) family kinase and that phosphorylated CaM activates PI3K to produce PIP3, which promotes TRPC6 (show TRPC6 Antibodies) translocation to the cell membrane.

  2. calmodulin promotes catalysis by shaping the physical and temporal conformational behaviors of NOS (show NOS Antibodies).

  3. examination of Ca(+2 (show CA2 Antibodies))-calmodulin showing highly significant correlations between surface area and side-chain contact predictions for individual side chains and the crystal structure, is reported.

  4. Fluorescence decays of fluorescently labeled CaM bound to eNOS (show NOS3 Antibodies) reveal four distinct conformational states and single-molecule fluorescence trajectories show multiple fluorescence states with transitions between states

  5. key regulatory role of CaM involves the stabilization of structural intermediates and precise positioning of the pivot for the FMN (show FMN1 Antibodies) domain tethered shuttling motion to accommodate efficient and rapid electron transfer in the homodimer of eNOS (show NOS3 Antibodies).

  6. The results provide a basic idea that could lead to the development of small peptides binding with high affinity to CaM and inhibiting Ca(2 (show CA2 Antibodies))-CaM complex formation in the future.

  7. CaM is collapsed around the adenylyl cyclase 8 (show ADCY8 Antibodies) peptides that binds to CaM in an antiparallel orientation.

  8. Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a (show MYO5A Antibodies).

  9. Data indicate that the information obtained can enhance understanding of how CaM interacts with K-RasB in physiological environments.

  10. we propose a model in which the partial unfolding of the suppressor domain by apo (show C9orf3 Antibodies)-CaM and the stepwise binding of the N lobe (show LTF Antibodies) of CaM to the suppressor domain are important elements of calcium/CaM inhibition of IP(3)R (show ITPR1 Antibodies)

Human KRIT1, Ankyrin Repeat Containing (KRIT1) interaction partners

  1. Studies suggest that the 3 proteins of the Cerebral Cavernous Malformations (CCM) complex KRIT1/CCM1, CCM2/malcavernin (show CCM2 Antibodies) and CCM3/PDCD10 (show PDCD10 Antibodies) not only require one another for reciprocal stabilization, but also act as a platform for signal transduction.

  2. Valproic acid reduces intracellular ROS (show ROS1 Antibodies) level by the modulation of KRIT1 and its correlated proteins, FoxO1 (show FOXO1 Antibodies), SOD2 (show SOD2 Antibodies), and cyclin D1 (show CCND1 Antibodies) in mesenchymal stromal cells.

  3. KRIT1 protects endothelial integrity during mechanical stress and trap6 exposure.

  4. Novel CCM1 deletion mutation segregated with cerebral cavernous angioma in a Chinese family.

  5. Case Report: cerebral cavernous malformations and unilateral moyamoya disease in a patient with a new mutation in the KRIT-1 /CCM1 gene.

  6. Here we discuss nuclear functions of adhesion complex proteins with a special focus on the CCM-1/KRIT-1 protein, which may turn out to be yet another adhesion complex protein with a second life.

  7. Data find that several disease-associated missense mutations in CCM2 (show CCM2 Antibodies) have the potential to interrupt the KRIT1-CCM2 (show CCM2 Antibodies) interaction by destabilizing the CCM2 (show CCM2 Antibodies) PTB (show PTBP1 Antibodies) domain and that a KRIT1 mutation also disrupts this interaction

  8. Genetic analysis of familial cerebral cavernous malformation in Japanese involved the KRIT1 gene.

  9. Data indicate the regulatioin of vascular endothelial growth factor (VEGF) signaling in Krev-interaction trapped 1 (KRIT1)-depleted endothelial cells.

  10. Data indicate that the major binding site for binding of sorting nexin 17 (SNX17 (show SNX17 Antibodies)) is confined to the NPXF2 motif in cytoplasmic adaptor (show TICAM2 Antibodies) protein Krev interaction trapped 1 (KRIT1).

Mouse (Murine) KRIT1, Ankyrin Repeat Containing (KRIT1) interaction partners

  1. Lesions develop in a stereotypic location and pattern, preceded by endothelial hypersprouting as confirmed in a zebrafish model of disease. The vascular defects seen with loss of Ccm1 suggest a defect in endothelial flow response.

  2. CCM1 silencing in endothelial cells caused decreased Notch3 (show NOTCH3 Antibodies) activity in cocultured pericytes

  3. Data indicate that vascular endothelial growth factor (VEGF) signaling contributes to modifying endothelial function in Krev-interaction trapped 1 (KRIT1)-deficient cells and microvessel permeability in Krit1(+/-) mice.

  4. The CCM1 loss resulted in ICAP-1 (show ITGB1BP1 Antibodies) destabilization, which increased beta1 integrin activation and led to increased RhoA (show RHOA Antibodies)-dependent contractility.

  5. Data indicate an integral role for KRIT1 in microvessel homeostasis and the vascular response to inflammation.

  6. Pdcd10 (show PDCD10 Antibodies) has a different role in cerebral cavernous malformation than Ccm2 (show CCM2 Antibodies) and Krit1

  7. Results suggests that KRIT1 limits the accumulation of intracellular oxidants and prevents oxidative stress-mediated cellular dysfunction and DNA damage by enhancing the cell capacity to scavenge intracellular ROS (show ROS1 Antibodies).

  8. The KRIT1-CCM2 (show CCM2 Antibodies) interaction regulates endothelial junctional stability and vascular barrier function by suppressing activation of the RhoA (show RHOA Antibodies)/ROCK signaling pathway.

  9. KRIT1 regulates beta-catenin (show CTNNB1 Antibodies) signaling, and Krit1(+/-) mice are more susceptible to beta-catenin (show CTNNB1 Antibodies)-driven intestinal adenomas.

  10. evidence of differential Krit1 and Rap1A (show RAP1A Antibodies) expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells.

Zebrafish KRIT1, Ankyrin Repeat Containing (KRIT1) interaction partners

  1. CCM3 (show PDCD10 Antibodies) signals through sterile 20-like kinases to regulate both endothelial and epithelial cell junctions in development and disease.

  2. endothelial cellular morphogenesis is regulated by CCM1 proteins during development and pathogenesis. [CCM1]

  3. the direct interaction between Rap1 (show TERF2IP Antibodies) and KRIT1 is required for KRIT1 function in cardiovascular development.

  4. Ccm1 has been identified as a key angiogenic modulator in microvascular tubulogenesis.

  5. Zebrafish embryos with the recessive lethal mutations santa (san) and valentine (vtn (show VTN Antibodies)) do not thicken, but do add the proper number of cells to the myocardium.

KRIT1, Ankyrin Repeat Containing (KRIT1) Antigen Profile

Protein Summary

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with KRIT1

  • KRIT1, ankyrin repeat containing (Krit1) antibody
  • KRIT1, ankyrin repeat containing (KRIT1) antibody
  • Krev interaction trapped protein 1 (krit1) antibody
  • calmodulin-like (CALM) antibody
  • KRIT1, ankyrin repeat containing (krit1) antibody
  • 2010007K12Rik antibody
  • A630036P20Rik antibody
  • AA432855 antibody
  • AI450393 antibody
  • AI643869 antibody
  • BB155247 antibody
  • BB235701 antibody
  • CALM2 antibody
  • CAM antibody
  • Ccm1 antibody
  • fb36f07 antibody
  • krit1 antibody
  • RGD1305929 antibody
  • san antibody
  • santa antibody
  • wu:fb36f07 antibody
  • zgc:63585 antibody

Protein level used designations for KRIT1

krev interaction trapped protein 1 , Krev interaction trapped protein 1 , caM , calmodulin , calmodulin 2 (phosphorylase kinase, delta) , ankyrin repeat-containing protein Krit1 , cerebral cavernous malformations 1 protein , krev interaction trapped 1 , cerebral cavernous malformations 1 protein homolog , ccm1

362317 Rattus norvegicus
420549 Gallus gallus
482299 Canis lupus familiaris
100050998 Equus caballus
100517669 Sus scrofa
100195181 Salmo salar
326597 Bos taurus
889 Homo sapiens
79264 Mus musculus
407996 Bos taurus
321836 Danio rerio
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