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KiSS-1 Metastasis-Suppressor Proteins (KISS1)

KISS1 is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. Additionally we are shipping KISS1 Antibodies (34) and KISS1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KISS1 3814 Q15726
KISS1 289023 Q7TSB7
KISS1 280287 Q6Y4S4
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Top KISS1 Proteins at

Showing 8 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
Human Un-conjugated   2 μg Log in to see 6 Days

KISS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Rat (Rattus)

Mouse (Murine)

More Proteins for KiSS-1 Metastasis-Suppressor (KISS1) Interaction Partners

Cow (Bovine) KiSS-1 Metastasis-Suppressor (KISS1) interaction partners

  1. Kisspeptin neuronal system plays an essential role as the gatekeeper of reproduction via stimulating GnRH secretion.(review)

Zebrafish KiSS-1 Metastasis-Suppressor (KISS1) interaction partners

  1. results reveal the pattern of kisspeptin neurones and their connections with GnRH3 neurones in the brain, suggesting distinct mechanisms for Kiss1 and Kiss2 in regulating reproductive events in zebrafish.

  2. These findings implicate that Kiss1 could modulate fear responses mediated by 5-HT1A and 5-HT2 receptors

  3. These findings suggest that the autocrine-regulated habenular Kiss1 neurons indirectly regulate the serotonergic system in the raphe nuclei through the habenula-interpeduncular nucleus in the zebrafish.

  4. Dada (show ADA Proteins) show that kiss1-expressing neurons are only located in the habenular nucleus, while kiss2-expressing neurons are found in the dorsal and ventral hypothalamus.

  5. The zebrafish kiss1 was expressed in brain, intestine, adipose tissue and testis.

  6. Kiss1/Kiss1r system may participate in puberty initiation in fish as well.

Human KiSS-1 Metastasis-Suppressor (KISS1) interaction partners

  1. KISS1 Low Expression Correlates with Colorectal Liver Metastasis.

  2. KiSS1 is a metastasis suppressor gene of pancreatic cancer, and this suppression is not dependent on the expression levels of GPR54.

  3. confirmed that mutations in KISS1 and KISS1R are not a common cause for ICPP

  4. KiSS-1 downregulation may play a role in tumor progression and metastasis of oral squamous cell carcinoma, and may be a reliable biomarker for predicting clinical outcome in this disease.

  5. The gene-gene interactions identified in the survival tree analysis support the importance of VEGFR2 (show KDR Proteins) rs2071559 and KISS1 rs71745629 in modulating these outcomes.

  6. These findings are of tremendous significance and will greatly shape how KISS1 will be developed as a therapeutic agent in augmenting the reproductive potential of both women and important livestock species--{REVIEW}

  7. On D4 of pregnancy, the Kiss 1 null uterus expresses functional KISS1R molecules.

  8. Metastin levels were higher in women with polycystic ovary syndrome as compared to controls regardless of BMI.

  9. Metastin expression is induced in ESCs (show NR2E3 Proteins) through decidualization.

  10. Present data do not confirm the protective role of KiSS1/KiSS1R in breast cancer progression, but our results do support the hypothesis that KiSS1/KiSS1R system is activated even in primary breast cancer and sustained during invasion to local lymph nodes.

Mouse (Murine) KiSS-1 Metastasis-Suppressor (KISS1) interaction partners

  1. Data show that estradiol has no effect on kisspeptin (Kiss1) mRNA expression in prepubertal Kiss1 cell-specific estrogen receptoralpha knockout (KERalphaKO) mice.

  2. On D4 of pregnancy, the mouse uterus expresses a functional kisspeptin/KISS1R signaling system.

  3. The results suggest that the 5'-upstream region of Kiss1 locus functions as an enhancer for the arcuate nucleus Kiss1 gene expression in mice.

  4. Gnaq (show GNAQ Proteins) was selectively inactivated in GnRH (show GNRH1 Proteins) neurons of global Gna11 (show GNA11 Proteins)--null mice, but they still responded to kisspeptin, confirming that KISS1R signals via non-Galphaq (show GNAQ Proteins)/11-coupled pathways.

  5. neural circuits between kisspeptin and GnRH neurons in the male mouse arcuate nucleus of the hypothalamus established before birth

  6. the mechanism by which kisspeptin is suppressed during lactation involves a number of factors, including chronically elevated levels of prolactin (show PRL Proteins)

  7. findings suggest that the suppressive signalling of RFRP-3 on Gonadotrophin releasing hormone transcription may dominate over kisspeptin induction in the mHypoA-GnRH/GFP Gonadotrophin releasing hormone neuronal cell model.

  8. Results demonstrate defective negative feedback in global Gpr54-null mice that cannot be attributed to a lack of prior exposure of the gonadotropin-releasing hormone neuronal network to cyclical estradiol

  9. Expression of Kiss1 and Gpr54 was confirmed in mouse placenta but no differences in birth weight were found in mice that had been supported by a mutant placenta during fetal development.

  10. This study show that estrogen is found to permit circadian AVP (show AVP Proteins) signaling at preoptic kisspeptin neurons rather than dynamically modulate its activity throughout the estrous cycle.

KISS1 Protein Profile

Protein Summary

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.

Gene names and symbols associated with KISS1

  • KiSS-1 metastasis-suppressor (KISS1)
  • KiSS-1 metastasis-suppressor (kiss1)
  • KiSS-1 metastasis-suppressor (Kiss1)
  • KISS1 receptor (Kiss1r)
  • Eseptin protein
  • Gpr54 protein
  • HH13 protein
  • KiSS-1 protein
  • metastatin protein

Protein level used designations for KISS1

Kiss1 metastasis-suppressor , kisspeptin 1 , kisspeptin-1 , malignant melanoma metastasis-suppressor , metastasis-suppressor KiSS-1 , metastin , prepro-kisspeptin , Kiss1 variant E1a-E2b-E3 , Kiss1 variant E1b-E2a-E3 , Kiss1 variant E1b-E2b-E3 , MLL septin-like fusion , 0610012C01Rik , G protein-coupled receptor 54 , G-protein coupled receptor 54 , G-protein coupled receptor OT7T175 , kiSS-1 receptor , kiSS-1R , kisspeptins receptor , mOT7T175 , metastin receptor , orphan G protein-coupled receptor 54

615613 Bos taurus
100134982 Danio rerio
3814 Homo sapiens
289023 Rattus norvegicus
280287 Mus musculus
114229 Mus musculus
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