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Lymphotoxin-alpha Proteins (LTA)

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. Additionally we are shipping LTA Antibodies (219) and LTA Kits (75) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LTA 16992 P09225
LTA 4049 P01374
LTA 25008 Q06332
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Top LTA Proteins at

Showing 10 out of 70 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Chemical Un-conjugated Human TNF-beta on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized  Human TNF-beta (Cat# TNB-H5214) at 5 μg/mL (100 µl/well), can bind Human TNFR2, His Tag (Cat# TN2-H5227) with a linear range of 2-62 ng/mL. 50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Chemical Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Chemical His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Wild boar His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rabbit His tag,T7 tag 100 μg Log in to see 11 to 13 Days

LTA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Top referenced LTA Proteins

  1. Chemical LTA Protein expressed in Escherichia coli (E. coli) - ABIN2002479 : Williams-Abbott, Walter, Cheung, Goh, Porter, Ware: The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand. in The Journal of biological chemistry 1997 (PubMed)
    Show all 4 references for ABIN2002479

  2. Human LTA Protein expressed in Escherichia coli (E. coli) - ABIN667775 : Messer, Spengler, Jung, Honold, Blömer, Pape, Riethmüller, Weiss et al.: Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced ... in The Journal of experimental medicine 1991 (PubMed)
    Show all 2 references for ABIN667775

  3. Chemical LTA Protein expressed in HEK-293 Cells - ABIN2181836 : Gray, Aggarwal, Benton, Bringman, Henzel, Jarrett, Leung, Moffat, Ng, Svedersky: Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. in Nature 1985 (PubMed)
    Show all 2 references for ABIN2181836

  4. Human LTA Protein expressed in Escherichia coli (E. coli) - ABIN1305059 : Paul, Ruddle: Lymphotoxin. in Annual review of immunology 1988 (PubMed)

More Proteins for Lymphotoxin-alpha (LTA) Interaction Partners

Mouse (Murine) Lymphotoxin-alpha (LTA) interaction partners

  1. Expression of LT alpha and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP (show AIP Proteins) associated secondary extra pancreatic pathologies.

  2. These data demonstrate that lymphotoxin (show LTB Proteins)-expressing cells, such as Th1 (show HAND1 Proteins) cells, mediate stromal keratitis.

  3. TNFalpha (show TNF Proteins) and LTalpha mediate post-myocardial infarction cardiac dysfunction via TNFR1 (show TNFRSF1A Proteins) stimulation, whereas TNFR2 (show TNFRSF1B Proteins) activation is cardioprotective against ischemic injury.

  4. findings show that soluble lymphotoxin alpha (sLTalpha3) produced by RORgammat(+) innate lymphoid cells controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut (show GUSB Proteins)

  5. Data suggest that among many cytokines increased after myocardial ischemia/reperfusion (MI/R), lymphotoxin-alpha (Lta) is the only cytokine remaining elevated 24-72 h after reperfusion; LTa appears to suppress adiponectin expression following MI/R.

  6. study reports that mice deficient in lymphotoxin (show LTB Proteins), a key molecule in gut (show GUSB Proteins) immunity, were resistant to diet-induced obesity

  7. Data from lymphotoxin-alpha knockout mice suggest that lymphotoxin-alpha contributes to diet-induced weight gain and adiposity (leading to obesity) and is required to modulate accumulation of immune cells in adipose tissue (as in obesity).

  8. Grafts deficient in lymphotoxin-alpha have an attenuated capacity to induce graft-versus-host disease.

  9. Our findings suggest a contribution of lymphotoxin alpha in the control of chronic M. tuberculosis infection.

  10. The organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin alpha; however, the organization and recruitment of lymphocytes within NALT are dependent on LT alpha.

Human Lymphotoxin-alpha (LTA) interaction partners

  1. After multivariable analysis TNF-alpha (show TNF Proteins) polymorphism showed no consistent association with leukemia. CONCLUSIONS: This meta-analysis suggests that the LT-alpha +252 AA polymorphism is associated with the risk of leukemia

  2. Tumor Necrosis Factor (show TNF Proteins) and Lymphotoxin (show LTB Proteins) in Regulation of Intestinal Inflammation.

  3. joint effects of these CRP, TNF-alpha, and LTA risk alleles with physical inactivity in elders were observed, suggesting that physical activity may modulate effects of genotypes on handgrip strength.

  4. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes

  5. Polymorphism +252 LT gene did not show any significant association with COPD (show ARCN1 Proteins).

  6. TNFB+252G/A was associated with presence of immune thrombocytopenia.

  7. LTA polymorphism is associated with genetic susceptibility of systemic lupus in Asians, but not in rheumatoid arthritis.

  8. Studied the association between immuno-modulatory gene polymorphisms (including LTA) and risk for nasal NK/T-cell lymphoma in a Chinese population. Found The LTA +252 GA + AA genotypes were associated with increased risk for NK/T-cell lymphoma.

  9. TNF-beta NcoI polymorphism, by itself, was not associated with increased stroke susceptibility. But the homozygous genotype for the allele TNFB2 was associated with higher expression of classical inflammatory and metabolic markers of stroke.

  10. These results support an association between ANKK1 and LTA genetic markers and vulnerability to schizophrenia and show the potential influence of just one copy of the mutant C or G allele in the Egyptian population.

LTA Protein Profile

Protein Summary

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with Lymphotoxin-alpha Proteins (LTA)

  • lymphotoxin A (Lta)
  • lymphotoxin alpha (LTA)
  • lymphotoxin alpha (Lta)
  • lymphotoxin alpha (TNF superfamily, member 1) (LTA)
  • hlb382 protein
  • LT protein
  • LT-alpha protein
  • LT-[a] protein
  • LTalpha protein
  • Ltx protein
  • LT[a] protein
  • TNF-beta protein
  • TNFB protein
  • TNFSF1 protein
  • Tnfsf1b protein

Protein level used designations for Lymphotoxin-alpha Proteins (LTA)

TNF beta , lymphotoxin alpha , lymphotoxin-alpha , tumor necrosis factor ligand superfamily member 1 , LT-alpha , TNF superfamily, member 1 , TNF-beta , tumor necrosis factor beta , lymphotoxin A , lymphotoxin alpha (TNF superfamily, member 1) , Lymphotoxin-alpha , tumour necrosis factor beta , ATP-binding cassette, sub-family F (GCN20), member 1

16992 Mus musculus
4049 Homo sapiens
25008 Rattus norvegicus
607183 Canis lupus familiaris
280845 Bos taurus
407742 Sus scrofa
100328931 Oryctolagus cuniculus
101123078 Ovis aries
494185 Pan troglodytes
715425 Macaca mulatta
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