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The integral membrane protein encoded by LPAR1 is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. Additionally we are shipping LPAR1 Kits (8) and LPAR1 Proteins (4) and many more products for this protein.
Showing 10 out of 54 products:
Human Polyclonal LPAR1 Primary Antibody for EIA, WB - ABIN358617
Boucharaba, Serre, Guglielmi, Bordet, Clézardin, Peyruchaud: The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases. in Proceedings of the National Academy of Sciences of the United States of America 2006
These results suggest that autotaxin-LPA-LPA receptor 1-AKT1 signaling axis is critical for maintaining Cancer stem cells(CSC) characteristics through an autocrine loop and provide a novel therapeutic target for ovarian CSCs
LPA (show APOA Antibodies)-type agonist, via Carbonyl-oxygen/Lys39 interaction facilitates the formation of a hypothetical N-terminal cap tightly packed over the LPA1 heptahelical bundle.
Data show high expression levels of LPAR2 (show LPAR2 Antibodies) and LPAR1 in endometrial cancer tissue with positive correlations with FIGO stage suggesting them as potential biomarkers for endometrial cancer progression.
Data suggest LPA (lysophosphatidic acid; acting via LPAR1) and endothelin activate Cdc42, concurrent with biphasic decrease in Rac1 activity, differential effects on RhoA; LPA/endothelin stim. leads to remodeling of invadosomes in melanoma cells.
we show that LPAR1 is a novel susceptibility gene for human essential hypertension and that stress, such as shortage of sleep, increases the susceptibility of patients with risk allele to essential hypertension.
Study presents three crystal structures of LPA1 in complex with antagonist tool compounds selected and designed through structural and stability analyses.
Results indicate that lysophosphatidic acid-lysophosphatidic acid receptor 1 (LPA (show APOA Antibodies)-LPA1) signaling contributes to the activation of rheumatoid arthritis fibroblast-like synoviocytes (FLSs).
HB-EGF (show HBEGF Antibodies) is a biomarker for LPA1 receptor activation in human breast and prostate cancers.
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 (show CD97 Antibodies) in a breast cancer cell line.
LPA1 and LPA2 (show LPAR2 Antibodies) are major LPA (show APOA Antibodies) receptor subtypes compared with low-expressed LPA3 (show LPAR3 Antibodies) in PANC-1 tumor cells.
Data show that lysophosphatidic acid receptor 1 (LPA1)-green fluorescent proteins can be used to directly quantify the running-induced increase in precursor proliferation.
Results suggest a relevant role for the Lysophosphatidic acid/Lysophosphatidic acid receptor 1 signaling system in alcoholism. In addition, the LPA1-null mice emerge as a new model for genetic vulnerability to excessive alcohol drinking
Data show that lysophosphatidic acid (LPA) induces phosphorylation of trkA (show NTRK1 Antibodies) receptor (TrkA (show NTRK1 Antibodies)) through lysophosphatidic acid receptor 1 (LPA1) binding to TrkA (show NTRK1 Antibodies)
LPA receptor has a role in bone loss in ovariectomized mice, but the favorable effect of its inhibition on bone remodeling is less general than hypothesized
These findings suggest that tumor and stromal LPA receptors, in particular LPA1 and LPA5 (show LPAR5 Antibodies), play different roles in invasion and the seeding of metastasis
LPA1 receptor is involved in emotional behaviors and in the anatomical integrity of the corticolimbic circuit, the deregulation of which may be a susceptibility factor for anxiety disorders.
These results suggest that Ile325, Tyr85, and Leu87 within LPA1 are essential for LPA1 protein properly folding in the ER.
These results suggest that LPA1 receptor-mediated amplification of spinal LPA production is required for the development of paclitaxel-induced neuropathic pain.
these results demonstrate that LPA1 is essential for in vitro and in vivo osteoclast activities.
Ultrastructural analyses of peripheral nerves in mouse null-mutants for LPA1 showed delayed schwann cell-to-axon segregation, polyaxonal myelination by single schwann cells, and thinner myelin sheaths.
Lysophosphatidic acid stimulates PGE (show LIPF Antibodies)(2) production, cell viability, and intracellular calcium ion mobilization in cultured stromal endometrial cells via Ki16425-sensitive LPA1 receptors.
the ATX-LPA-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates
LPA(1) is necessary for lymphatic vessel formation during embryonic development in zebrafish.
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
, lysophosphatidic acid receptor 1
, lysophosphatidic acid receptor 1-like
, LPA receptor 1
, lysophosphatidic acid receptor Edg-2
, ventricular zone gene 1
, G-protein coupled receptor 26
, clone 4.9
, endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2
, endothelium differentiation gene 2