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LPAR1 antibody (AA 316-364) (Biotin)

LPAR1 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7158745
  • Target See all LPAR1 Antibodies
    LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))
    Binding Specificity
    • 15
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 316-364
    Reactivity
    • 43
    • 22
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 44
    • 2
    Rabbit
    Clonality
    • 41
    • 5
    Polyclonal
    Conjugate
    • 22
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LPAR1 antibody is conjugated to Biotin
    Application
    • 36
    • 17
    • 13
    • 11
    • 9
    • 7
    • 2
    • 2
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Lysophosphatidic acid receptor 1 protein (316-364AA)
    Isotype
    IgG
    Top Product
    Discover our top product LPAR1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))
    Alternative Name
    LPAR1 (LPAR1 Products)
    Synonyms
    EDG2 antibody, GPR26 antibody, Gpcr26 antibody, LPA1 antibody, Mrec1.3 antibody, VZG1 antibody, edg-2 antibody, rec.1.3 antibody, vzg-1 antibody, Edg2 antibody, EDG-2 antibody, 5031439C20 antibody, AI326300 antibody, Kdt2 antibody, lpA1 antibody, edg2 antibody, si:dz22b13.1 antibody, si:dz46m7.1 antibody, zgc:92157 antibody, LPA receptor 1-A antibody, LPA-1-A antibody, gpr26 antibody, lpa1 antibody, lpa1r antibody, lpa1r1 antibody, lpar1 antibody, lpar1-a antibody, lpar1-b antibody, vzg1 antibody, xLPA1-1 antibody, LPA receptor 1-B antibody, LPA-1-B antibody, edg2-A antibody, xLPA1-2 antibody, xlpa1R antibody, lysophosphatidic acid receptor 1 antibody, lysophosphatidic acid receptor 1 S homeolog antibody, lysophosphatidic acid receptor 1 L homeolog antibody, LPAR1 antibody, Lpar1 antibody, lpar1 antibody, lpar1.S antibody, lpar1.L antibody
    Background

    Background: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA, this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

    Aliases: 5031439C20 antibody, AI326300 antibody, EDG 2 antibody, EDG2 antibody, Endothelial differentiation gene 2 antibody, Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2 antibody, GPCR 26 antibody, Gpcr26 antibody, Gpcr91 antibody, GPR26 antibody, Kdt2 antibody, LPA 1 antibody, LPA receptor 1 antibody, LPA receptor EDG2 antibody, LPA-1 antibody, lpA1 antibody, Lpar1 antibody, LPAR1_HUMAN antibody, Lysophosphatidic acid receptor 1 antibody, Lysophosphatidic acid receptor Edg-2 antibody, Lysophosphatidic acid receptor EDG2 antibody, MGC105279 antibody, MGC29102 antibody, Mrec1.3 antibody, rec.1.3 antibody, Ventricular zone gene 1 antibody, vzg-1 antibody, VZG1 antibody

    UniProt
    Q92633
    Pathways
    Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
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