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anti-M-Phase phosphoprotein 8 (MPHOSPH8) Antibodies

Involved in transcriptional regulation. Additionally we are shipping M-Phase phosphoprotein 8 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MPHOSPH8 54737 Q99549
MPHOSPH8 290270 G3V8T1
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Top anti-M-Phase phosphoprotein 8 Antibodies at

Showing 10 out of 18 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB MPP8 antibody (mAb) tested by Western blot. Nuclear extract of HEK293 cells (20 µg per lane) probed with MPP8 antibody (mAb) (2 µg/ml dilution). 100 μg Log in to see 1 to 2 Days
Human Mouse Un-conjugated IF, WB Western Blot analysis of MPHOSPH8 expression in transfected 293T cell line by MPHOSPH8 MaxPab polyclonal antibody.Lane 1: MPHOSPH8 transfected lysate(28.40 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to MPHOSPH8 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Log in to see 9 Days
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 9 to 11 Days
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated WB   100 μL Log in to see 11 to 16 Days
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 5 to 7 Days
Human Mouse Un-conjugated WB   10 μg Log in to see 1 to 2 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB   0.1 mL Log in to see 8 to 11 Days

MPHOSPH8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)

Rat (Rattus)

More Antibodies against M-Phase phosphoprotein 8 Interaction Partners

Human M-Phase phosphoprotein 8 (MPHOSPH8) interaction partners

  1. findings demonstrate MPP8 and SIRT1 (show SIRT1 Antibodies) reciprocally regulate each other's function at multiple molecular layers through physical interaction; disruption of MPP8-SIRT1 (show SIRT1 Antibodies) interaction de-represses E cadherin (show CDH1 Antibodies) expression and reduces cell motility and invasiveness suggesting this interplay plays critical role in MPP8- and SIRT1 (show SIRT1 Antibodies)-mediated epithelial-mesenchymal transition

  2. this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin (show PPHLN1 Antibodies); this complex is absent from Drosophila but is conserved from fish to humans.

  3. Knockdown analysis of MPP8 in HeLa cells resulted in derepression of a set of genes that are normally expressed in spermatogonia, spermatids and mature sperm, thereby indicating a role for this molecule in silencing testis-related genes in somatic cells.

  4. interaction of HN with MPP8 may play a role in oncogenesis because MPP8 increases tumor cell motility and invasion

  5. these results indicate that the chromatin association of MPP8 is regulated by Cdk (show CDK4 Antibodies)-dependent phosphorylation.

  6. These findings reveal the molecular mechanism of selective binding of human MPP8 chromodomain to methylated histone H3K9.

  7. We determined the crystal structure of MPP8 chromodomain in complex with H3K9me3 peptide. MPP8 interacts with at least six histone H3 (show HIST3H3 Antibodies) residues from glutamine (show GFPT1 Antibodies) 5 to serine 10.

  8. MPP8 mediates E-cadherin (show CDH1 Antibodies) gene silencing and promotes breast tumour cell motility and invasion.

M-Phase phosphoprotein 8 (MPHOSPH8) Antigen Profile

Protein Summary

Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites\; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression (By similarity).

Gene names and symbols associated with MPHOSPH8

  • M-phase phosphoprotein 8 (MPHOSPH8) antibody
  • M-phase phosphoprotein 8 (Mphosph8) antibody
  • 1500035L22Rik antibody
  • 4930548G07Rik antibody
  • Ab2-008 antibody
  • AU040635 antibody
  • HSMPP8 antibody
  • mpp8 antibody
  • RGD1305133 antibody
  • TWA3 antibody

Protein level used designations for MPHOSPH8

M-phase phosphoprotein, mpp , M-phase phosphoprotein, mpp8 , two hybrid-associated protein 3 with RanBPM

54737 Homo sapiens
75339 Mus musculus
290270 Rattus norvegicus
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