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HLA-C belongs to the HLA class I heavy chain paralogues. Additionally we are shipping Major Histocompatibility Complex Class I C Antibodies (68) and Major Histocompatibility Complex Class I C Proteins (33) and many more products for this protein.
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Recurrent Pregnancy Loss in Women with Killer Cell Immunoglobulin-Like Receptor KIR2DS1 (show KIR2DS1 ELISA Kits) is Associated with an Increased HLA-C2 Allelic Frequency
HLA-C genetic polymorphism is associated with psoriasis.
HLA-C2 and -C1, showed highly significant associations with CRC (show CALR ELISA Kits) development.
Therefore, the results obtained in this study demonstrate the involvement of HLA class I (show MICA ELISA Kits) genes in the susceptibility or resistance to American cutaneous leishmaniasis (ACL (show ACLY ELISA Kits)), with significant association between HLA-C*04 and ACL (show ACLY ELISA Kits) susceptibility.
four amino-acid positions of HLA-B and -C account for most of the associations between ankylosing spondylitis and MHC in the Korean population
HLA-C expressed on HIV-infected cells restricts attack by KIR2DL(+) CD56 (show NCAM1 ELISA Kits)(dim) natural killer (NK) cells
Absence of HLA-C2 for donor KIR2DL1 (show KIR2DL1 ELISA Kits) was associated with higher grade II to IV (HR, 1.4; P = .002) and III to IV acute GVHD (HR, 1.5; P = .01) compared with HLA-C2(+) patients.
The authors have identified a deleterious effect of the KIR2DL3-HLA-C1 receptor-ligand combination on HIV clinical outcomes in a Thai cohort.
HLA-C -35 C/C allele exerts a favorable effect on the immunological (higher baseline and nadir CD4 (show CD4 ELISA Kits)+ T cell count) and virologic (lower pretreatment HIV viral load) variables.
Preformed anti-HLA-Cw and anti-HLA-DP donor specific antibodies have deleterious impact in kidney transplantation.
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
HLA class I histocompatibility antigen, C alpha chain
, HLA class I histocompatibility antigen, Cw-1 alpha chain
, MHC class I antigen heavy chain HLA-C
, human leukocyte antigen-C alpha chain
, major histocompatibility antigen HLA-C