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HLA-C Products

(Major Histocompatibility Complex Class I C (HLA-C))

Categories

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008].

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Featured HLA-C Categories

HLA-C Antibodies

High quality antibodies with extensive validation data.

HLA-C ELISA Kits

Reliable ELISA kits for a wide range of species.

HLA-C Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HLA-C Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7434662
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (5)
Cat. No. ABIN7155625
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7155571
Quantity 100 μg
Datasheet Datasheet

Recommended HLA-C ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968422
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962562
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1571212
Quantity 96 tests
Datasheet Datasheet

Recommended HLA-C Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123828
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN2752815
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3087860
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our HLA-C products

Huang, Malu, McKenzie, Andrews, Talukder, Tieu, Karpinets, Haymaker, Forget, Williams, Wang, Mbofung, Wang, Davis, Lo, Wargo, Davies, Bernatchez, Heffernan, Amaria, Korkut, Peng, Roszik, Lizée et al.: "The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression. ..." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 14, pp. 3366-3376, (2018) (PubMed).

Apps, Qi, Carlson, Chen, Gao, Thomas, Yuki, Del Prete, Goulder, Brumme, Brumme, John, Mallal, Nelson, Bosch, Heckerman, Stein, Soderberg, Moody, Denny, Zeng, Fang, Moffett, Lifson, Goedert et al.: "Influence of HLA-C expression level on HIV control. ..." in: Science (New York, N.Y.), Vol. 340, Issue 6128, pp. 87-91, (2013) (PubMed).

Corrah, Goonetilleke, Kopycinski, Deeks, Cohen, Borrow, McMichael, Brackenridge: "Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression." in: Journal of virology, Vol. 85, Issue 7, pp. 3367-74, (2011) (PubMed).

Braud, Allan, Wilson, McMichael: "TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide." in: Current biology : CB, Vol. 8, Issue 1, pp. 1-10, (1998) (PubMed).

Synonyms and alternative names related to HLA-C

major histocompatibility complex, class I, C (HLA-C), D6S204, HLA-JY3, HLC-C, PSORS1

Protein level used designations for HLA-C

  • HLA class I histocompatibility antigen, C alpha chain
  • HLA class I histocompatibility antigen, Cw-1 alpha chain
  • MHC class I antigen heavy chain HLA-C
  • human leukocyte antigen-C alpha chain
  • major histocompatibility antigen HLA-C
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