Matrix Metallopeptidase 1 (Interstitial Collagenase) Proteins (MMP1)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP1 Antibodies (332) and MMP1 Kits (129) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP1 4312 P03956
Mouse MMP1 MMP1 17386 P33435
MMP1 300339  
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Top MMP1 Proteins at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$272.80
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$205.80
Details
HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$920.00
Details
HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$229.85
Details
HEK-293 Cells Human His tag Human MMP-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
$341.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$313.50
Details
Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$229.85
Details
Human Human Un-conjugated 10 μg Log in to see 6 to 7 Days
$440.82
Details

MMP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, ,
Rat (Rattus)

Top referenced MMP1 Proteins

  1. Human MMP1 Protein expressed in Human Cells - ABIN2003013 : Desrochers, Jeffrey, Weiss: Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. in The Journal of clinical investigation 1991 (PubMed)
    Show all 5 Pubmed References

More Proteins for Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaction Partners

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. results suggest that MMP1-1607 1G/2G, MMP3 (show MMP3 Proteins)-1171 5A/6A and MMP9 (show MMP9 Proteins)-1562 C/T gene polymorphisms have synergistic effect on breast cancer. The interactions of MMPs clinical risk factors such as lymph node involvement has shown a strong correlation and might influence the 5-years survival rate, suggesting their potential role in the breast carcinogenesis

  2. The MMP-1 -1607 (2G/1G) and -519 (A/G) polymorphisms may contribute to the onset of osteomyelitis. The 2G/2G genotype carriers had 1.605 times risk of developing osteomyelitis. In addition, frequency of -519GG genotype was obviously higher in case group than that in control group, and GG genotype related to an increased risk of osteomyelitis. Whereas, the -519G allele may be a susceptible factor for osteomyelitis.

  3. No differences in the distribution of the MMP-1 variants were found among Tunisian chronic obstructive pulmonary disease patients and healthy controls. Additionally, no significant association was retrieved between clinicopathologic parameters of chronic obstructive pulmonary disease, MMP-1 levels and this polymorphism.

  4. In American cutaneous leishmaniasis caused by Leishmania braziliensis infection, MMP1 is regulated by factors other than FLI1 (show FLI1 Proteins), and the influence of IL-6 (show IL6 Proteins) on MMP1 was independent of its effect on FLI1 (show FLI1 Proteins).

  5. MMP1 was produced in the tumor compartment of prostate cancer bone metastases, highlighting its accessibility to KLK4 (show KLK4 Proteins) at this site

  6. EREG (show EREG Proteins) and MMP-1 were found to be elevated in nasal polyp and uncinate tissues in patients with Chronic rhinosinusitis with nasal polyps.

  7. IL-21 (show IL17C Proteins) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 and MMP-3 (show MMP3 Proteins).

  8. Data indicate that MMP1, MMP12 (show MMP12 Proteins) and PPARG (show PPARG Proteins) and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-31-5p, hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-224-5p, and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity.

  9. we infer that Slug enhances MMP1 transcription via directly binding to the promoter region in breast cancer cells, which is a previously unrecognized mechanism in the development of multi-drug resistance.

  10. Increased levels of MMP1 and MMP12 (show MMP12 Proteins) on tumor-associated macrophages in the peripheral areas of dermatofibrosarcoma protuberance might contribute to local invasion

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. the identification of MMP1 and MMP10 (show MMP10 Proteins) genes in swine is reported.

  2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1

  3. Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1, MMP-3 (show MMP3 Proteins), and TIMP-1 (show TIMP1 Proteins) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. Data indicate that matrix metalloproteinases mmp1 and mmp2 (show MMP2 Proteins) mutants have distinct heart phenotypes.

  2. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  3. A primary function of Mmp1, under the control of the JNK (show MAPK8 Proteins) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

  4. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (show GUSB Proteins) homeostasis

  5. Study identified three genes, regeneration (rgn (show RGN Proteins)), augmenter of liver regeneration (alr (show GFER Proteins)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Mouse (Murine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. data reveal a novel involvement of MMP-13 (show MMP13 Proteins) in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (show CCL1 Proteins) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (show CD8A Proteins)(+) T-cell response in vitro; MMP-13 (show MMP13 Proteins) might be a promising target for therapeutic intervention in inflammatory diseases

  2. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (show DDR2 Proteins)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (show DDR2 Proteins) and matrix metalloproteinase 13 (show MMP13 Proteins).

  3. Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 Proteins) with an inducible Col2a1 (show COL2A1 Proteins)-Cre caused premature production of pErk1/2 and Mmp13 (show MMP13 Proteins) in the growth plate.

  4. Mmp13 (show MMP13 Proteins) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH Proteins), and Osterix (show SP7 Proteins) through distal enhancers.

  5. Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Proteins) in OA and highlights the HIF1alpha (show HIF1A Proteins)-beta-catenin (show CTNNB1 Proteins) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

  6. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1/protease-activated receptor-1 (show F2R Proteins) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  7. IL-1Ra (show IL1RN Proteins) is associated with MMP-13 (show MMP13 Proteins) expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Proteins) signaling cascade.

  8. We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 (show MMP13 Proteins) expression and activity.

  9. B-16 melanoma cells with up-regulated MMP-13 (show MMP13 Proteins) expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 (show MMP13 Proteins) expression also decreased invading cell numbers.

  10. MMP-12 (show MMP12 Proteins) and MMP-13 (show MMP13 Proteins) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA (show RBM9 Proteins), leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.

  2. The expression patterns of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

  3. Data suggest that luteolytic factors (such as interferon gamma (show IFNG Proteins), tumor necrosis factor alpha (show TNF Proteins), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  4. The results showed that a decrease in MMP-1 and MMP-2 (show MMP2 Proteins) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

  5. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

  6. MMP-1 promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Proteins) and activation of NF-kappaB (show NFKB1 Proteins)

  7. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  8. the differential expression and localization of membrane-type 1 matrix metalloproteinase (show MMP14 Proteins) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (show MMP2 Proteins)

  9. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (show MMP13 Proteins) (follicular apex (show APEX1 Proteins) vs. base) for the preovulatory collagenolysis required for follicle rupture

  10. identification of MT1-MMP (show MMP14 Proteins) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. These results suggest that PEP-1-SIRT2 (show SIRT2 Proteins) promotes matrix metalloproteinases-induced dedifferentiation via ERK (show MAPK1 Proteins) signaling in articular chondrocytes. .

  2. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (show TIMP3 Proteins) secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. ANXA2 (show ANXA2 Proteins) and MMP1 might participate in remodeling during wound healing in the horse.

  2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

  3. These results suggest that MMP-1 and IL-8 (show IL8 Proteins) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

MMP1 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with MMP1

  • matrix metallopeptidase 1 (MMP1)
  • Matrix metalloproteinase 1 (Mmp1)
  • matrix metalloproteinase 1 (RB11133)
  • matrix metalloproteinase 1 (Mmp1)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metallopeptidase 1 (interstitial collagenase) (MMP1)
  • matrix metallopeptidase 1 S homeolog (mmp1.S)
  • interstitial collagenase (MMP-1)
  • interstitial collagenase (LOC100727966)
  • matrix metallopeptidase 1 (Mmp1)
  • CG4859 protein
  • Clg protein
  • Clgn protein
  • col4 protein
  • dm1-MMP protein
  • Dmel\\CG4859 protein
  • dmmp1 protein
  • l(2)k04809 protein
  • MMP-1 protein
  • MMP-13 protein
  • Mmp1 protein
  • Mmp 1 protein
  • Mmp1a protein
  • mmp18 protein

Protein level used designations for MMP1

fibroblast collagenase , interstitial collagenase , matrix metalloprotease 1 , matrix metalloproteinase 1 , MMP-1 , matrix metalloproteinase 1 (type I collagenase) , matrix metalloproteinase-1 , CG4859-PC , CG4859-PD , CG4859-PE , CG4859-PF , CG4859-PG , CG4859-PH , CG4859-PI , CG4859-PJ , CG4859-PK , CG4859-PL , Mmp1-PC , Mmp1-PD , Mmp1-PE , Mmp1-PF , Mmp1-PG , Mmp1-PH , Mmp1-PI , Mmp1-PJ , Mmp1-PK , Mmp1-PL , Collagenase-3 , collagenase 3 , collagenase-1 , matrix metalloproteinase 13 , matrix metalloproteinase-13 , MMP-18 , collagenase-4 , matrix metalloproteinase-18 , xCol4 , matrix metallopeptidase 1a , matrix metalloproteinase 1a (interstitial collagenase) , myocardial collagenase

GENE ID SPECIES
4312 Homo sapiens
397320 Sus scrofa
37949 Drosophila melanogaster
1790862 Rhodopirellula baltica SH 1
100144547 Bombyx mori
17386 Mus musculus
281308 Bos taurus
100009110 Oryctolagus cuniculus
489428 Canis lupus familiaris
100033896 Equus caballus
495287 Xenopus laevis
443463 Ovis aries
101120355 Ovis aries
100727966 Cavia porcellus
300339 Rattus norvegicus
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