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Matrix Metallopeptidase 1 (Interstitial Collagenase) Proteins (MMP1)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP1 Antibodies (334) and MMP1 Kits (105) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP1 4312 P03956
Mouse MMP1 MMP1 17386 P33435
MMP1 432357  
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Top MMP1 Proteins at

Showing 10 out of 49 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
HOST_HEK-293 Cells Human His tag Human MMP-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
HOST_Human Human Un-conjugated 10 μg Log in to see 5 to 6 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
HOST_Human Human His tag   10 μg Log in to see 11 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days

MMP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
Rat (Rattus)

Top referenced MMP1 Proteins

  1. Human MMP1 Protein expressed in Human Cells - ABIN2003013 : Desrochers, Jeffrey, Weiss: Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. in The Journal of clinical investigation 1991 (PubMed)
    Show all 5 references for ABIN2003013

  2. Human MMP1 Protein expressed in HEK-293 - ABIN2666521 : Mazor, Alsaigh, Shaked, Altshuler, Pocock, Kistler, Karin, Schmid-Schönbein: Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. in The Journal of biological chemistry 2013 (PubMed)
    Show all 5 references for ABIN2666521

More Proteins for Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  2. A primary function of Mmp1, under the control of the JNK (show MAPK8 Proteins) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

  3. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (show GUSB Proteins) homeostasis

  4. Study identified three genes, regeneration (rgn (show RGN Proteins)), augmenter of liver regeneration (alr (show GFER Proteins)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. The 1G allele of matrix metallopeptidase (show ECEL1 Proteins) 1 (MMP1) promoter 1607 may have a protective effect on hepatocellular carcinoma (HCC (show FAM126A Proteins)) risk for non-smokers in Taiwan.

  2. The status of a carrier of mutated (G insertion) allele with regard to the 1G/2G polymorphism at position -1607 within the MMP1 gene may determine a pathological phenotype associated with a more severe clinical course of chronic rhinosinusitis with nasal polyps

  3. Study investigated the association between MMP-1 -1607 1G/2G and MMP-3 (show MMP3 Proteins) -1171 5A/6A genetic polymorphisms and etiological subtypes of ischemic stroke (IS) in the Han Chinese population; MMP-1 2G allele was associated with IS due to SAO, whereas patients with IS due to LAA were more likely carriers of the 5A variant in MMP-3 (show MMP3 Proteins)

  4. this study shows that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase (show MMP20 Proteins) inhibitor (MMPI) could suppress sICOSL production

  5. In order to reveal the structural and conformational effects of mutations, a molecular dynamics (MD) study was performed of in silico mutated residues in the X-ray crystallographic structure of MMP-1 complexed with a collagen-model triple-helical peptide (THP (show UMOD Proteins)). The results indicate an important role of the mutated residues in MMP-1 interactions with the THP (show UMOD Proteins) and communication between the catalytic and the HPX (show HPX Proteins) domains.

  6. A significant association has been found between MMP-1 -1607 1G/2G polymorphism and the susceptibility of endometriosis and adenomyosis under recessive model, while no significant association was found for MMP-2 (show MMP2 Proteins) -735 C/T, MMP-3 (show MMP3 Proteins) -1171 5A/6A and MMP-9 (show MMP9 Proteins) -1562 C/T polymorphisms. (Meta-analysis)

  7. infiltrative pulmonary tuberculosis is characterized by impairements in the system MMP/inhibitors: the levels of MMP-1, -9 increased, MMP-3 (show MMP3 Proteins), -8, TIMP-1 (show TIMP1 Proteins) remained at the reference values and a 2-macroglobulin was low.

  8. Serum MMP-1 level showed a possibility as a prognostic biomarker in non-small cell lung cancer.

  9. Melatonin decreased CXCL10 (show CXCL10 Proteins) and MMP-1 production and increased TIMP-1 (show TIMP1 Proteins) production in IL-1beta (show IL1B Proteins)-stimulated Human Periodontal Ligament Cells

  10. MMP1 expression is significantly upregulated in human masticatory mucosa during wound healing

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. the identification of MMP1 and MMP10 (show MMP10 Proteins) genes in swine is reported.

  2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1

  3. Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1, MMP-3 (show MMP3 Proteins), and TIMP-1 (show TIMP1 Proteins) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. The expression patterns of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

  2. Data suggest that luteolytic factors (such as interferon gamma (show IFNG Proteins), tumor necrosis factor alpha (show TNF Proteins), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  3. The results showed that a decrease in MMP-1 and MMP-2 (show MMP2 Proteins) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

  4. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

  5. MMP-1 promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Proteins) and activation of NF-kappaB (show NFKB1 Proteins)

  6. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  7. the differential expression and localization of membrane-type 1 matrix metalloproteinase (show MMP14 Proteins) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (show MMP2 Proteins)

  8. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (show MMP13 Proteins) (follicular apex (show APEX1 Proteins) vs. base) for the preovulatory collagenolysis required for follicle rupture

  9. identification of MT1-MMP (show MMP14 Proteins) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

  10. MT1-MMP (show MMP14 Proteins) has a role in signaling events mediating EGFR (show EGFR Proteins) transactivation

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (show TIMP3 Proteins) secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. ANXA2 (show ANXA2 Proteins) and MMP1 might participate in remodeling during wound healing in the horse.

  2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

  3. These results suggest that MMP-1 and IL-8 (show IL8 Proteins) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

Mouse (Murine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Proteins) in OA and highlights the HIF1alpha (show HIF1A Proteins)-beta-catenin (show CTNNB1 Proteins) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

  2. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1/protease-activated receptor-1 (show F2R Proteins) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  3. IL-1Ra (show IL1RN Proteins) is associated with MMP-13 (show MMP13 Proteins) expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Proteins) signaling cascade.

  4. We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 (show MMP13 Proteins) expression and activity.

  5. B-16 melanoma cells with up-regulated MMP-13 (show MMP13 Proteins) expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 (show MMP13 Proteins) expression also decreased invading cell numbers.

  6. MMP-12 (show MMP12 Proteins) and MMP-13 (show MMP13 Proteins) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

  7. Data indicate that tamoxifen decreased collage type II COL2A1 (show COL2A1 Proteins) by activating matrix metallopeptidases MMP-2 (show MMP2 Proteins)/13 expression.

  8. This study demonstrates that stromal as well as tumor derived MMP13 (show MMP13 Proteins) contribute to tumor cell extravasation and establishment of metastases in the liver microenvironment.

  9. Elevated MMP13 (show MMP13 Proteins) activity may contribute to Pseudomonas aeruginosa keratitis through basement membrane degradation.

  10. Mmp13 (show MMP13 Proteins) gene is regulated via at least three specific distal enhancers that display independent activities yet are able to integrate response from multiple signaling pathways in a model of activation and suppression.

MMP1 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with MMP1

  • Matrix metalloproteinase 1 (Mmp1)
  • matrix metalloproteinase 1 (RB11133)
  • matrix metalloproteinase 1 (Mmp1)
  • interstitial collagenase (MMP-1)
  • matrix metallopeptidase 1 (interstitial collagenase) (MMP1)
  • matrix metallopeptidase 1 (interstitial collagenase) (mmp1)
  • matrix metallopeptidase 1 (interstitial collagenase) (Mmp1)
  • matrix metallopeptidase 13 (Mmp13)
  • CG4859 protein
  • Clg protein
  • Clgn protein
  • col4 protein
  • dm1-MMP protein
  • Dmel\\CG4859 protein
  • dmmp1 protein
  • l(2)k04809 protein
  • MMP-1 protein
  • MMP-13 protein
  • Mmp1 protein
  • Mmp 1 protein
  • Mmp1a protein
  • mmp18 protein

Protein level used designations for MMP1

CG4859-PC , CG4859-PD , CG4859-PE , CG4859-PF , CG4859-PG , CG4859-PH , CG4859-PI , CG4859-PJ , CG4859-PK , CG4859-PL , Mmp1-PC , Mmp1-PD , Mmp1-PE , Mmp1-PF , Mmp1-PG , Mmp1-PH , Mmp1-PI , Mmp1-PJ , Mmp1-PK , Mmp1-PL , matrix metalloprotease 1 , matrix metalloproteinase 1 , matrix metalloproteinase-1 , fibroblast collagenase , interstitial collagenase , MMP-1 , matrix metalloproteinase 1 (type I collagenase) , collagenase-1 , MMP-18 , collagenase-4 , matrix metalloproteinase-18 , xCol4 , Collagenase-3 , collagenase 3 , matrix metalloproteinase 13 , matrix metalloproteinase-13

37949 Drosophila melanogaster
1790862 Rhodopirellula baltica SH 1
100144547 Bombyx mori
443463 Ovis aries
4312 Homo sapiens
397320 Sus scrofa
281308 Bos taurus
100009110 Oryctolagus cuniculus
100033896 Equus caballus
489428 Canis lupus familiaris
101120355 Ovis aries
495287 Xenopus laevis
100727966 Cavia porcellus
17386 Mus musculus
432357 Rattus norvegicus
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