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Matrix Metalloproteinase 2 Proteins (MMP2)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP2 Antibodies (374) and MMP2 Kits (112) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP2 81686 P33436
MMP2 17390 P33434
MMP2 4313 P08253
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Top MMP2 Proteins at

Showing 10 out of 46 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Mouse Un-conjugated 25 μg Log in to see 10 to 12 Days
HOST_HEK-293 Cells Human His tag Human MMP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 50 μg Log in to see 2 to 3 Days
Mouse Mouse Un-conjugated 5 μg Log in to see 2 to 3 Days
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
HOST_Human Cells Human Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days

MMP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,
Mouse (Murine) , , ,

Human , , , , , , ,

Top referenced MMP2 Proteins

  1. Human MMP2 Protein expressed in HEK-293 - ABIN2666503 : Itoh, Ikeda, Gomi, Nakao, Suzuki, Itohara: Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. in The Journal of biological chemistry 1997 (PubMed)
    Show all 7 references for ABIN2666503

  2. Human MMP2 Protein expressed in Human Cells - ABIN2002031 : Brooks, Silletti, von Schalscha, Friedlander, Cheresh: Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. in Cell 1998 (PubMed)
    Show all 7 references for ABIN2002031

  3. Mouse (Murine) MMP2 Protein expressed in HEK-293 - ABIN2666506 : Hoikkala, Pääkkö, Soini, Mäkitaro, Kinnula, Turpeenniemi-Hujanen: Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2--complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma. in Cancer letters 2006 (PubMed)
    Show all 7 references for ABIN2666506

  4. Human MMP2 Protein expressed in HEK-293 Cells - ABIN2181511 : Fernandez-Patron, Radomski, Davidge: Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. in Circulation research 1999 (PubMed)
    Show all 5 references for ABIN2181511

  5. Mouse (Murine) MMP2 Protein expressed in Human Cells - ABIN2008781 : Fernandez-Patron, Stewart, Zhang, Koivunen, Radomski, Davidge: Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. in Circulation research 2000 (PubMed)
    Show all 5 references for ABIN2008781

  6. Human MMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1080273 : Zheng, Hu, Huang, Xu, Yang, Li: In vivo bioengineered ovarian tumors based on collagen, matrigel, alginate and agarose hydrogels: a comparative study. in Biomedical materials (Bristol, England) 2015 (PubMed)

  7. Mouse (Murine) MMP2 Protein expressed in Mouse - ABIN593510 : Masui, Doi, Koshiba, Fujimoto, Tsuji, Nakajima, Koizumi, Toyoda, Tulachan, Ito, Kami, Mori, Wada, Noda, Imamura: RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. in Clinical cancer research : an official journal of the American Association for Cancer Research 2003 (PubMed)

More Proteins for Matrix Metalloproteinase 2 (MMP2) Interaction Partners

Horse (Equine) Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. study demonstrated that matrix metalloproteinase 1 (show MMP1 Proteins) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development

Fruit Fly (Drosophila melanogaster) Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (show CA2 Proteins)+ as the second messenger.

  2. Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.

  3. As a Wnt (show WNT4 Proteins) signaling antagonist, MMP2 cleaves the glypican (show GPC1 Proteins), reducing the ability of Dlp (show DMD Proteins) to interact with the Wnt (show WNT4 Proteins) ligand and promote its distribution.

  4. Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila

  5. Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.

  6. Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes

  7. Mmp2 expression in the developing air sac (show ADCY10 Proteins) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.

  8. findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix

Zebrafish Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (show MMP9 Proteins) in the embryonic zebrafish.

Mouse (Murine) Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. MMP-2 potentiates shear-induced platelet activation by enhancing thrombus formation

  2. Identify novel MMP-2/cardiac sPLA2 (show PLA2G2A Proteins) pathway that endows the heart with important endocrine functions, including regulation of inflammation and lipid metabolism in the liver.

  3. 129/SvEv mice are more susceptible to abdominal aortic aneurysms compared to C57Bl/6 mice and suggest roles for MMP2/9.

  4. Report cross-talk between macrophages, smooth muscle cells, and endothelial cells in response to cigarette smoke alters MMP2/9 levels.

  5. MMP-2 silenced hypoxic fibroblasts under hyperglycemic conditions have impaired angiogenic potential. Collagen I/IV secretion is decreased and cell migration is prevented.

  6. N-terminal truncated isoform-MMP-2, but not full-length-MMP-2, is the major isoform of MMP-2 involved in skeletal muscle Ischemia-reperfusion injury.

  7. These data indicate that oxygen-glucose deprivation-triggered Cav-1 (show CAV1 Proteins) S-nitrosylation interacts with tPA (show PLAT Proteins)-induced ERK (show EPHB2 Proteins) activation to augment MMP2 and 9 secretion and subsequent extracellular matrix degradation.

  8. Type IV collagenases, MMP-2 and MMP-9 (show MMP9 Proteins), play important roles in hair cycle, and this could be mediated by induced expression of VEGF (show VEGFA Proteins), IGF-1 (show IGF1 Proteins), and TGF-beta (show TGFB1 Proteins).

  9. Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction

  10. Early MMP-2/MMP-9 (show MMP9 Proteins) activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse.

Human Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. these findings indicated that HMGB1 (show HMGB1 Proteins) promoted hepatocellular carcinoma progression partly by enhancing the ERK1/2 and NF-kappaB (show NFKB1 Proteins) pathways, upregulating MMP-2, and downregulating p21 (show CDKN1A Proteins) via an ERK (show EPHB2 Proteins)/c-Myc (show MYC Proteins) pathway

  2. Data show that ADAM9 (show ADAM9 Proteins) silencing affected MMP2 and ADAM15 (show ADAM15 Proteins) expression.

  3. miR (show MLXIP Proteins)-125b might inhibit keratinocyte proliferation and promote keratinocyte apoptosis in oral lichen planus pathogenesis by targeting MMP-2 through PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway.

  4. Curcumin induces SHI (show MBP Proteins)-1 cell apoptosis, possibly via both intrinsic and extrinsic pathways triggered by JNK (show MAPK8 Proteins), P38 MAPK (show MAPK14 Proteins) and ERK (show EPHB2 Proteins) signaling, but also partially suppresses SHI (show MBP Proteins)-1 cell invasion, likely by reducing the levels of transcription and secretion of MMP-2 and MMP-9 (show MMP9 Proteins).

  5. CXCL10 (show CXCL10 Proteins)/CXCR3 (show CXCR3 Proteins) axis promotes gastric cancer cell invasion and migration by upregulating MMP-2 and MMP-9 (show MMP9 Proteins) production via PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.

  6. overexpression of LATS2 resulted in mobility inhibition in non-small cell lung cancer cell lines A549 and H1299, and reduced protein level of matrix metalloproteinase-2 (MMP-2) and MMP-9 (show MMP9 Proteins).

  7. MMP-2 C-735T polymorphism is associated with increased risk of breast cancer.

  8. The results suggest that MMP2, MMP7 (show MMP7 Proteins) and MMP9 (show MMP9 Proteins) promoter polymorphisms play a role as one of the key modulators of the risk of developing colorectal cancer in Kashmiri population.

  9. The rs3918242 MMP-9 (show MMP9 Proteins) and rs2285053 MMP-2 single nucleotide polymorphisms might represent useful biomarkers and targets for preventing and monitoring mitral valve diseases

  10. MMP-2 was significantly associated with exercise capacity, ventilatory efficiency and left ventricular deceleration time, independently of age, sex, body surface area and NT-proBNP. MMP-2 may provide new information in the clinical evaluation of adults with congenital heart disease.

Cow (Bovine) Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. The expression patterns of MMP1 (show MMP1 Proteins), MMP2, and MMP8 (show MMP8 Proteins) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1 (show MMP1 Proteins), MMP2, and MMP8 (show MMP8 Proteins) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1 (show MMP1 Proteins), MMP2, and MMP8 (show MMP8 Proteins) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

  2. The results showed that a decrease in MMP-1 (show MMP1 Proteins) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

  3. Activation of cytosolic MMP-9 (show MMP9 Proteins) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.

  4. Data indicate the involvement of PKC-alpha (show PKCa Proteins) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Proteins) expression by NF-kappaB (show NFKB1 Proteins)-MT1-MMP (show MMP14 Proteins)-dependent and -independent pathway.

  5. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (show MMP14 Proteins)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.

  6. Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase activity, but the pretreatment with TIMP-2 (show TIMP2 Proteins) inhibits the increase in the enzyme activity

  7. A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.

  8. MMP-14 (show MMP14 Proteins), MMP-2 and TIMP-2 (show TIMP2 Proteins) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  9. Results describe distinct changes in expression of MMP2, MMP14 (show MMP14 Proteins), and the metallopeptidase (show ECEL1 Proteins) inhibitor TIMP2 (show TIMP2 Proteins) between different phases of the estrous cycle indicating an endocrine regulation.

  10. EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 and MMP-14 (show MMP14 Proteins) suggesting a role in adhesion and fusion of embryo to luminal epithelium.

Pig (Porcine) Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Proteins), TIMP1 (show TIMP1 Proteins), and NGAL (show LCN2 Proteins) (also MMP2 in 220 kDa complex) without proteolytic activity.

  2. Data demonstrate for the first time that MMP2 and MMP9 (show MMP9 Proteins) are expressed in swine ovarian follicle both in theca and granulosa layers.

  3. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2, caspase-3 (show CASP3 Proteins) and BDNF (show BDNF Proteins)

  4. MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions

  5. Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.

  6. PI3K-dependent regulation of MT1-MMP (show MMP14 Proteins) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.

  7. MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis

  8. contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Proteins) barrier in vitro

  9. The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (show MMP9 Proteins) in the corpus luteum of swine during luteolysis are reported.

  10. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2, VEGFR-1 (show FLT1 Proteins), VEGFR-2 (show KDR Proteins), and TIMP-1 (show TIMP1 Proteins), which may contribute to the development of venous stenosis.

Rabbit Matrix Metalloproteinase 2 (MMP2) interaction partners

  1. Inflammatory factors such as TNF-alpha (show TNF Proteins) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases

  2. Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.

  3. In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (show DMD Proteins).

  4. Castor oil polymer induces bone formation with high matrix metalloproteinase-2 expression.

  5. MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.

  6. Ulinastatin (show AMBP Proteins) effectively inhibited the increased expression of MMP-2, MMP-3 (show MMP3 Proteins), and iNOS (show NOS2 Proteins) in degenerated NP cells induced by IL-1beta (show IL1B Proteins) in vitro.

  7. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (show MMP9 Proteins) and TIMP-1 (show TIMP1 Proteins) in rabbits with acute paraquat poisoning.

  8. The RNA interference targeting COX-2 can effectively inhibit the expression of COX-2 and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.

  9. Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.

MMP2 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MMP2

  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2)
  • Matrix metalloproteinase 2 (Mmp2)
  • matrix metalloproteinase 2 (mmp2)
  • matrix metalloproteinase-2 (mmp-2)
  • matrix metalloproteinase 2 (Mmp-2)
  • matrix metalloproteinase-2 (LOC100135793)
  • matrix metallopeptidase 2 (Mmp2)
  • 2-MMP protein
  • anon-WO0118547.84 protein
  • CG1794 protein
  • CLG4 protein
  • CLG4A protein
  • dm-2MMP protein
  • Dm2-MMP protein
  • Dmel\\CG1794 protein
  • dmmp2 protein
  • fgmmp-2 protein
  • GelA protein
  • l(2)02353 protein
  • LOC100135793 protein
  • MMP-2 protein
  • MMP-II protein
  • mmp2 protein
  • MONA protein
  • TBE-1 protein
  • wu:fa99h12 protein
  • wu:fk89d01 protein

Protein level used designations for MMP2

CG1794-PB , CG1794-PC , CG1794-PD , Mmp2-PB , Mmp2-PC , Mmp2-PD , matrix metalloprotease 2 , matrix metalloproteinase , matrix metalloproteinase 2 , 72 kDa type IV collagenase , Gelatinase A , matrix metalloproteinase-2 , 72 kDa gelatinase , MMP-2 , gelatinase A , 72kD gelatinase , 72kD type IV collagenase , 72kDa gelatinase , 72kDa type IV collagenase , collagenase type IV-A , matrix metalloproteinase-II , neutrophil gelatinase , matrix metalloproteinase 2 (72 KDa type IV collagenase) , matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

100033948 Equus caballus
35997 Drosophila melanogaster
337179 Danio rerio
653022 Takifugu rubripes
657982 Tribolium castaneum
100135793 Oncorhynchus mykiss
81686 Rattus norvegicus
17390 Mus musculus
4313 Homo sapiens
282872 Bos taurus
386583 Gallus gallus
403733 Canis lupus familiaris
397391 Sus scrofa
100009000 Oryctolagus cuniculus
443115 Ovis aries
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