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MEFV encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Additionally we are shipping Mediterranean Fever Antibodies (62) and Mediterranean Fever Kits (5) and many more products for this protein.
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a guard-like mechanism of pyrin regulation, originally identified for Nod-like receptors in plant innate immunity, also exists in humans.
Most patients presenting with PFAPA syndrome have heterozygous MEFV gene mutations.
When compared with the control group, a lower prevalence of the MEFV gene mutation carrier was found in sarcoidosis patients but this was not statistically significant.
This is the first report of non-transmitted, acquired familial Mediterranean fever, associated with a Janus Kinase 2 (show JAK2 Proteins) driven clonal expansion of a somatic Mediterranean fever gene exon 10 mutation.
As colchicine treatment not only improved the myofascial pain but also prevented FMF-associated amyloidosis and nephropathy, differential diagnosis of fibromyalgia in patients of Mediterranean origin should include FMF and a genetic screening of MEFV.
MEFV mutations M694V and M680I are associated with Behcet's disease. [meta-analysis]
Carrier rate for MEFV mutations was lower in the SLE group, which is in agreement with previous observations that FMF may confer some protection from SLE. Exon 10 mutations were associated with SLE nephritis after the exclusion of the E148Q mutation.
There was no statistically significant difference between patients and controls in incidence of -1661 A/G single nucleotide polymorphism CTLA4 (show CTLA4 Proteins) nor with the clinical symptoms of Familial Mediterranean Fever and MEFV gene mutations.
The presence of M694V was found to be associated with more severe course of FMF, earlier age of onset and more frequent arthritis in the Syrian children with FMF compared to other FMF patients who do not have this mutation.
Among the MEFV gene mutations M694V (mainly) and also V726A and M680I were the most common ones
These results are consistent with a model in which pyrin acts to limit the release of IL-1beta (show IL1B Proteins) generated by activation and assembly of inflammasomes in response to subclinical immune challenges.
pyrin has a critical role in the innate immune response, possibly by acting on ASC (show STS Proteins), a known caspase-1 (show CASP1 Proteins) activator
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
Mediterranean fever protein
, Mediterranean fever
, familial mediterranean fever