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Mediterranean Fever Proteins (MEFV)

MEFV encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Additionally we are shipping Mediterranean Fever Antibodies (62) and Mediterranean Fever Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MEFV 4210 O15553
MEFV 54483 Q9JJ26
MEFV 58923 Q9JJ25
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Top Mediterranean Fever Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

MEFV Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Mediterranean Fever (MEFV) Interaction Partners

Human Mediterranean Fever (MEFV) interaction partners

  1. a guard-like mechanism of pyrin regulation, originally identified for Nod-like receptors in plant innate immunity, also exists in humans.

  2. Most patients presenting with PFAPA syndrome have heterozygous MEFV gene mutations.

  3. When compared with the control group, a lower prevalence of the MEFV gene mutation carrier was found in sarcoidosis patients but this was not statistically significant.

  4. This is the first report of non-transmitted, acquired familial Mediterranean fever, associated with a Janus Kinase 2 (show JAK2 Proteins) driven clonal expansion of a somatic Mediterranean fever gene exon 10 mutation.

  5. As colchicine treatment not only improved the myofascial pain but also prevented FMF-associated amyloidosis and nephropathy, differential diagnosis of fibromyalgia in patients of Mediterranean origin should include FMF and a genetic screening of MEFV.

  6. MEFV mutations M694V and M680I are associated with Behcet's disease. [meta-analysis]

  7. Carrier rate for MEFV mutations was lower in the SLE group, which is in agreement with previous observations that FMF may confer some protection from SLE. Exon 10 mutations were associated with SLE nephritis after the exclusion of the E148Q mutation.

  8. There was no statistically significant difference between patients and controls in incidence of -1661 A/G single nucleotide polymorphism CTLA4 (show CTLA4 Proteins) nor with the clinical symptoms of Familial Mediterranean Fever and MEFV gene mutations.

  9. The presence of M694V was found to be associated with more severe course of FMF, earlier age of onset and more frequent arthritis in the Syrian children with FMF compared to other FMF patients who do not have this mutation.

  10. Among the MEFV gene mutations M694V (mainly) and also V726A and M680I were the most common ones

Mouse (Murine) Mediterranean Fever (MEFV) interaction partners

  1. These results are consistent with a model in which pyrin acts to limit the release of IL-1beta (show IL1B Proteins) generated by activation and assembly of inflammasomes in response to subclinical immune challenges.

  2. pyrin has a critical role in the innate immune response, possibly by acting on ASC (show STS Proteins), a known caspase-1 (show CASP1 Proteins) activator

Mediterranean Fever (MEFV) Protein Profile

Protein Summary

This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.

Gene names and symbols associated with Mediterranean Fever Proteins (MEFV)

  • Mediterranean fever (MEFV)
  • Mediterranean fever (Mefv)
  • pyrin-like (LOC529195)
  • FMF protein
  • MEF protein
  • MEFV protein
  • pyrin protein
  • rfp domain protein
  • TRIM20 protein

Protein level used designations for Mediterranean Fever Proteins (MEFV)

Mediterranean fever protein , Mediterranean fever , pyrin-like , marenostrin , pyrin , familial mediterranean fever

467886 Pan troglodytes
701927 Macaca mulatta
100387055 Callithrix jacchus
100477997 Ailuropoda melanoleuca
100592337 Nomascus leucogenys
4210 Homo sapiens
490041 Canis lupus familiaris
54483 Mus musculus
58923 Rattus norvegicus
529195 Bos taurus
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