Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by MC4R is a membrane-bound receptor and member of the melanocortin receptor family. Additionally we are shipping Melanocortin 4 Receptor Kits (7) and Melanocortin 4 Receptor Proteins (6) and many more products for this protein.
Showing 10 out of 120 products:
Human Polyclonal MC4R Primary Antibody for EIA, IHC (p) - ABIN500250
Gantz, Miwa, Konda, Shimoto, Tashiro, Watson, DelValle, Yamada: Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. in The Journal of biological chemistry 1993
Human Polyclonal MC4R Primary Antibody for ICC, IHC - ABIN1742042
Gantz, Fong: The melanocortin system. in American journal of physiology. Endocrinology and metabolism 2003
MRAP2b decreases the constitutive activity of the MC4R during fasting periods, driving the animal toward a positive energy balance.
MRAP2 proteins allow for developmental control of MC4R activity, with MRAP2a blocking its function and stimulating growth during larval development, whereas MRAP2b enhances responsiveness to alpha-MSH once the zebrafish begins feeding, thus increasing the capacity for regulated feeding and growth.
FTO (show FTO Antibodies) rs9939609, MC4R rs17782313, and PPARgamma (show PPARG Antibodies) rs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men.
Epigenetic alterations of the newly identified genes MC4R and HNF4a (show HNF4A Antibodies) in early life might contribute to metabolic profile changes, especially increased triglyceride levels, in the cord blood of preterm infants.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC (show POMC Antibodies)), apolipoprotein E (APOE (show APOE Antibodies)) and agouti-related protein (AGRP (show AGRP Antibodies)) with obesity in the North Indian population.
Data provide evidence that variants of MC4R and LYPLAL1 (show LYPLAL1 Antibodies) modulate body fat distribution with sexual dimorphism in a Chinese population.
that the FTO rs9939609 and MC4R rs17782313 variants may be significantly associated with nocturnal but not daytime blood pressure levels and their combined effects were significant in this Chinese Han population
The prevalence of loss-of-function MC4R variants in obese Slovak children was 0.7 %, what is one of the lowest frequencies in Europe
MC4R mutations contribute to the onset of obesity.
this molecular analysis of a family-based study showed an autosomal dominant pattern. Our study indicated that MC4R variations in early-onset obese Thai children were found, and transmission of these variations in each family is in the dominant pattern
The MC4R variant (rs12970134) was associated with increased risk for obesity in Czech women.
Uncontrolled eating scores were higher in C-allele carriers of MC4R-rs17782313 compared to non-carriers.
Mc4r receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R-SphK1 (show SPHK1 Antibodies) signaling.
Our findings support the hypothesis that MC4R signaling in the pedunculopontine tegmental nucleus may involve in the modulation of midbrain dopamine systems.
These results indicate that intact CNS MC4R signaling is necessary for leptin (show LEP Antibodies) to exert its chronic antidiabetic, anorexic, and cardiovascular actions.
Mc4r signaling has a protective role in minimizing glucose fluctuations due to circadian rhythms and environmental light cues, a previously undiscovered connection between circadian biology and glucose metabolism mediated through the melanocortin system.
MC4R specifically inhibited the presynaptic N-type channel subtype, and this inhibition may be important for the effects of melanocortin in the central subdivision of the amygdala
Coupling of MC4R to Kir7.1 (show KCNJ13 Antibodies) may explain unusual aspects of the control of energy homeostasis by melanocortin signalling, including the gene dosage effect of MC4R and the sustained effects of AgRP (show AGRP Antibodies) on food intake.
The MC4R-expressing neurons regulating feeding are SIM1 (show SIM1 Antibodies)(+), located in the paraventricular hypothalamus, glutamatergic and not GABAergic, and do not express oxytocin, corticotropin-releasing hormone (show CRH Antibodies), vasopressin (show AVP Antibodies), or prodynorphin (show PDYN Antibodies).
These findings highlight an essential, and to our knowledge previously unknown, role for Ca(2 (show CA2 Antibodies)+) signaling in the MC4R pathway that leads to satiety, and a novel non-redundant role for NCKX4 (show Slc24a4 Antibodies)-mediated Ca(2 (show CA2 Antibodies)+) extrusion in controlling MC4R signaling
Posttranscriptional decrease of MC4R protein lowers the response to alpha-MSH in hypothalamic neurons exposed to even a mild level of lipid stress.
The MC4R gene may thus be a candidate gene for carcass traits with MC4R single nucleotide polymorphisms being potentially valuable as genetic markers for economic traits in Hanwoo.
The aim was to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits.
The results suggested that -129A>G and 1,069C>G single nucleotide polymorphism of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.
results are suggestive that adrenal glucocorticoid production could be regulated through melanocortin 4 receptor
Single nucleotide polymorphisms in 5'-untranslated region of MC4R gene, were detected.
These results indicate that genetic selection against boar taint is possible using MC4R as a marker.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of MC4R agonist [Nle(4), d-Phe(7)]-alpha-melanocyte stimulating hormone (show POMC Antibodies) in pigs homozygous for the missense mutation in the MC4R.
study did not find any significant associations for polymorphisms in insulin (show INS Antibodies)-like grwoth factor 2, GTP Binding Protein (show RND1 Antibodies) alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs
Linkage disequilibrium analysis among MC4R, LEP (show LEP Antibodies) and H-FABP (show FABP3 Antibodies) revealed that these genes were independent.
The c.1426G>A polymorphism affects daily gain, feed conversion ratio and ham (show ATF7IP Antibodies) weight in both breeds, lean cuts in the Italian Duroc and backfat thickness in the Italian Large White.
MC4R allelic variants had no effects on meat quality traits.
The effects of missense mutations of MC4R on carcass composition, growth traits and meat quality in 1191 gilts of five swine breeds are reported.
No effect of the MC4R trait nucleotides could be seen on muscle growth.
Results of associated analysis show that the polymorphism of MC4R gene was associated traits of back fat thickness (BF).
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
melanocortin receptor 4
, melanocortin 4-receptor
, melanocortin 4 receptor
, melanocortin-4 receptor
, Melanocortin receptor 4