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anti-Melanocortin 4 Receptor (MC4R) Antibodies

The protein encoded by MC4R is a membrane-bound receptor and member of the melanocortin receptor family. Additionally we are shipping Melanocortin 4 Receptor Kits (10) and Melanocortin 4 Receptor Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MC4R 4160 P32245
MC4R 17202 P56450
MC4R 25635 P70596
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Top anti-Melanocortin 4 Receptor Antibodies at

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of MC4R in human brain tissue with this product a... Western blot analysis of MC4R in rat brain tissue lysate with this pro... 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ICC, IHC, WB Western blot analysis of rat brain lysates: 1. Anti-Melanocortin Recep... Western blot analysis of mouse brain lysates: 1. Anti-Melanocortin Rec... 50 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, IHC (p) Staing of Human Brain paraffin sections using SP4387 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from MCF-7 cells, using MC4R Antibod... 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IHC (p) Anti-MC4 Receptor antibody  ABIN1049046 IHC staining of human brain. I... 50 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IHC (p) Human, Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of MC4 Receptor staining in human brain f... Western blot analysis of MC4 Receptor expression in EOC20 (A) whole ce... 200 μL Log in to see 9 Days
Horse Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days

MC4R Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , , , ,

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Top referenced anti-Melanocortin 4 Receptor Antibodies

  1. Human Polyclonal MC4R Primary Antibody for EIA, IHC (p) - ABIN500250 : Gantz, Miwa, Konda, Shimoto, Tashiro, Watson, DelValle, Yamada: Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. in The Journal of biological chemistry 1993 (PubMed)

  2. Human Polyclonal MC4R Primary Antibody for ICC, IHC - ABIN1742042 : Gantz, Fong: The melanocortin system. in American journal of physiology. Endocrinology and metabolism 2003 (PubMed)

More Antibodies against Melanocortin 4 Receptor Interaction Partners

Zebrafish Melanocortin 4 Receptor (MC4R) interaction partners

  1. MRAP2b decreases the constitutive activity of the MC4R during fasting periods, driving the animal toward a positive energy balance.

  2. MRAP2 proteins allow for developmental control of MC4R activity, with MRAP2a blocking its function and stimulating growth during larval development, whereas MRAP2b enhances responsiveness to alpha-MSH once the zebrafish begins feeding, thus increasing the capacity for regulated feeding and growth.

Human Melanocortin 4 Receptor (MC4R) interaction partners

  1. Uncontrolled eating scores were higher in C-allele carriers of MC4R-rs17782313 compared to non-carriers.

  2. Data show that co-expression with MRAPalpha, but not MRAP2, enhances MC4R constitutive activity. MRAPalpha-enhanced MC4R constitutive activity is not dependent on MC4R complex glycosylation but may result from MRAPalpha-induced changes in MC4R conformational states.

  3. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis--{REVIEW}

  4. MC4R (melanocortin-4 receptor) rs17782313 gene polymorphism is associated with higher triglyceride levels in older Chinese women

  5. The variant rs17782313 OF mc4r is associated with an increased risk of hypertriglyceridemia in obese children and adolescents

  6. Obese children carrying the FTO (show FTO Antibodies) GG and/or the MC4R CC genotype lost more body weight in comparison to non-carriers from a lifestyle intervention.

  7. The interaction between FTO (show FTO Antibodies) and MC4R polymorphisms is associated with the development of PCOS.

  8. The age of obesity onset in the present child generation of MC4R mutation carriers is decreasing compared to the age of onset in their parents' generation.

  9. FTO (show FTO Antibodies) homozygotes and FTO (show FTO Antibodies) heterozygotes correspond to 18.0% and 45.9% of neonates, respectively. MC4R homozygotes and MC4R heterozygotes were identified in 6.7% and 36.3% of neonates, respectively

  10. There is a synergistic effect of the high-risk alleles of the FTO (show FTO Antibodies) and MC4R genes on the obese

Mouse (Murine) Melanocortin 4 Receptor (MC4R) interaction partners

  1. Mc4r receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling.

  2. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R-SphK1 (show SPHK1 Antibodies) signaling.

  3. Our findings support the hypothesis that MC4R signaling in the pedunculopontine tegmental nucleus may involve in the modulation of midbrain dopamine systems.

  4. These results indicate that intact CNS MC4R signaling is necessary for leptin (show LEP Antibodies) to exert its chronic antidiabetic, anorexic, and cardiovascular actions.

  5. Mc4r signaling has a protective role in minimizing glucose fluctuations due to circadian rhythms and environmental light cues, a previously undiscovered connection between circadian biology and glucose metabolism mediated through the melanocortin system.

  6. MC4R specifically inhibited the presynaptic N-type channel subtype, and this inhibition may be important for the effects of melanocortin in the central subdivision of the amygdala

  7. Coupling of MC4R to Kir7.1 (show KCNJ13 Antibodies) may explain unusual aspects of the control of energy homeostasis by melanocortin signalling, including the gene dosage effect of MC4R and the sustained effects of AgRP (show AGRP Antibodies) on food intake.

  8. The MC4R-expressing neurons regulating feeding are SIM1 (show SIM1 Antibodies)(+), located in the paraventricular hypothalamus, glutamatergic and not GABAergic, and do not express oxytocin, corticotropin-releasing hormone (show CRH Antibodies), vasopressin (show AVP Antibodies), or prodynorphin (show PDYN Antibodies).

  9. These findings highlight an essential, and to our knowledge previously unknown, role for Ca(2 (show CA2 Antibodies)+) signaling in the MC4R pathway that leads to satiety, and a novel non-redundant role for NCKX4 (show Slc24a4 Antibodies)-mediated Ca(2 (show CA2 Antibodies)+) extrusion in controlling MC4R signaling

  10. Posttranscriptional decrease of MC4R protein lowers the response to alpha-MSH in hypothalamic neurons exposed to even a mild level of lipid stress.

Cow (Bovine) Melanocortin 4 Receptor (MC4R) interaction partners

  1. The MC4R gene may thus be a candidate gene for carcass traits with MC4R single nucleotide polymorphisms being potentially valuable as genetic markers for economic traits in Hanwoo.

  2. The aim was to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits.

  3. The results suggested that -129A>G and 1,069C>G single nucleotide polymorphism of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.

  4. results are suggestive that adrenal glucocorticoid production could be regulated through melanocortin 4 receptor

  5. Single nucleotide polymorphisms in 5'-untranslated region of MC4R gene, were detected.

Pig (Porcine) Melanocortin 4 Receptor (MC4R) interaction partners

  1. These results indicate that genetic selection against boar taint is possible using MC4R as a marker.

  2. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  3. Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of MC4R agonist [Nle(4), d-Phe(7)]-alpha-melanocyte stimulating hormone (show POMC Antibodies) in pigs homozygous for the missense mutation in the MC4R.

  4. study did not find any significant associations for polymorphisms in insulin (show INS Antibodies)-like grwoth factor 2, GTP Binding Protein (show RND1 Antibodies) alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs

  5. Linkage disequilibrium analysis among MC4R, LEP (show LEP Antibodies) and H-FABP (show FABP3 Antibodies) revealed that these genes were independent.

  6. The c.1426G>A polymorphism affects daily gain, feed conversion ratio and ham (show ATF7IP Antibodies) weight in both breeds, lean cuts in the Italian Duroc and backfat thickness in the Italian Large White.

  7. MC4R allelic variants had no effects on meat quality traits.

  8. The effects of missense mutations of MC4R on carcass composition, growth traits and meat quality in 1191 gilts of five swine breeds are reported.

  9. No effect of the MC4R trait nucleotides could be seen on muscle growth.

  10. Results of associated analysis show that the polymorphism of MC4R gene was associated traits of back fat thickness (BF).

Melanocortin 4 Receptor (MC4R) Antigen Profile

Protein Summary

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.

Gene names and symbols associated with MC4R

  • melanocortin 4 receptor (mc4r) antibody
  • melanocortin 4 receptor (MC4R) antibody
  • melanocortin 4 receptor (LOC100218148) antibody
  • melanocortin 4 receptor (Mc4r) antibody
  • LOC100218148 antibody
  • Mc4-r antibody
  • MC4R antibody
  • si:dkey-151m6.62 antibody
  • zMC4 antibody

Protein level used designations for MC4R

melanocortin receptor 4 , melanocortin 4-receptor , melanocortin 4 receptor , melanocortin-4 receptor , Melanocortin receptor 4 , MC4-R

286833 Danio rerio
428485 Gallus gallus
445900 Takifugu rubripes
468556 Pan troglodytes
483961 Canis lupus familiaris
698596 Macaca mulatta
100016168 Monodelphis domestica
100147707 Ovis aries
100218148 Taeniopygia guttata
100379598 Cavia porcellus
4160 Homo sapiens
17202 Mus musculus
25635 Rattus norvegicus
281300 Bos taurus
397359 Sus scrofa
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