Mesoderm Specific Transcript Proteins (MEST)

MEST encodes a member of the alpha/beta hydrolase superfamily. Additionally we are shipping MEST Antibodies (26) and MEST Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MEST 17294 Q07646
Rat MEST MEST 58827 Q6P5P5
MEST 4232 Q5EB52
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Top MEST Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

MEST Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Mesoderm Specific Transcript (MEST) Interaction Partners

Mouse (Murine) Mesoderm Specific Transcript (MEST) interaction partners

  1. The androgenetic patterns of H19, Snrpn, and Mest were maintained even after differentiation of germline-derived pluripotent stem cells(gPS) into neural stem cells(NSC), whereas the fully unmethylated status of Ndn in SSCs was altered to somatic patterns in gPS cells and gPS-NSCs.

  2. The balance of factors controlling fat deposition can be evaluated in part by the differential expression profiles of Mest and Sfrp5 (show SFRP5 Proteins) genes with functions linked to fat deposition as long as there is an active accumulation of fat mass.

  3. the expression of Mest and Sfrp5 (show SFRP5 Proteins) were tightly associated across the 5 mouse strains with the highest and lowest expression occurring in DBA (show RPS19 Proteins)/2J and C57BL/6J (B6) respectively suggesting a common mechanism for their regulation.

  4. Although both Mest and miR (show MLXIP Proteins)-335 are highly expressed during muscle development and regeneration, only Mest+/- (maternal/paternal) mice show retardation of body growth.

  5. The paternally expressed imprinted gene Mest was only detected in haploid androgenetic blastocysts and was significantly lower in this group relative to the controls, indicating that the gene maintains expression patterns specific to its parental origin.

  6. analysis of modifications of H3 histone (show HIST1H3B Proteins) in H19 (show NCKAP1 Proteins) and MEST imprinted genes in blastocysts produced in vitro from non-vitrified and vitrified two-cell embryos

  7. Results suggest that at least one allele of Mest expression is required in the somatic tissues of adult individuals and that under certain conditions (such as in the presence of a Mest insertional mutation or in an altered genetic background), somatically acquired alterations of allelic expression at the Mest locus may occur.

  8. The data showed that Mest expression was regulated through cAMP-dependent protein kinase A pathways during differentiation of preadipocytes into adipocytes in vitro, supporting the critical role of Mest in proliferation and differentiation of adipocytes.

  9. The identification of new imprinted RNA products at the Mest locus, longer variants of the RNA, called MestXL, transcribed >10 kb into the downstream antisense gene Copg2 (show COPG2 Proteins).

  10. Mest/Peg1 is a novel down-regulator of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling during adipogenic differentiation.

Human Mesoderm Specific Transcript (MEST) interaction partners

  1. G4 formation at motifs not previously identified through bioinformatic analysis of the MEST promoter, is reported.

  2. altered DNA methylation (show HELLS Proteins) at imprinted domains including IGF2/H19 (show NCKAP1 Proteins) and PEG1/MEST may mediate the association between human papillomavirus infection and invasive cervical cancer

  3. The expression levels of miR (show MLXIP Proteins)-335 significantly correlated with those of MEST, supporting the notion that the intronic miR (show MLXIP Proteins)-335 is co-expressed with its host gene

  4. DNA methylation (show HELLS Proteins) level at the H19 (show NCKAP1 Proteins) and MEST differentially methylated regions (DMRs)is reduced in placentas from pregnancies conceived by IVF (show SCN5A Proteins)/ICSI when compared with placentas from spontaneous conception.

  5. Paternal methylation aberrations at imprinting control regions of DLK1 (show DLK1 Proteins)-GTL2, MEST (PEG1), and ZAC (PLAGL1 (show PLAGL1 Proteins)) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages.

  6. Data indicate that ARMCX2 (show ARMCX2 Proteins), COL1A1 (show COL1A1 Proteins), MDK (show MDK Proteins), MEST and MLH1 (show MLH1 Proteins) genes acquired methylation in drug-resistant ovarian cancer-sustaining (side population) cells.

  7. MEST showed tissue-specific imprinting, being paternally expressed in skeletal muscle, fat, pituitary gland, heart, kidney, lung, stomach and uterus, and maternally expressed in spleen and liver.

  8. In cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes.

  9. Regardless of conception method, the PEG1 methylation percentage in chorionic villus from spontaneous abortions is significantly higher than in villus from induced abortions and multifetal reduction.

  10. data demonstrated that tumorigenesis of leiomyoma is associated with overexpression of isoform 1 of PEG1/MEST gene, but not with loss of imprinting of the gene

MEST Protein Profile

Protein Summary

This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15.

Gene names and symbols associated with MEST

  • mesoderm specific transcript (Mest)
  • mesoderm specific transcript (MEST)
  • mesoderm specific transcript homolog (mouse) (MEST)
  • AA408879 protein
  • AI256745 protein
  • PEG1 protein

Protein level used designations for MEST

mesoderm-specific transcript protein , paternally-expressed gene 1 protein , mesoderm specific transcript homolog , mesoderm-specific transcript homolog protein

17294 Mus musculus
58827 Rattus norvegicus
4232 Homo sapiens
607717 Canis lupus familiaris
404180 Bos taurus
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