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human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis. Additionally we are shipping Metadherin Proteins (8) and Metadherin Kits (7) and many more products for this protein.
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Human Polyclonal MTDH Primary Antibody for IF (p), IHC (p) - ABIN678863
Guo, Zhang, Liu, Wang, Liu, Wang, Ma, Wu: Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis. in Journal of pediatric urology 2014
Show all 4 references for ABIN678863
Human Monoclonal MTDH Primary Antibody for FACS, IHC - ABIN969496
Britt, Yang, Yang, Flanagan, Callanan, Lim, Lin, Hixson: Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. in Experimental cell research 2004
Show all 2 references for ABIN969496
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Antibodies) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Antibodies)/AEG-1/c-Myc (show MYC Antibodies) mice that was not observed when either AEG-1 or c-Myc (show MYC Antibodies) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B Antibodies)- or TNF-alpha (show TNF Antibodies)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Antibodies).
oncogene (show RAB1A Antibodies) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF Antibodies) superfamily member TRAIL (Tumor Necrosis Factor (show TNF Antibodies)-related Apoptosis-inducing Ligand) in breast cancer
The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2 (show AKR1C2 Antibodies).
Data showed that AEG1 and MMP7 (show MMP7 Antibodies) levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK (show MAPK1 Antibodies)-p42/p44 (show PSMC6 Antibodies)-dependent activation of MMP7 (show MMP7 Antibodies).
Results indicate that microRNA miR (show MLXIP Antibodies)-497 directly inhibited the 3'-untranslated regions (3' UTRs) of vascular endothelial growth factor A (VEGFA (show VEGFA Antibodies)) and astrocyte elevated gene-1 (AEG-1).
High AEG-1 staining index might be associated with tumor progression and poor survival status in patients with gastrointestinal cancer. Meta-analysis.
miR (show MLXIP Antibodies)-302c-3p play a pivotal role in the progression of glioma by targeting MTDH and is a potential inhibitor in glioma treatment.
Identify two novel factors, AKR1C2 (show AKR1C2 Antibodies) (positive factor) and NF1 (show NF1 Antibodies) (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer.
Knockdown of MTDH inhibits phosphorylation of AKT (show AKT1 Antibodies) and increased apoptosis related protein expression.
EFEMP1 (show FBLN3 Antibodies) might indirectly enhance the expression of MMP-2 (show MMP2 Antibodies), providing a potential explanation for the role of AEG-1 in metastasis. NF-kappaB (show NFKB1 Antibodies) pathways might be one of the effective ways which EFEMP1 (show FBLN3 Antibodies) was induced by AEG-1.
AEG-1 mediates CCL3 (show CCL3 Antibodies)/CCR5 (show CCR5 Antibodies)-induced EMT (show ITK Antibodies) development via both Erk1/2 (show MAPK1/3 Antibodies) and Akt (show AKT1 Antibodies) signaling pathway in CM patients, which indicates CCL3 (show CCL3 Antibodies)/CCR5 (show CCR5 Antibodies)-AEG-1-EMT (show ITK Antibodies) pathway could be suggested as a useful target to affect the progression of CM.
Data established that AEG-1 is frequently upregulated and functions as an oncogene (show RAB1A Antibodies) by regulating several major signaling pathways in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) suggesting potential role as a biomarker or target for HCC (show FAM126A Antibodies) therapy. [review]
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein