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human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis. Additionally we are shipping Metadherin Proteins (8) and Metadherin Kits (7) and many more products for this protein.
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Human Polyclonal MTDH Primary Antibody for IF (p), IHC (p) - ABIN678863
Guo, Zhang, Liu, Wang, Liu, Wang, Ma, Wu: Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis. in Journal of pediatric urology 2014
Show all 4 references for ABIN678863
Human Monoclonal MTDH Primary Antibody for FACS, IHC - ABIN969496
Britt, Yang, Yang, Flanagan, Callanan, Lim, Lin, Hixson: Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. in Experimental cell research 2004
Show all 2 references for ABIN969496
Human Polyclonal MTDH Primary Antibody for ICC, IF - ABIN4332035
Nohata, Hanazawa, Kikkawa, Mutallip, Sakurai, Fujimura, Kawakami, Chiyomaru, Yoshino, Enokida, Nakagawa, Okamoto, Seki: Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). in Journal of human genetics 2011
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Human Monoclonal MTDH Primary Antibody for ELISA, FACS - ABIN4332034
Wang, Lim, Shi, Lee, Deng, Xie, Zhu, Wang, Pocalyko, Yang, Rejto, Mao, Park, Xu: Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2013
Show all 2 references for ABIN4332034
Human Polyclonal MTDH Primary Antibody for ICC, IF - ABIN4332036
Liu, Wu, Peng: Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling. in Oncology letters 2013
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Antibodies) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Antibodies)/AEG-1/c-Myc (show MYC Antibodies) mice that was not observed when either AEG-1 or c-Myc (show MYC Antibodies) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B Antibodies)- or TNF-alpha (show TNF Antibodies)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Antibodies).
oncogene (show RAB1A Antibodies) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF Antibodies) superfamily member TRAIL (Tumor Necrosis Factor (show TNF Antibodies)-related Apoptosis-inducing Ligand) in breast cancer
The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.
Our results suggest that underexpression of miR (show MLXIP Antibodies)-30a-5p might function as a tumor suppressing miRNA by directly targeting MTDH in HCC (show FAM126A Antibodies) and is therefore a potential candidate biomarker for HCC (show FAM126A Antibodies) targeting therapy.
MiR (show MLXIP Antibodies)-136 plays a key role in temozolomide (TMZ) resistance by targeting AEG-1 in glioma cell line, suggesting that miR (show MLXIP Antibodies)-136 can be used to predict a patient's response to TMZ therapy as well as serve as a novel potential maker for glioma therapy.
Data indicate metadherin (MTDH) as a direct target gene of microRNA miR (show MLXIP Antibodies)-630.
AEG-1 overexpression is closely associated with epithelial-mesenchymal transition and promote metastasis in tongue squamous cell carcinoma.
MiR (show MLXIP Antibodies)-30a-5p may play an essential role in the cell growth and apoptosis of hepatocellular carcinoma cells, partially via targeting AEG-1.
Suggest that miR (show MLXIP Antibodies)-377 plays an important role in the development of NSCLC by regulating AEG-1 expression.
High MTDH expression is associated with multiple myeloma.
In patients with non-small cell lung cancer, AEG-1 expression was an independent prognostic factor for both overall and disease-free survival.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2 (show AKR1C2 Antibodies).
Data showed that AEG1 and MMP7 (show MMP7 Antibodies) levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK (show MAPK1 Antibodies)-p42/p44 (show PSMC6 Antibodies)-dependent activation of MMP7 (show MMP7 Antibodies).
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein