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Myocilin Proteins (MYOC)

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. Additionally we are shipping Myocilin Antibodies (58) and Myocilin Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYOC 17926 O70624
MYOC 4653 Q99972
MYOC 81523 Q9R1J4
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Top Myocilin Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$341.00
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$679.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
$618.75
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$3,309.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,327.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,331.17
Details

MYOC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , , , , ,
,
Rat (Rattus) ,

Top referenced Myocilin Proteins

  1. Human MYOC Protein expressed in Human Cells - ABIN2005424 : Kubota, Noda, Wang, Minoshima, Asakawa, Kudoh, Mashima, Oguchi, Shimizu: A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping. in Genomics 1997 (PubMed)
    Show all 5 references for ABIN2005424

  2. Human MYOC Protein expressed in HEK-293 Cells - ABIN2181527 : Kwon, Fingert, Kuehn, Alward: Primary open-angle glaucoma. in The New England journal of medicine 2009 (PubMed)

More Proteins for Myocilin (MYOC) Interaction Partners

Mouse (Murine) Myocilin (MYOC) interaction partners

  1. Mutated myocilin and heterozygous Sod2 (show SOD2 Proteins) deficiency act synergistically in a mouse model of open-angle glaucoma

  2. myocilin promotes cell proliferation and resistance to apoptosis via the ERK1/2 MAPK (show MAPK1 Proteins) signaling pathway.

  3. Myocilin binds to ErbB2 (show ERBB2 Proteins)/ErbB3 (show ERBB3 Proteins), activates these receptors, and affects the downstream PI3K-AKT (show AKT1 Proteins) signaling pathway

  4. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38 (show CRK Proteins), Erk1/2, and JNK (show MAPK8 Proteins) MAP kinase (show MAPK1 Proteins) signaling pathways

  5. We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of dystrophin (show DMD Proteins) associated protein complex.

  6. The TIGR is implicated in resistance to oxidative stress. Despite the presence of a SOD motif, which is necessary for protection in mammalian cells, the protein is not a functional SOD, but might be involved in SOD activity.

  7. TIGR is a newly identified component of the CNS glial scar that is likely to contribute to neuronal regenerative failure characteristic of the mammalian CNS.

  8. Results do not support a causative role for increased MYOC levels or the MYOC gene in steroid-induced glaucoma.

  9. Results show that myocilin and gamma-synuclein (show SNCG Proteins) interact and as a result, myocilin's properties are changed.

  10. These data suggest that production, apparent misfolding, and nonsecretion of mutant MYOC are not, by themselves, sufficient to cause glaucoma in vivo.

Human Myocilin (MYOC) interaction partners

  1. The rate of CYP1B1 (show CYP1B1 Proteins) mutations in Lebanese patients with primary congenital glaucoma (PCG) is lower than that reported in other Arab and Middle Eastern populations and suggests other genes are responsible.

  2. Data show that predictive genetic testing for early onset Myocilin glaucoma can facilitate early detection of disease or discharge from routine ophthalmic examinations.

  3. This study does not confirm a role for genetic variants in the MYOC, NR3C1 (show NR3C1 Proteins) and FKBP5 (show FKBP5 Proteins) genes in the pathogenesis of corticosteroid-induced ocular hypertension.

  4. Glaucomatous MYOC mutations activate the IL-1beta (show IL1B Proteins)/NF-kappaB (show NFKB1 Proteins) inflammatory stress response and the glaucoma marker SELE (show SELE Proteins) in trabecular meshwork cells.

  5. Secondary structure prediction of the Ser341Pro MYOC gene mutation suggested that the MYOC protein was misfolded.

  6. Mutations in myoc ofactomedin domain are causative in the autosomal dominant inherited form of the prevalent ocular disorder glaucoma.

  7. A novel heterozygous missense mutation c.761CMYOC gene was identified as being co-segregated with the primary open-angle glaucoma phenotype in this family.

  8. All POAG samples underwent full sequencing of the MYOC gene, and we found a sensitivity of 100%, specificity of 99.91%, positive predictive value of 95.65%, and negative predictive value of 100% between imputation and sequencing.

  9. FAs (show FAS Proteins), expression of fibrogenic markers, and myocilin in HTM cells. These characteristics of Hic-5 (show TGFB1I1 Proteins) in TM cells indicate its importance in regulation of AH outflow through the TM in both normal and glaucomatous eyes.

  10. Haplotype analysis of association of the MYOC gene with primary angle-closure glaucoma in a Han Chinese population

Cow (Bovine) Myocilin (MYOC) interaction partners

  1. endoproteolytic processing might regulate the activity of myocilin; the inhibition of the processing by pathogenic mutations impairs the normal role of myocilin

Myocilin (MYOC) Protein Profile

Protein Summary

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

Gene names and symbols associated with Myocilin Proteins (MYOC)

  • myocilin (MYOC)
  • myocilin (myoc)
  • myocilin (Myoc)
  • myocilin, trabecular meshwork inducible glucocorticoid response (MYOC)
  • myocilin, trabecular meshwork inducible glucocorticoid response (Myoc)
  • AI957332 protein
  • GLC1A protein
  • GPOA protein
  • JOAG protein
  • JOAG1 protein
  • MGC136645 protein
  • MYOC protein
  • myocilin protein
  • Tigr protein
  • zgc:136645 protein

Protein level used designations for Myocilin Proteins (MYOC)

myocilin , trabecular meshwork-induced glucocorticoid response protein , mutated trabecular meshwork-induced glucocorticoid response protein

GENE ID SPECIES
397046 Sus scrofa
548602 Danio rerio
704406 Macaca mulatta
17926 Mus musculus
4653 Homo sapiens
81523 Rattus norvegicus
281342 Bos taurus
101087632 Felis catus
490344 Canis lupus familiaris
100008897 Oryctolagus cuniculus
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