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Myostatin Proteins (MSTN)

The protein encoded by MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping Myostatin Antibodies (205) and Myostatin Kits (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MSTN 2660 O14793
MSTN 17700 O08689
Rat MSTN MSTN 29152 O35312
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Top Myostatin Proteins at

Showing 10 out of 73 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Nicotiana benthamiana Human His tag SDS-PAGE analysis of recombinant Myostatin. Samples were loaded in 15 ... Immune-detection with specific anti-human Myostatin IgG by WB Western ... 100 μg Log in to see 6 to 7 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 4 to 6 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
HOST_Human Cells Mouse Fc Tag 10 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 7 to 9 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 3 to 4 Days

MSTN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
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Mouse (Murine) , , ,
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Rat (Rattus) , ,

More Proteins for Myostatin (MSTN) Interaction Partners

Zebrafish Myostatin (MSTN) interaction partners

  1. improving muscle growth in a fish species by mixing a classical strategy, such as compensatory growth, and a biotechnological approach, such as the use of recombinant proteins for inhibiting the biological actions of MSTN(Myostatin)

  2. the expression of myostatin during development and the effects of its knock-down on various genes such as muscle regulatory transcription factors (MRFs), muscle-specific (show EIF3K Proteins) proteins (MSP (show MST1 Proteins)), and insulin (show INS Proteins)-like growth factors (IGFs).

  3. Epistatic analyses suggest a possible genetic interaction between Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis

Medaka Myostatin (MSTN) interaction partners

  1. Findings suggest that myostatin (MSTN) function is required for regulating the appropriate growth of skeletal muscle in medaka

Human Myostatin (MSTN) interaction partners

  1. Myostatin is a well-described negative regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes. It functions in the heart, skeletal muscle, and brain. Review.

  2. Plasma myostatin levels are increased in chronic obstructive pulmonary disease patients who have cor pulmonale.

  3. In human granulosa cells, GDF8 may play an important role in the modulation of cellular responsiveness to gonadotropins and in the regulation of ovarian steroid production, most likely as a luteinization inhibitor.

  4. Plasma myostatin might be suitable in predicting weight regain after marked weight loss, but no association with weight loss was observed in patients undergoing a non-surgical weight loss program.

  5. Plasma MSTN level was elevated in an early stage of CKD, which could be involved in the progression of sarcopenia.

  6. it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored.

  7. The aim of this study was to investigate MSTN polymorphisms in an elderly sarcopenic population in Turkey and determine how they relate to sarcopenia.

  8. There is a significant decrease in levels of circulating myostatin in postsurgical acute phase reaction.

  9. Myostatin myocardial expression increases in the presence of structural cardiomyopathy either of hypertensive or other origin.

  10. In contrast to elite endurance and power track and field athletes, the MSTN 153RR genotype was not found in short distance-swimmers, and among the long distance-swimmers it was not associated with top level swimming performance.

Mouse (Murine) Myostatin (MSTN) interaction partners

  1. Agouti-related peptide (AgRP (show AGRP Proteins)) neuron activation acutely reprograms gene expression in BAT (show BAAT Proteins) toward a myogenic signature, including increased expression of myostatin. Interference with myostatin activity improves insulin (show INS Proteins) sensitivity that was impaired by AgRP (show AGRP Proteins) neurons activation.

  2. Increased expression of myostatin in heart muscle cells caused interstitial fibrosis via activation of the TAK-1 (show NR2C2 Proteins)-MKK3 (show MAP2K3 Proteins)/6-p38 (show CRK Proteins) signaling pathway

  3. study is the first to report an in vivo association between vitamin D, myostatin, and the regulation of muscle mass

  4. Report myostatin expression in early postnatal mouse masseter and rectus femoris muscles.

  5. An age-dependent decline in serum Gdf8 levels was identified.

  6. Mstn may negatively regulate Igf2 expression to control postnatal skeletal muscle growth, however differences in growth between male and female mice are not readily explained by changes in expression of Igf family members.

  7. the phenotypic and physiologic impact of postnatal myostatin inhibition on bite mechanics, were examined.

  8. Data (including data from studies in knockout mice) suggest that myostatin attenuation stimulates adipogenesis in vivo; reduced adiposity in mstn-/- knockout mice results from nutrient partitioning away from fat and in support of muscle.

  9. analysis of dual exon skipping of dystrophin (show DMD Proteins) and myostatin pre-mRNAs using phosphorodiamidate morpholino oligomers conjugated with an arginine-rich peptide

  10. Data show that circulating myostatin levels decreased with age and estimates of growth differentiation factor 11 (GDF11 (show GDF11 Proteins)) levels using myostatin null mice indicate that they were almost 500 times lower than those for myostatin.

Pig (Porcine) Myostatin (MSTN) interaction partners

  1. Single nucleotide polymorphisms in the MYOD1 (show MYOD1 Proteins) and GDF8 genes are associated with genetic transcription during myogenesis in pigs.

  2. The level of myostatin inversely correlated with miR (show MYLIP Proteins)-27a in fat and heart of pigs and also in proliferating porcine myoblasts. Overexpression of miR (show MYLIP Proteins)-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin.

  3. MSTN g.435G>A and g.447A>G affected carcass traits in pigs

  4. The genotypes of MSTN g.435G > A and g.447A > G SNPs in Duroc pigs were studied. The 435GG/447AA (show COL16A1 Proteins) individually had significantly higher average daily gain, body weight at 70 d and 150 d , and a lower age at 110 kg than 435AA/447GG individuals.

  5. Porcine MSTN could be upregulated by isobutyl-1-methylxanthine , MyoD (show MYOD1 Proteins), and PPARgamma (show PPARG Proteins) but downregulated by C/EBPalpha (show CEBPA Proteins) and C/EBPbeta (show CEBPB Proteins).

  6. a vital enhancer region was identified between nucleotides -218 and -137 in promoter region of porcine myostatin

  7. It was concluded that myostatin is a factor broadly expressed in the internal organs and muscle tissues of pigs.

  8. In this study, haplotypes involving 3 polymorphic sites in the promoter region of the porcine myostatin gene were identified and their effect on production traits, gene expression as well as on skeletal muscle traits were analysed.

  9. In both skeletal muscle and heart muscle growth, the insulin-like growth factor-2 (show IGF2 Proteins):myostatin interaction seems to play an important role.

  10. A comparative analysis of the pig BAC sequence involved in the regulation of MSTN was performed.

Cow (Bovine) Myostatin (MSTN) interaction partners

  1. Data indicate that the the promoter trap vector PIII-myostatin could knock out the bovine myostatin gene.

  2. The effects of myostatin and myogenic factor 5 (show MYF5 Proteins) polymorphisms on growth and muscle traits of Marchigiana breed were assessed.

  3. we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene.

  4. proof-of-concept study is the first to produce MSTN mutations in cattle, and may allow the development of genetically modified strains of double-muscled cattle.

  5. Mutations in the leader peptide of the bovine myostatin gene effectively promote the proliferation of bovine fibroblast cells.

  6. there were 18 SNPs identified in the Qinchuan cattle promoter region compared with those of other cattle compared to the Red Angus cattle myostatin promoter region.

  7. A 3-way interaction of myostatin genotype (MG), season, and trigonometric function periodicities of 24 h and 12 h indicate that a genotype x environment interaction exists for MG.

  8. These results show for the first time that myostatin regulates the differential expression of chemokines in skeletal muscle cells.

  9. bovine myostatin is a specific target of miR (show MYLIP Proteins)-27b and that miRNAs contribute to explain additive phenotypic hypertrophy in Piedmontese cattle selected for the MSTN gene mutation

  10. Mutations in the myostatin gene, responsible for the double muscling condition in cattle, were targeted to estimate the time since the most recent common ancestor. Each myostatin allele had a recent common ancestor (<400 years ago).

Goat Myostatin (MSTN) interaction partners

  1. The reduced expression of myostatin gene was achieved and measured in clonal fibroblast cells by real-time PCR.

  2. This study also suggests the importance of siRNA-mediated knockdown of MSTN as a potential alternative to increase muscle mass and meat production.

  3. A study of the MSTN 5' upstream region and investigation of 5'UTR TTTTA deletion was carried out in seven different Indian goat breeds. An 1181 bp fragment of 5' upstream region of MSTN gene was PCR amplified, cloned, and sequenced.

  4. myostatin plays a negative role in regulating the expression of adipogenesis related genes in goat fetal fibroblasts.

  5. Polymorphisms of myostatin gene as markers associated with growth in Boer goats.

Horse (Equine) Myostatin (MSTN) interaction partners

  1. The effect of an Equine Repetitive Element 1 insertion in the promoter of the myostatin gene, which is involved in muscle development, was also investigated.

  2. Myostatin mRNA but not protein was increased in skeletal muscle of obese compared with lean animals. Myostatin mRNA was increased in crest fat of obese animals and protein was undetectable. Serum myostatin was higher in obese than lean animals.

  3. The tissue-specific presence of myostatin, the moystatin receptor (activin receptor IIB (show ACVR2B Proteins), ActRIIB (show ACVR2B Proteins)), follistatin (show FST Proteins) and perilipin (show PLIN1 Proteins), genes and proteins across a range of equine tissues, were examined.

  4. The candidate for racing performance genomic region contained eight genes annotated by ENSEMBL, including the myostatin gene (MSTN).

  5. Polymorphisms of the MSTN promoter region in 5 horse breeds in Poland are reported.

  6. significant association observed between genotype and mRNA abundance for untrained horses with the C/C cohort having highest MSTN mRNA levels,T/T group lowest levels and C/T group intermediate levels; following training there was significant decrease in MSTN mRNA which was most apparent for the C/C cohort

  7. Exon 2 of the MSTN gene, which encodes part of the TGF-beta (show TGFB1 Proteins) pro-peptide, was sequenced in 332 horses of 20 different breeds and compared with the horse MSTN gene sequence deposited in GenBank. The sequences obtained revealed the presence of 11 haplotypes represented by 10 variable nucleotide mutations, eight of them corresponding to amino acid sequence changes.

  8. Variation at the MSTN gene influences speed in Thoroughbred horses.

  9. This study demonstrates that the g.66493737C>T single nucleotide polymorphism in MSTN provides the most powerful genetic marker for prediction of race distance aptitude in Thoroughbreds.

  10. Characterized the horse (Equus caballus) MSTN gene and identified and analysed single nucleotide polymorphisms (SNPs) in breeds of different morphological types.

Rabbit Myostatin (MSTN) interaction partners

  1. Alignment of sequence data with the GenBank sequence of the rabbit MSTN gene identified three single nucleotide polymorphisms (SNPs). Significant linkage was found between the novel SNP c.373+234G>A and nine carcass composition traits.

  2. These results suggest that the mutations in the upstream regulatory region of the MSTN gene are beneficial to the rabbit soma development, and the mutations can be used as molecular markers for the selection of the meat quality of rabbits.

  3. Studied and compared mRNA levels of myostatin (MSTN), myogenin (MyoG (show MYOG Proteins)), and myosin heavy chain (MyHC) in skeletal muscles of two rabbit breeds with different body sizes and growth rates.

  4. indicated that MSTN is not an important source of variability for performance traits, at least in the rabbit population

Myostatin (MSTN) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

Gene names and symbols associated with Myostatin Proteins (MSTN)

  • myostatin (MSTN)
  • myostatin b (mstnb)
  • myostatin (AaeL_AAEL003224)
  • myostatin (BRAFLDRAFT_290840)
  • myostatin (Mstn)
  • myostatin (mstn)
  • myostatin (LOC100125998)
  • Cmpt protein
  • GDF-8 protein
  • Gdf8 protein
  • MSLHP protein
  • mstn protein
  • NV13143 protein
  • zgc:109749 protein

Protein level used designations for Myostatin Proteins (MSTN)

Growth/differentiation factor 8 , growth/differentiation factor-8 , GDF-8 , growth differentiation factor 8 , growth/differentiation factor 8 , mstn-1 , myostatin-1 , myostatin-B , zfMSTN-1 , myostatin , compact

100303659 Meleagris gallopavo
798441 Danio rerio
5577632 Aedes aegypti
7221321 Branchiostoma floridae
100118233 Nasonia vitripennis
100379652 Ictalurus punctatus
100529165 Oryzias latipes
2660 Homo sapiens
17700 Mus musculus
29152 Rattus norvegicus
373964 Gallus gallus
399534 Sus scrofa
281187 Bos taurus
403433 Canis lupus familiaris
100860887 Capra hircus
100033832 Equus caballus
443449 Ovis aries
100735599 Cavia porcellus
100125998 Oryctolagus cuniculus
710114 Macaca mulatta
100968757 Pan paniscus
470605 Pan troglodytes
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