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Myxovirus (Influenza Virus) Resistance 2 (Mouse) Proteins (MX2)

The protein encoded by MX2 has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. Additionally we are shipping MX2 Antibodies (13) and MX2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MX2 17858 Q9WVP9
MX2 286918  
MX2 4600 P20592
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MX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,

More Proteins for Myxovirus (Influenza Virus) Resistance 2 (Mouse) (MX2) Interaction Partners

Mouse (Murine) Myxovirus (Influenza Virus) Resistance 2 (Mouse) (MX2) interaction partners

  1. The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized.

Human Myxovirus (Influenza Virus) Resistance 2 (Mouse) (MX2) interaction partners

  1. These experiments suggested that MxB does not contribute to the HIV-1 restriction observed in IFN-alpha (show IFNA Proteins)-treated human cells.

  2. Together, the data demonstrate that interferon-beta inhibits foamy virus early in infection and that MxB is not a restriction factor of foamy virus.

  3. We propose that lower-order oligomerization of MX2 is sufficient for the effective inhibition of human immunodeficiency virus type 1.

  4. Study analyzed the evolutionary history of MX2 at the inter- and intraspecific level and use this information to identify a haplotype that associates with natural resistance to HIV-1 infection in humans; the ancestral (G) allele of rs2074560 protects from HIV-1 infection with a recessive effect.

  5. The high prevalence of MxB-resistant mutations in the CypA-binding loop indicates the significant selective pressure of MxB on HIV-1 replication in vivo.

  6. MxB inhibits HIV-1 by interfering with minimally two steps of infection, nuclear entry and post-nuclear trafficking and/or integration, without destabilizing the inherent catalytic activity of viral preintegration complexes.

  7. HIV-seronegative women who use Depo-Provera have the highest levels of Mx2 expression, highlighting a possible mechanism for hormonal modulation of HIV resistance.

  8. The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized.

  9. MxB oligomerization is important for the ability of MxB to bind to the HIV-1 core proteins.

  10. A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2.

Cow (Bovine) Myxovirus (Influenza Virus) Resistance 2 (Mouse) (MX2) interaction partners

  1. Data indicate that the expression profiles of ISG15 (show ISG15 Proteins), MX1 (show MX1 Proteins), MX2, and OAS1 (show OAS1 Proteins) could be a useful diagnostic biomarker of gestation.

Pig (Porcine) Myxovirus (Influenza Virus) Resistance 2 (Mouse) (MX2) interaction partners

  1. A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus.

  2. Expression of Mx protein and interferon-alpha (IFN-alpha (show IFNA Proteins)) was examined by immunohistochemistry in pigs experimentally infected with swine influenza virus.

  3. The porcine Mx1 (show MX1 Proteins) gene and promoter share the major structural and functional characteristics displayed by their homologs described in cattle, mouse, chicken, and man.

  4. The 341-bp MX2 promoter region contained regulatory sequences for ISRE, GC box, Sp1 (show SP1 Proteins) and AP-1 (show JUN Proteins), as well as a TATA box. Nucleotide sequences of the MX2 promoter region revealed four substitutions and one deletion, in which six genotypes were classified.

MX2 Protein Profile

Protein Summary

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.

Gene names and symbols associated with MX2

  • myxovirus (influenza virus) resistance 2 (Mx2)
  • myxovirus (influenza virus) resistance 2 (mouse) (MX2)
  • AI528743 protein
  • Mx-2 protein
  • Mx3 protein
  • MXB protein

Protein level used designations for MX2

interferon-induced GTP-binding protein Mx2 , myxovirus resistance protein 2 , interferon-induced GTP-binding protein Mx3 , myxovirus (influenza virus) resistance 3 , myxovirus resistance protein 3 , interferon-regulated resistance GTP-binding protein MXB , p78-related protein , second interferon-induced protein p78 , Mx protein , myxovirus (influenza virus) resistance 2 , interferon-inducible protein p78 , GTP-binding protein Mx2 , myxovirus resistance 2

17858 Mus musculus
286918 Rattus norvegicus
4600 Homo sapiens
280873 Bos taurus
396893 Sus scrofa
780441 Ovis aries
403744 Canis lupus familiaris
780935 Macaca mulatta
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