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N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) Proteins (NAT2)

NAT2 encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Additionally we are shipping NAT2 Antibodies (59) and NAT2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAT2 116632 P50298
NAT2 10 P11245
NAT2 17961 P50295
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Top NAT2 Proteins at

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

NAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
Mouse (Murine)

More Proteins for N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) Interaction Partners

Human N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. NAT2 slow acetylation state was associated with bladder cancer risk, and was shown to modestly increase the risk of bladder cancer.

  2. the NAT2 slow acetylation genotypes might increase the susceptibility to pancreatic cancer in Europe but that these have no significant effects in the United States and multi-center populations.

  3. Findings suggest that variations in the NAT2 gene and their interactions contribute to occupational diisocyanate asthma susceptibility.

  4. The results suggest that NAT2 is related to cognitive processes dealing with distraction and attentional control in the auditory modality; ultra-slow acetylation status was associated with reduced higher cognitive functions

  5. Individuals with NAT2 slow acetylators may have increased risk of antituberculosis drug-induced liver injury when standard dose of isoniazid was used. [META-ANALYSIS]

  6. Findings support a role for NAT2 in modifying the association between red meat consumption and colorectal cancer in Japanese and African Americans.

  7. TT genotype in NAT2 C282T polymorphism may be a risk factor for lung cancer susceptibility. Additionally, the acetylator status of 5 SNPs in NAT2 gene may not be associated with lung cancer risk (Meta-Analysis)

  8. The pattern of variation of NAT2 in sub-Saharan African food-producing populations differs from that expected under a model of isolation-by-distance or from those observed with other genetic systems, but it is compatible with the hypothesis that it was shaped by selective pressures linked to the chemical environment in which populations evolved.

  9. N-acetyltransferase 2 gene polymorphism is associated with the susceptibility to bladder cancer.

  10. Data show correlation between N-acetyltransferase 2 (NAT2) gene polymorphism and cirrhotic portal hypertension in Chinese patients.

Mouse (Murine) N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. We found that MeCP2 (show MECP2 Proteins) acts as a microglia-specific transcriptional repressor of

  2. It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa.

  3. GlnT would promote both proliferation and neuronal differentiation through a mechanism relevant to the upregulation of particular proneural genes in undifferentiated P19 cells.

  4. Inner hair cells express glutamine transporter SLC38A1.

  5. Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation.

  6. In this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine transporters Snat3 (Slc38a3) and Snat1 (Slc38a1) was investigated in the mouse brain microvasculature.

  7. Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 (show EIF4G2 Proteins) gene expression with certain developmental malformations and cancers.

  8. Nat2 knockout mouse line demonstrates that different Nat2 isoforms have distinct functions with no compensatory expression, in Nat2 knockout animals, of the other isoforms.

  9. Variation in capacity for acetylation of 4ABP and PABA resulting from endogenous murine NAT2 alleles is insufficient to affect 4ABP genotoxicity in liver.

  10. Results suggest that peroxynitrite-dependent inactivation of NAT1 (show EIF4G2 Proteins) and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.

Rhesus Monkey N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. The study is the first to thoroughly characterize the properties of a polymorphic NAT isoenzyme in a non-human primate model.

NAT2 Protein Profile

Protein Summary

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).

Gene names and symbols associated with NAT2

  • N-acetyltransferase 2 (Nat2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (Nat2)
  • solute carrier family 38, member 1 (Slc38a1)
  • AA408026 protein
  • AA409865 protein
  • AAC2 protein
  • AL022800 protein
  • AT-2 protein
  • AT-B/AT-II protein
  • AT-II protein
  • AT2 protein
  • AU015942 protein
  • AV377607 protein
  • NAT protein
  • NAT-2 protein
  • NAT2 protein
  • Nat2a protein
  • PNAT protein

Protein level used designations for NAT2

AT-2 , N-Acetyltransferase-2 (arylamine N-acetyltransferase) , N-acetyltransferase 2 (arylamine N-acetyltransferase) , N-acetyltransferase type 2 , NAT-2 , arylamide acetylase 2 , arylamine N-acetyltransferase 2 , N-acetyl transferase 2 , PNAT , lambda R-1 , polymorphic arylamine N-acetyltransferase , Arylamide acetylase 2 , NAT2 15 , Polymorphic arylamine N-acetyltransferase , acetyltransferase , arylamine N-acetyltransferase-2 , MNat2 , N-system amino acid transporter 2 , amino acid transporter A1 , sodium-coupled neutral amino acid transporter 1 , system A amino acid transporter 1 , system N amino acid transporter 1

116632 Rattus norvegicus
10 Homo sapiens
17961 Mus musculus
100008974 Oryctolagus cuniculus
101840555 Mesocricetus auratus
704357 Macaca mulatta
105727 Mus musculus
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