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NAD(P)H Dehydrogenase, Quinone 1 Proteins (NQO1)

NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. Additionally we are shipping NQO1 Antibodies (196) and NQO1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NQO1 1728 P15559
NQO1 24314 P05982
NQO1 18104 Q64669
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Top NQO1 Proteins at

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
Human Un-conjugated   2 μg Log in to see 6 Days

NQO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Rat (Rattus)

Mouse (Murine)

Top referenced NQO1 Proteins

  1. Human NQO1 Protein expressed in Escherichia coli (E. coli) - ABIN668043 : Jaiswal, McBride, Adesnik, Nebert: Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. in The Journal of biological chemistry 1988 (PubMed)
    Show all 2 references for ABIN668043

More Proteins for NAD(P)H Dehydrogenase, Quinone 1 (NQO1) Interaction Partners

Human NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. significant structural and functional changes incurred by NQO1 antioxidant protein (show PRDX3 Proteins) as a result of alteration in its nucleotide, are reported.

  2. Study provides a comprehensive picture of the structural and dynamic consequences of NQO1 polymorphisms, linking changes in protein dynamics with impaired NQO1 function and FAD (show BRCA2 Proteins) binding, particularly for p.P187S, leading to increased cancer susceptibility.

  3. Polymorphism of the NQO1 Gene is associated with Breast Cancer.

  4. patients who carry the wild type genotype or only one polymorphism for either NQO1 or GSTP1 (show GSTP1 Proteins) gene have possibly a better clinical outcome after the natalizumab therapy.

  5. The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (show MTHFR Proteins) c.677C>T p.A222V(rs1801133), TP53 (show TP53 Proteins) c.215C>G p.R72P (rs1042522), NQO1 c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 Proteins) alleles imputed as fast acetylator genotypes. [meta-analysis]

  6. Results show that NQO1 is up-regulated in non-small cell lung neoplasm which correlates with poor survival.

  7. Meta-analysis. our results showed that NQO1 C609T polymorphism increases the risk of Alzheimer disease in Chinese populations.

  8. The present study revealed that NQO1 CT, TT and CT+TT genotypes may be associated with clinical outcome and risk of developing NSCLC in the Indian population.

  9. Flavin reductase (show BLVRB Proteins) and calreticulin (show CALR Proteins) play key roles in the development of pemetrexed-associated resistance in lung adenocarcinoma cells.

  10. NQO1 was significantly increased in all of the diseased livers including peri (show PLIN1 Proteins)-hepatocellular carcinoma tissues.

Mouse (Murine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. NQO1 plays a critical role in protection against energy depletion in acetaminophen-induced liver injury, and is associated with improvement of mitochondrial dysfunction

  2. The present results demonstrate that exacerbated cisplatin-induced nephrotoxicity under the NQO1-knockout condition was accompanied by the reduced expression of MRN complex proteins, ATM (show ATM Proteins), PARP1 (show PARP1 Proteins), and Sirt1 (show SIRT1 Proteins).

  3. Taken together, these data suggest that EEEC attenuates oxidative stress by activating Nrf2 (show NFE2L2 Proteins)-mediated HO-1 (show HMOX1 Proteins) and inducing NQO-1 via the activation of MAPK (show MAPK1 Proteins) signaling pathways.

  4. We defined the basal and butylated hydroxyanisole induced expression patterns of Nqo1, AKR1B8, and Ho-1 (show HMOX1 Proteins) in the liver and small intestine of C57BL/6 mice.

  5. The colons of NQO1-KO mice also showed high levels of reactive oxygen species (ROS (show ROS1 Proteins)) and histone deacetylase (HDAC (show HDAC1 Proteins)) activity, which are known to affect transcriptional regulation.

  6. the induction of cellular NAD(+) levels using beta-lapachone (beta-Lap), whose intracellular target is NQO1, prevents the toxic effects of cisplatin through the regulation of PARP-1 (show PARP1 Proteins) and SIRT1 (show SIRT1 Proteins) activity.

  7. Nqo1 expression is protective against renal ischemia/reperfusion injury in mice.

  8. results indicate that AAI can increase its own metabolic activation by inducing NQO1, thereby enhancing its own genotoxic potential.

  9. PCB-77 induced reductions in insulin (show INS Proteins) signaling in adipose tissue were also abolished by Resveratrol, which increased NQO1 expression.

  10. NQO1 does not play a major role in the production of vitamin K hydroquinone and supports the existence of multiple vitamin K reduction pathways.

Pig (Porcine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. The obtained data convincingly showed that porcine NADPH-d cells may produce nitric oxide.

  2. Immunoreactivity of eNOS (show NOS3 Proteins) was similar to NADPH-d staining. Clear iNOS (show NOS2 Proteins) immunoreactivity was detected in the luminal epithelium, endometrial stroma and individual endometrial glands.

NQO1 Protein Profile

Protein Summary

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with NQO1

  • NAD(P)H dehydrogenase, quinone 1 (nqo1)
  • NAD(P)H dehydrogenase, quinone 1 (NQO1)
  • NAD(P)H dehydrogenase, quinone 1 (Bpet2092)
  • NAD(P)H dehydrogenase, quinone 1 (Nqo1)
  • AV001255 protein
  • DHQU protein
  • Dia4 protein
  • Dtd protein
  • NADPH-d protein
  • Nmo-1 protein
  • Nmo1 protein
  • Nmor1 protein
  • NMORI protein
  • nqo1 protein
  • Ox-1 protein
  • Ox1 protein
  • Qr1 protein
  • wu:fb63c10 protein
  • zgc:77191 protein

Protein level used designations for NQO1

NAD(P)H dehydrogenase [quinone] 1 , NAD(P)H menadione oxidoreductase 1, dioxin-inducible , NAD(P)H dehydrogenase, quinone 1 , DT-diaphorase , DTD , NAD(P)H:quinone oxidoreductase 1 , QR1 , azoreductase , menadione reductase , phylloquinone reductase , quinone reductase 1 , nad(p)h dehydrogenase (quinone) 1 , NAD(P)H:Quinone acceptor oxidoreductase type 1 , NAD(P)H:menadione oxidoreductase 1 , NAD(P)H:quinone oxireductase , diaphorase (NADH/NADPH) (cytochrome b-5 reductase) , diaphorase-4 , dioxin-inducible 1 , Diaphorase (NADH/NADPH) , NAD(P)H:menadione oxidoreductase , NAD(P)H dehydrogenase (quinone) , NAD(P)H menadione oxidoreductase 1, dioxin inducible , diaphorase 4 (NADH/NADPH) , nicotinamide adenine dinucleotide phosphate diaphorase , diaphorase 4 , NAD(P)H: quinone oxidoreductase 1

322506 Danio rerio
468012 Pan troglodytes
549222 Xenopus (Silurana) tropicalis
705635 Macaca mulatta
769737 Gallus gallus
4606922 Azoarcus sp. BH72
5818094 Bordetella petrii DSM 12804
100049751 Xenopus laevis
100172039 Pongo abelii
100528193 Ictalurus punctatus
1728 Homo sapiens
610935 Canis lupus familiaris
24314 Rattus norvegicus
18104 Mus musculus
100286873 Sus scrofa
519632 Bos taurus
100135582 Cavia porcellus
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