NQO1 Protein (His tag)

Catalog No. ABIN7197091

Product Details

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This NQO1 protein is labelled with His tag.

Purpose: Recombinant Human NQO1/DT-diaphorase Protein (His Tag)

Sequence: Met 1-Lys274

Characteristics: A DNA sequence encoding the mature form of human NQO1 (P15559-1) (Met1-Lys274) was expressed with a polyhistide tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Alternative Name: NQO1/DT-diaphorase (NQO1 Products)

Synonyms: zgc:77191 Protein, wu:fb63c10 Protein, nqo1 Protein, DHQU Protein, DIA4 Protein, DTD Protein, NMOR1 Protein, NMORI Protein, QR1 Protein, Dia4 Protein, AV001255 Protein, Dtd Protein, Nmo-1 Protein, Nmo1 Protein, Nmor1 Protein, Ox-1 Protein, Ox1 Protein, Qr1 Protein, NADPH-d Protein, NAD(P)H dehydrogenase, quinone 1 Protein, NAD(P)H quinone dehydrogenase 1 Protein, NAD(P)H dehydrogenase, quinone 1 L homeolog Protein, nqo1 Protein, NQO1 Protein, Bpet2092 Protein, nqo1.L Protein, Nqo1 Protein

Background:

Background: NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.

Synonym: DHQU,DIA4,DTD,NMOR1,NMORI,QR1

Molecular Weight: 33 kDa