N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) Proteins (NAT2)

NAT2 encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Additionally we are shipping NAT2 Antibodies (63) and NAT2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAT2 116632 P50298
NAT2 10 P11245
NAT2 17961 P50295
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Top NAT2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Macaca mulatta His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
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Yeast Mesocricetus auratus His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
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Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details

NAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
,
Mouse (Murine)

More Proteins for N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) Interaction Partners

Human N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. Study reestablished the association between NAT2 SA and isoniazid-induced liver injury in a Singaporean population and demonstrated its clinical validity in prediction of isoniazid-induced liver injury.

  2. In non-syndromic cleft lip with or without cleft palate, we found a significant association between the EGF61 (rs4444903) and NSCL (show NHLH1 Proteins)/P (P = .01) genes. Conversely, NAT2 (rs1799929) was not significantly different between the cases and the control group

  3. 182 Hungarian bladder cancer cases and 78 cancer-free controls were investigated. It was not possible to establish a particular impact of NAT2*6A and *7B genotypes (15 cases, 8%, 5 controls, 7%). GSTT1 (show GSTT1 Proteins) exerted no marked influence on bladder cancer (negative 21% cases vs. 22% controls). The portion of GSTM1 (show GSTM1 Proteins) negative bladder cancer patients was increased (63% cases vs. 54% controls).

  4. Various antitubercular isoniazid dosing regimens have been proposed for NAT2-specific immunocompetent and immune-deficient patient populations.

  5. Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1 (show AOX1 Proteins)), NAT2 (N-acetyltransferase 2), AADAC (arylacetamide deacetylase (show AADAC Proteins)), and CYP3A4 (cytochrome P450 3A4 (show CYP3A4 Proteins)).

  6. The multicolor melting curve assay described in our study is very promising for the efficient determination of NAT2 genotype, and can facilitate the personalized dosing of isoniazid

  7. No significant differences in the acetylator NAT2 haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering.

  8. In any patient who may receive INH and happens to be NAT2 slow acetylator type, NAT2 genotype by covert action may influence the clinical response of above drugs.

  9. Homozygous mutant allele of NAT2 gene at 481site may act as a predisposing factor for phenytoin intoxication among tuberculous meningitis or tuberculoma patients having seizures.

  10. In the present study, we report that the most common NAT2 haplotype in the Korean population (TACGAGG; frequency = 47.6%) is associated with a low expression level of NAT2. We failed to find a significant relationship between rs4646241 and enzyme expression level. Haplotypes of Caucasian and African populations were markedly different from those of the Korean population.

Mouse (Murine) N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells

  2. We found that MeCP2 acts as a microglia-specific transcriptional repressor of

  3. It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa.

  4. GlnT would promote both proliferation and neuronal differentiation through a mechanism relevant to the upregulation of particular proneural genes in undifferentiated P19 cells.

  5. Inner hair cells express glutamine transporter SLC38A1.

  6. Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation.

  7. In this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine transporters Snat3 (Slc38a3) and Snat1 (Slc38a1) was investigated in the mouse brain microvasculature.

  8. Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 (show EIF4G2 Proteins) gene expression with certain developmental malformations and cancers.

  9. Nat2 knockout mouse line demonstrates that different Nat2 isoforms have distinct functions with no compensatory expression, in Nat2 knockout animals, of the other isoforms.

  10. Variation in capacity for acetylation of 4ABP and PABA resulting from endogenous murine NAT2 alleles is insufficient to affect 4ABP genotoxicity in liver.

Rhesus Monkey N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. The study is the first to thoroughly characterize the properties of a polymorphic NAT isoenzyme in a non-human primate model.

NAT2 Protein Profile

Protein Summary

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).

Gene names and symbols associated with NAT2

  • N-acetyltransferase 2 (Nat2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (Nat2)
  • solute carrier family 38, member 1 (Slc38a1)
  • AA408026 protein
  • AA409865 protein
  • AAC2 protein
  • AL022800 protein
  • AT-2 protein
  • AT-B/AT-II protein
  • AT-II protein
  • AT2 protein
  • AU015942 protein
  • AV377607 protein
  • NAT protein
  • NAT-2 protein
  • NAT2 protein
  • Nat2a protein
  • PNAT protein

Protein level used designations for NAT2

AT-2 , N-Acetyltransferase-2 (arylamine N-acetyltransferase) , N-acetyltransferase 2 (arylamine N-acetyltransferase) , N-acetyltransferase type 2 , NAT-2 , arylamide acetylase 2 , arylamine N-acetyltransferase 2 , N-acetyl transferase 2 , PNAT , lambda R-1 , polymorphic arylamine N-acetyltransferase , Arylamide acetylase 2 , NAT2 15 , Polymorphic arylamine N-acetyltransferase , acetyltransferase , arylamine N-acetyltransferase-2 , MNat2 , N-system amino acid transporter 2 , amino acid transporter A1 , sodium-coupled neutral amino acid transporter 1 , system A amino acid transporter 1 , system N amino acid transporter 1

GENE ID SPECIES
116632 Rattus norvegicus
10 Homo sapiens
17961 Mus musculus
100008974 Oryctolagus cuniculus
101840555 Mesocricetus auratus
704357 Macaca mulatta
105727 Mus musculus
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