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NHL Repeat Containing 1 Proteins (NHLRC1)

The protein encoded by NHLRC1 is a single subunit E3 ubiquitin ligase. Additionally we are shipping NHLRC1 Antibodies (52) and NHLRC1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NHLRC1 378884 Q6VVB1
NHLRC1 105193 Q8BR37
NHLRC1 364682 Q6IMG5
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Top NHLRC1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

NHLRC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for NHL Repeat Containing 1 (NHLRC1) Interaction Partners

Human NHL Repeat Containing 1 (NHLRC1) interaction partners

  1. Malin promotes its own degradation via auto-ubiquitination.Malin preferentially degrades the phosphatase-inactive laforin (show EPM2A Proteins) monomer.

  2. laforin/malin complex is able to interact with and ubiquitinate both PKM1 and PKM2

  3. Lafora disease proteins laforin (show EPM2A Proteins) and malin negatively regulate the HIPK2 (show HIPK2 Proteins)-p53 (show TP53 Proteins) cell death pathway.

  4. This study demonistrated that NHLRC1 mutations were detected in some case of Mild Lafora disease patients.

  5. Without functional laforin (show EPM2A Proteins)-malin complex assembled on polyglucosan bodies, polyglucosan is not degraded.

  6. Malin regulates the recruitment of mRNA-decapping enzyme 1A (Dcp1a (show DCP1A Proteins)) to processing bodies.

  7. Malin forms a functional complex with laforin (show EPM2A Proteins). This complex promotes the ubiquitination of proteins involved in glycogen (show GYS1 Proteins) metabolism and misregulation of pathways involved in this process results in Lafora body formation. (Review)

  8. This study identified that NHLRC1 gene mutations leading to Lafora disease in six Turkish families.

  9. Our results indicate that malin regulates Wnt (show WNT2 Proteins) signaling pathway through the degradation of dishevelled2 and suggest possible deregulation of Wnt (show WNT2 Proteins) signaling in Lafora disease.

  10. Mutations in the NHL repeat containing 1 (NHLRC1) gene are described in association with a more benign clinical course and later age of death in an adolescent patient.

Mouse (Murine) NHL Repeat Containing 1 (NHLRC1) interaction partners

  1. This study also suggests a malin function independent of laforin (show EPM2A Proteins), possibly in lysosomal biogenesis and/or lysosomal glycogen (show GYS1 Proteins) disposal.

  2. Results indicate that malin has no effect on whole-body glucose metabolism and insulin (show INS Proteins) sensitivity.

  3. Dysfunction of autophagy is a common feature of both laforin (show EPM2A Proteins)- and malin-deficient mice.

  4. malin functions to regulate laforin (show EPM2A Proteins) and that malin deficiency at least in part causes LB and LD through increased laforin (show EPM2A Proteins) binding to glycogen (show GYS1 Proteins).

  5. Results show that a functional laforin (show EPM2A Proteins)-malin complex plays a critical role in disrupting Lafora bodies and relieving endoplasmic reticulum stres.

  6. Motor coordination, activity impairment, and memory deficits progressively increase with age in Epm2b deficient mice.

  7. Data conclude that EPM2B functions to maintain laforin (show EPM2A Proteins) associated with soluble glycogen (show GYS1 Proteins) and that its absence causes sequestration of laforin (show EPM2A Proteins) to an insoluble polysaccharide fraction where it is functionally inert.

  8. laforin (show EPM2A Proteins) and malin play a role protecting cells from ER-stress, likely contributing to the elimination of unfolded proteins

NHLRC1 Protein Profile

Protein Summary

The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as progressive myoclonic epilepsy type 2 (EPM2).

Gene names and symbols associated with NHLRC1

  • NHL repeat containing 1 (NHLRC1)
  • thiopurine S-methyltransferase (TPMT)
  • NHL repeat containing 1 (LOC100341052)
  • NHL repeat containing 1 (Nhlrc1)
  • AI505271 protein
  • B230309E09Rik protein
  • bA204B7.2 protein
  • EPM2A protein
  • Epm2b protein
  • MALIN protein
  • malin-like protein
  • NHLRC1 protein

Protein level used designations for NHLRC1

NHL repeat containing 1 , thiopurine methyltransferase , NHL repeat-containing protein 1 , malin , E3 ubiquitin-protein ligase NHLRC1 , NHL repeat-containing protein 1-like

428477 Gallus gallus
471863 Pan troglodytes
474161 Canis lupus familiaris
538814 Bos taurus
704451 Macaca mulatta
747581 Pan troglodytes
100066209 Equus caballus
100341052 Oryctolagus cuniculus
100443623 Pongo abelii
378884 Homo sapiens
105193 Mus musculus
364682 Rattus norvegicus
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