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NLR Family, Pyrin Domain Containing 3 Proteins (NLRP3)

NLRP3 encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. Additionally we are shipping NLRP3 Antibodies (167) and NLRP3 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
Rat NLRP3 NLRP3 287362  
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Top NLRP3 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag   2 μg Log in to see 9 Days

NLRP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Top referenced NLRP3 Proteins

  1. Human NLRP3 Protein expressed in Wheat germ - ABIN1312675 : Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012 (PubMed)
    Show all 4 references for ABIN1312675

More Proteins for NLR Family, Pyrin Domain Containing 3 (NLRP3) Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. NLRP3 gene rs10754558 polymorphisms are associated with increased risk of metabolic syndrome

  2. Findings suggest that immune-activation in the frontal cortex may occur both in patients with bipolar disorderand schizophrenia, while complex I dysfunction and NLRP3-inflammasome activation may be more specific to bipolar disorder

  3. we found no significant association between NALP3 gene polymorphisms and the risk of primary gout.

  4. NLRP3 inflammasome in subcutaneous adipose tissue may have a role in atherogenesis

  5. NLRP3 polymorphism may have a role in diabetic macrovascular complications, especially in myocardial infarction

  6. NLRP3 expression, and not the inflammasome activation, is required for epithelial-mesenchymal transition in colorectal cancer cells.

  7. These results demonstrated that the close relationship between the expression of NLRP3 signaling pathway and human carotid atherosclerotic plaques.

  8. role of the influenza virus NS1 (show PTPN11 Proteins) protein in activating the NLRP3 inflammasome

  9. NALP3 inflammasome is expressed in the inflammatory periapical tissues. This cytokine-signalling pathway may therefore be crucial in the regulatory control of inflammatory responses in periapical tissues and the development of periapical lesions

  10. PPARgamma (show PPARG Proteins) prevented NALP3 inflammasome formation and IL1beta (show IL1B Proteins) production in HK2 (show HK2 Proteins) cells stimulated by monosodium urate crystals

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. enhanced ERK (show EPHB2 Proteins) signaling in Drp1 (show CRMP1 Proteins)-knockdown macrophages is implicated in the potentiation of NLRP3 inflammasome activation, via mediating mitochondrial localization of NLRP3 to facilitate the assembly of NLRP3 inflammasome

  2. studies have uncovered the combined actions of the NLRP3 inflammasome and caspase 8 (show CASP8 Proteins) leading to IL-1beta (show IL1B Proteins) maturation and the directionality of IL-1beta (show IL1B Proteins) in driving disease inPstpip2(cmo (show PSTPIP2 Proteins))mice.

  3. The data reveal that Nlrp3 inflammasome-dependent IL-1beta (show IL1B Proteins), associated with localized neutrophil recruitment, plays a crucial role in the development of a nonhealing form of cutaneous leishmaniasis in conventionally resistant mice.

  4. Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 (show IL10 Proteins) Mediated Regulation of NLRP3 Expression and Caspase-8 (show CASP8 Proteins) Activation

  5. While both contributing to pathogen clearance, NLRP3 more than NLRC4 (show NLRC4 Proteins) contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Proteins) and correlates with defective NLRC4 (show NLRC4 Proteins)-dependent IL-1Ra (show IL1RN Proteins) production.

  6. The pro-inflammatory and cancer-promoting effects of a high cholesterol diet are mediated by the activation of NLRP3.

  7. Results suggest that astroglial NLRP3 inflammasome complexes are critically involved in neuroinflammation in amyotrophic lateral sclerosis

  8. that generation of reactive oxygen species and potassium efflux contribute to HIV-induced pyroptosis and NLRP3 inflammasome activation in podocytes

  9. Data (including data from studies in knockout mice) suggest NLRP3 is not required for activation of macrophages and dendritic cells by soluble saponin adjuvant, QS-21, in mice immunized with HIV-1 glycoprotein 120 subunit vaccine.

  10. Rotavirus infection in macrophages depend on MAVS (show MAVS Proteins) but not involve the NLRP3 inflammasome nor JNK (show MAPK8 Proteins) and p38 (show CRK Proteins) signal pathway.

NLRP3 Protein Profile

Protein Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene names and symbols associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3)
  • NLR family, pyrin domain containing 3 (LOC100351623)
  • NLR family, pyrin domain containing 3 (nlrp3)
  • NLR family, pyrin domain containing 3 (Nlrp3)
  • AGTAVPRL protein
  • AII protein
  • AII/AVP protein
  • AVP protein
  • C1orf7 protein
  • Cias1 protein
  • CLR1.1 protein
  • FCAS protein
  • FCU protein
  • Mmig1 protein
  • MWS protein
  • NALP3 protein
  • Pypaf1 protein

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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