You are viewing an incomplete version of our website. Please click to reload the website as full version.

NLR Family, Pyrin Domain Containing 3 Proteins (NLRP3)

NLRP3 encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. Additionally we are shipping NLRP3 Antibodies (193) and NLRP3 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
Rat NLRP3 NLRP3 287362  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top NLRP3 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag   2 μg Log in to see 9 Days

NLRP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Top referenced NLRP3 Proteins

  1. Human NLRP3 Protein expressed in Wheat germ - ABIN1312675 : Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012 (PubMed)
    Show all 4 references for ABIN1312675

More Proteins for NLR Family, Pyrin Domain Containing 3 (NLRP3) Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. NLRP3 (rs4612666) single-nucleotide polymorphisms with ageing and/or smoking habit potentially might play a significant role in the pathogenic pathways of periodontal disease.

  2. Levels of NLRP3 and IL1beta (show IL1B Proteins) were positively correlated with adipocyte diameter in male, but not in female cancer patients.

  3. High expression of NLRP3, NLRC4 (show NLRC4 Proteins), and CASP1 (show CASP1 Proteins) in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma.

  4. identical amino acid substitutions related to NLRP3 mutations are known to be sometimes associated with different phenotype suggesting the involvement of additional genetic and environmental factors

  5. Results indicate that NLRP3 inflammasome plays a vital role in regulating the proliferation and migration of A549 lung cancer cells.

  6. Our findings for the first time show that the NLRP3 rs10754558 polymorphism is involved in the occurrence of CAD in the Chinese Han population; and G allele can effectively predict clinical outcome of CAD. The G allele susceptibility to CAD is maybe associated with the increased level of serum IL-1b (show IL1B Proteins).

  7. We now show that ADAM10 (show ADAM10 Proteins) is critical for alpha-hemolysin (show PLC Proteins)-mediated activation of the NLRP3 inflammasome in human monocytes as siRNA knockdown or chemical blockade of ADAM10 (show ADAM10 Proteins)-alpha-hemolysin (show PLC Proteins) interaction leads to diminished inflammasome activation and cell death by reducing the available ADAM10 (show ADAM10 Proteins) on the cell surface.

  8. There is a significant association between rs3806268 in NLRP3 gene and the risk of primary gout in a Chinese population.

  9. the NLRP3 inflammasome is dysregulated in idiopathic pulmonary fibrosis but not in rheumatoid arthritis-usual interstitial pneumonia

  10. The NLRP3 rs3806265 T allele was significantly more frequent in the patients with RAS than in the healthy controls.

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. Hepatic NLRP3 inflammasome activation played an important role in the development of non-alcoholic fatty liver disease via relA (show NFkBP65 Proteins) phosphorylation.

  2. NMDAR1 (show GRIN1 Proteins) plays a pivotal role in hemin-induced NLRP3-mediated inflammatory damage through synergistic activation.

  3. Renal medullary Nlrp3 inflammasomes regulate renal medullary blood flow and sodium excretion.

  4. our study demonstrated that ablating the NLRP3 gene significantly reduced neuroinflammation and delayed RGC loss after optic nerve crush injury.

  5. Data show that NLR family pyrin domain containing 3 (Nlrp3) gene silencing abolished the visfatin (show NAMPT Proteins)-induced high mobility group box (show SSRP1 Proteins) protein 1 (HMGB1 (show HMGB1 Proteins)) release from vascular endothelial cell (MVEC).

  6. Sertoli cells have a functional NALP3 inflammasome that modulates NOD1 (show NOD1 Proteins) and pro-IL-1beta (show IL1B Proteins) expression, while NOD2 inversely promoted IL-1beta (show IL1B Proteins) expression.

  7. Melatonin also attenuated the expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase (show CASP3 Proteins) recruitment domain (ASC (show STS Proteins)), cleaved caspase-1 (show CASP1 Proteins), interleukin-1beta (IL-1beta (show IL1B Proteins)), and interleukin-6 (IL-6 (show IL6 Proteins)); these changes were also associated with an increase in the anti-apoptotic factor (Bcl2 (show BCL2 Proteins)) and reduction in the pro-apoptotic factor (Bim (show BCL2L11 Proteins)).

  8. Poly-ADP-ribosylation-mediated degradation of ARTD1 (show PARP1 Proteins) by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.

  9. provides a direct link between miR-7 (show LILRB1 Proteins) and NLRP3 inflammasome-mediated neuroinflammation in the pathogenesis of Parkinson's disease

  10. GHR (show GHR Proteins)-dependent downregulation of NLRP3 inflammasome in macrophages is linked to pro-longevity effects that maintain immune system homeostasis in aging.

NLRP3 Protein Profile

Protein Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene names and symbols associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3)
  • NLR family, pyrin domain containing 3 (LOC100351623)
  • NLR family, pyrin domain containing 3 (nlrp3)
  • NLR family, pyrin domain containing 3 (Nlrp3)
  • AGTAVPRL protein
  • AII protein
  • AII/AVP protein
  • AVP protein
  • C1orf7 protein
  • Cias1 protein
  • CLR1.1 protein
  • FCAS protein
  • FCU protein
  • Mmig1 protein
  • MWS protein
  • NALP3 protein
  • Pypaf1 protein

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
Selected quality suppliers for NLRP3 Proteins (NLRP3)
Did you look for something else?