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NLR Family, Pyrin Domain Containing 3 Proteins (NLRP3)

NLRP3 encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. Additionally we are shipping NLRP3 Antibodies (187) and NLRP3 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
Rat NLRP3 NLRP3 287362  
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Top NLRP3 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag   2 μg Log in to see 9 Days

NLRP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Top referenced NLRP3 Proteins

  1. Human NLRP3 Protein expressed in Wheat germ - ABIN1312675 : Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012 (PubMed)
    Show all 4 references for ABIN1312675

More Proteins for NLR Family, Pyrin Domain Containing 3 (NLRP3) Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. we propose that the NLRP3 rs10754558 polymorphism contributes to the development of type 2 diabetes mellitus but that rs7512998 and rs12137901 variants are not associated with susceptibility to this disease.

  2. In patients with Age-Related Macular Degeneration increased mRNA levels of NLRP3 are observed.

  3. The proteins of NLRP3, ASC (show PYCARD Proteins), and caspase-1 (show CASP1 Proteins) were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.

  4. Necrotic trophoblastic debris induced endothelial cell activation through the IL-1beta (show IL1B Proteins)/IL-1R pathway. However, the NALP3 inflammasome in endothelial cells was not involved in this process.

  5. Uropathogenic Escherichia coli activates an NLRP3-independent cell death pathway and an aalpha-hemolysin-independent IL-1beta secretion (show IL1B Proteins)pathway in human macrophages.

  6. NLRP3 gene rs10754558 polymorphisms are associated with increased risk of metabolic syndrome

  7. Findings suggest that immune-activation in the frontal cortex may occur both in patients with bipolar disorderand schizophrenia, while complex I dysfunction and NLRP3-inflammasome activation may be more specific to bipolar disorder

  8. we found no significant association between NALP3 gene polymorphisms and the risk of primary gout.

  9. NLRP3 inflammasome in subcutaneous adipose tissue may have a role in atherogenesis

  10. NLRP3 polymorphism may have a role in diabetic macrovascular complications, especially in myocardial infarction

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

  2. AUthors demonstrated, for the first time, that gammaT3 inhibits the NLRP3 inflammasome thereby delaying the progression of type 2 diabetes.

  3. diabetes-associated chronic inflammatory response may have contributed to impaired socket wound healing and rendered oral wound susceptible to the development of bisphosphonate-related osteonecrosis of the jaw via NLRP3 activation in macrophages

  4. Dietary manipulation evokes a maladaptive response in heart mice, as demonstrated by the shift of myosin heavy chain isoform content from alpha to beta, the increased expression of the Nlrp3 inflammasome and markers of oxidative metabolism.

  5. Chronic obstructive pulmonary disease and NLRP3 knockout mice were 5.0 +/- 1.0%, 78.1 +/- 9.2% and 2.0 +/- 0.9%, respectively

  6. NLRP3 was involved in BU/CY-induced liver inflammation after HSCT and selectively inhibited it ameliorated liver inflammation and improved liver function, suggesting targeting NLRP3 might be a new approach in the prophylaxis of liver inflammation

  7. In mouse macrophages, uropathogenic Escherichia coli-triggered inflammasome responses are completely NLRP3-dependent, triggered IL-1beta (show IL1B Proteins) secretion, and were largely alpha-hemolysin (show PLC Proteins)-dependent.

  8. enhanced ERK (show EPHB2 Proteins) signaling in Drp1 (show CRMP1 Proteins)-knockdown macrophages is implicated in the potentiation of NLRP3 inflammasome activation, via mediating mitochondrial localization of NLRP3 to facilitate the assembly of NLRP3 inflammasome

  9. studies have uncovered the combined actions of the NLRP3 inflammasome and caspase 8 (show CASP8 Proteins) leading to IL-1beta (show IL1B Proteins) maturation and the directionality of IL-1beta (show IL1B Proteins) in driving disease inPstpip2(cmo (show PSTPIP2 Proteins))mice.

  10. The data reveal that Nlrp3 inflammasome-dependent IL-1beta (show IL1B Proteins), associated with localized neutrophil recruitment, plays a crucial role in the development of a nonhealing form of cutaneous leishmaniasis in conventionally resistant mice.

NLRP3 Protein Profile

Protein Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene names and symbols associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3)
  • NLR family, pyrin domain containing 3 (LOC100351623)
  • NLR family, pyrin domain containing 3 (nlrp3)
  • NLR family, pyrin domain containing 3 (Nlrp3)
  • AGTAVPRL protein
  • AII protein
  • AII/AVP protein
  • AVP protein
  • C1orf7 protein
  • Cias1 protein
  • CLR1.1 protein
  • FCAS protein
  • FCU protein
  • Mmig1 protein
  • MWS protein
  • NALP3 protein
  • Pypaf1 protein

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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