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Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Additionally we are shipping NUAK1 Antibodies (80) and many more products for this protein.
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ARK5 was upregulated in ovarian cancer tissues, promoted epithelialmesenchymal transition and inhibited miR (show MLXIP Proteins)-1181 expression in ovarian cancer cells
MiR (show MLXIP Proteins)-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.
Overexpression of NUAK1 is associated with disease-free survival and overall survival in patients with gastric cancer.
Data indicate that miR-96 suppresses the expression of (nua) kinase family 1 (NUAK1) by targeting its 3' untranslated region (3' UTR).
Results indicate that NUAK1 is excessively expressed in NSCLC and plays important roles in NSCLC invasion.
Expression of NUAK1 is controlled by cyclin-dependent kinase (show CDK1 Proteins), PLK1, and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase (show MUL1 Proteins) complex.
We demonstrate that miR (show MLXIP Proteins)-211 contributes to melanoma adhesion by directly targeting a gene, NUAK1.
Overexpression of ARK5 is associated with hepatocellular carcinoma.
High NUAK1 expression correlates with poor prognosis and involved in human nonsmall cell lung cancer cells migration and invasion.
ARK5 can promote glioma cell invasion by regulating cytoskeleton rearrangement and matrix metalloproteinase (show MMP20 Proteins) activation.
Study shows that LKB1 (show STK11 Proteins) is necessary and sufficient for terminal axon branching of cortical neurons through the activation of NUAK1, an AMPK (show PRKAA1 Proteins)-related kinase whose function during brain development was unknown.
NUAK1 knockdown reduced lung metastasis in a xenograft mouse model of nonsmall cell lung cancer.
NUAK1 and NUAK2 (show NUAK2 Proteins) complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
in human and murine cell lines, oncogenic levels of MYC (show MYC Proteins) establish a dependence on AMPK (show PRKAA1 Proteins)-related kinase 5 for maintaining metabolic homeostasis and for cell survival; ARK5 is an upstream regulator of AMPK (show PRKAA1 Proteins) and limits protein synthesis via inhibition of the mammalian target of rapamycin (show FRAP1 Proteins) 1 (mTORC1) signalling pathway
a physiological role of NUAK1 is to suppress glucose uptake through negative regulation of insulin (show INS Proteins) signaling in oxidative muscle.
Omphk1 expression is also found in each tissue associated with the ventral body wall closure: the primary body wall composed of primitive ectoderm and each component of the secondary body wall [Omphk1]
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
AMP-activated protein kinase family member 5
, AMPK-related protein kinase 5
, NUAK family SNF1-like kinase 1
, omphalocele kinase 1
, ZNUAK family, SNF1-like kinase, 1