anti-Neurofilament, Light Polypeptide (NEFL) Antibodies

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Additionally we are shipping Neurofilament, Light Polypeptide Kits (39) and Neurofilament, Light Polypeptide Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NEFL 18039 P08551
NEFL 4747 P07196
NEFL 83613 P19527
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Top anti-Neurofilament, Light Polypeptide Antibodies at

Showing 10 out of 273 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
REACT_Bird Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Western blot of whole rat cerebellum homogenate stained with ABIN152477, at dilution of 1:20,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~68kDa corresponds to rodent NF-L. Human, cow and bovine NF-L run a little slower, at about 70kDa. Immunocytochemistry/Immunofluorescence: 68kDa Neurofilament Light Antibody [ABIN152477] - Mixed neuron/glia cultures from newborn rat brain stained with ABIN152477 antibody to peripherin (green) and rabbit polyclonal antibody to NF-L RPCA-NF-L (red channel). A class of large neurons, like the one in the middle of this image, contain peripherin, while the majority of neurons and their processes contain NF-L and not peripherin. Interestingly, the periperin positive cells often contain a cytoplasmic inclusion next to the nucleus which stains for both peripherin and NF-L, and so appears golden in this kind of image. The blue channel reveals the localization of DNA 0.05 mL Log in to see 7 to 9 Days
Cat Mouse Un-conjugated IHC (fro), IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
Human Mouse Un-conjugated EIA, FACS, IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
REACT_Bird Mouse Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Rat spinal cord homogenate showing the major intermediate filament proteins of the nervous system (lane 1). The remaining lanes show blots of this material stainted with various antibodies including ABIN152478 (lane 4). Simple Western: NF-L Antibody (DA2) [ABIN152478] - Simple Western lane view shows a specific band for NF-L in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.05 mL Log in to see 7 to 9 Days
Human Chicken Un-conjugated IF, IHC (p), WB Tissue section through an adult Mouse brain showing NFL (brown staining) of axons in the white matter of the cerebellum. 0.3 mg Log in to see 6 to 8 Days
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of Jurkat cells using NEFL mouse mAb (green) and negative control (red) . 0.1 mg Log in to see 2 to 3 Days
Chicken Mouse Un-conjugated IF, WB   0.1 mL Log in to see 12 to 15 Days
Human Mouse Un-conjugated IHC (fro), IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
Chicken Chicken Un-conjugated IF, IHC (fro), WB   0.1 mL Log in to see 12 to 15 Days
Human Rabbit Un-conjugated IHC (p) <b>Immunohistochemistry</b> analysis of NF-L in human lung carcinoma tissue (Formalin-fixed, Paraffin-embedded) using Neurofilament L antibody . 0.1 mg Log in to see 6 to 8 Days

NEFL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Neurofilament, Light Polypeptide Antibodies

  1. Bird (Avian) Polyclonal NEFL Primary Antibody for ICC, IF - ABIN152477 : King, Dickson, Blizzard, Woodhouse, Foster, Chung, Vickers: Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. in Neurobiology of aging 2011 (PubMed)
    Show all 7 Pubmed References

  2. Bird (Avian) Monoclonal NEFL Primary Antibody for ICC, IF - ABIN152478 : King, Dickson, Blizzard, Foster, Chung, West, Chuah, Vickers: Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons. in The European journal of neuroscience 2007 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal NEFL Primary Antibody for ICC, FACS - ABIN969548 : Lee, Kim, Chung, Kim, Kwon, Min, Chang: The effect of rod domain A148V mutation of neurofilament light chain on filament formation. in BMB reports 2009 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal NEFL Primary Antibody for ICC, FACS - ABIN969549 : Abe, Numakura, Saito, Koide, Oka, Honma, Kishikawa, Hayasaka: Neurofilament light chain polypeptide gene mutations in Charcot-Marie-Tooth disease: nonsense mutation probably causes a recessive phenotype. in Journal of human genetics 2009 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal NEFL Primary Antibody for PLA, WB - ABIN518282 : Madeddu, Farace, Tolu, Solinas, Asara, Sotgiu, Delogu, Prados, Sotgiu, Montella: Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013 (PubMed)

  6. Monoclonal NEFL Primary Antibody for IHC (fro), IF - ABIN534044 : Edson, Linck, Letourneau: Identification of a tektin-like protein associated with neurofilaments in the developing chick nervous system. in Journal of neuroscience research 1992 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Neurofilament, Light Polypeptide Interaction Partners

Mouse (Murine) Neurofilament, Light Polypeptide (NEFL) interaction partners

  1. Nefl(N98S/+) mice had a noticeable tremor, and most animals showed a hindlimb clasping similar to human Charcot-Marie-Tooth Type 2E phenotype.

  2. The finding of this study suggested that a lack of NFL protein alters the expression of cytoskeletal proteins and disrupts other NF subunits, causing intracellular aggregation but not gross structural changes in cortical neurons or cytoarchitecture.

  3. Neurofilament light chain (NFL) and neuronal intermediate filament protein (show GFAP Antibodies) alpha-internexin (show INA Antibodies) accumulate in axon swellings in the spinal white matter in a superoxide dismutase (SOD)-1 (show SOD1 Antibodies) mouse model.

  4. Data suggest that tetrahydropapaveroline (an endogenous catechol) causes oxidative stress resulting in astrocyte/neuronal cell death via generation of reactive oxygen species and modification/aggregation of NF-L (as in neurodegenerative diseases).

  5. Data show that mitochondria essentially stopped moving in neurons expressing neurofilament protein (NFL) mutants, probably a consequence of cytoskeletal disruption.

  6. Myo (show SYNPO2 Antibodies) Va interactions with intermediate filament proteins may serve similar roles in organizing organelle topography in different cell types.

  7. NEFL transgenic mice exhibited extended duration of the hindlimb clasping response and gait anomalies, as well as sensorimotor deficits in stationary beam and suspended bar tests

  8. Neuropathic effects of overexpressing NF-L can occur at the level of transgene RNA and are mediated by sequences in the NF-L 3' UTR (show UTS2R Antibodies)

  9. nNOS (show NOS1 Antibodies) inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum

  10. The 3' untranslated region of light neurofilament (NF-L) transcript enhances the reactivity of its own translated product and leads to loss of solubility and aggregation of NF-L protein and to coaggregation of mutant superoxide dismutase 1 (SOD1 (show SOD1 Antibodies)) protein

Human Neurofilament, Light Polypeptide (NEFL) interaction partners

  1. Results show that both alphaS and NFL can be phosphorylated by CKII (show CSNK2A1 Antibodies), PLK2 (show PLK2 Antibodies) and PLK3 (show PLK3 Antibodies), but Ser129 in alphaS is a preferential site for PLK2 (show PLK2 Antibodies) and PLK3 (show PLK3 Antibodies), demonstrating higher phosphorylation efficiency. Comparatively, CKII (show CSNK2A1 Antibodies) preferentially phosphorylates Ser473 in NFL and this site can be phosphorylated by PLK1 (show PLK1 Antibodies), 2 and 3, but these enzymes prefer to modify other sites within NFL.

  2. Results provide evidence that in particular pNfH can be used as a good diagnostic biomarker of ALS (show IGFALS Antibodies) at the diagnostic stage. Moreover, results indicate that NfL may be useful in monitoring disease progression in a subset of patients.

  3. Level of neurofilament heavy chain and light chains were significantly elevated in the cerebrospinal fluid of Amyotrophic Lateral Sclerosis (ALS) patients compared to healthy controls/controls without parenchymal central nervous system involvement and ALS mimic disease patients.

  4. Results from 2 independent prospective cohort studies show that serum NFL is a sensitive and dynamic biomarker for axonal injury in concussive traumatic brain injury. The marker should be useful to detect and monitor CNS injury in concussion

  5. Findings support the potential value of serum NfL as a marker of neuroaxonal injury in early multiple sclerosis. Its reduction over time could represent regression to the mean, or a possible treatment effect of IFN-beta (show IFNB1 Antibodies)-1a. Association with whole brain atrophy and formation of acute white matter lesions has implications to use serum NfL as a biomarker of the overall consequences of brain damage and ongoing disease acti...

  6. Higher serum NfL concentrations are associated with more rapid brain atrophy and may therefore reflect disease intensity in dementia (FTD (show FTL Antibodies)). Because blood sampling is less invasive and has better patient acceptability than lumbar puncture, serum NfL may provide important prognostic information and prove to be a useful outcome measure for clinical trials in FTD (show FTL Antibodies).

  7. We conclude that the NEFL N98S mutation is associated with a dominant intermediate Charcot-Marie-Tooth disease phenotype characterized by early-onset sensorimotor neuropathy delaying motor milestones, which may evolve into a severe and complex clinical picture including cerebellar ataxia.

  8. Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection

  9. The results showed an important role for miR (show MLXIP Antibodies)-25 in regulating NEFL expression in Glioblastoma multiforme.

  10. Finally, we demonstrated that NEFL inhibited the NF-kappaB (show NFKB1 Antibodies) pathway, thereby suppressing the expression of uPA (show PRAP1 Antibodies) and decreasing NSCLC invasiveness and migration.

Neurofilament, Light Polypeptide (NEFL) Antigen Profile

Protein Summary

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Gene names and symbols associated with NEFL

  • neurofilament, light polypeptide (NEFL) antibody
  • neurofilament, light polypeptide b (neflb) antibody
  • neurofilament, light polypeptide (Nefl) antibody
  • neurofilament, light polypeptide (nefl) antibody
  • AI847934 antibody
  • CMT1F antibody
  • CMT2E antibody
  • nefl antibody
  • NF-L antibody
  • NF68 antibody
  • NFL antibody
  • XNF-L antibody
  • zgc:136626 antibody

Protein level used designations for NEFL

neurofilament, light polypeptide 68kDa , neurofilament, light polypeptide , neurofilament light polypeptide , 68 kDa neurofilament protein , neurofilament protein L , neurofilament triplet L protein , light molecular weight neurofilament protein , neurofilament protein, light chain , neurofilament subunit NF-L , NF-L , micro glutamic acid-rich protein , neurofilament protein , Neurofilament triplet L protein

464063 Pan troglodytes
477378 Canis lupus familiaris
641444 Macaca mulatta
664698 Danio rerio
18039 Mus musculus
4747 Homo sapiens
83613 Rattus norvegicus
281348 Bos taurus
100521224 Sus scrofa
397822 Xenopus laevis
419528 Gallus gallus
100173482 Pongo abelii
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