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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Additionally we are shipping Neurofilament, Light Polypeptide Kits (39) and Neurofilament, Light Polypeptide Proteins (12) and many more products for this protein.
Showing 10 out of 273 products:
Bird (Avian) Polyclonal NEFL Primary Antibody for ICC, IF - ABIN152477
King, Dickson, Blizzard, Woodhouse, Foster, Chung, Vickers: Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. in Neurobiology of aging 2011
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Bird (Avian) Monoclonal NEFL Primary Antibody for ICC, IF - ABIN152478
King, Dickson, Blizzard, Foster, Chung, West, Chuah, Vickers: Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons. in The European journal of neuroscience 2007
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Human Monoclonal NEFL Primary Antibody for ICC, FACS - ABIN969548
Lee, Kim, Chung, Kim, Kwon, Min, Chang: The effect of rod domain A148V mutation of neurofilament light chain on filament formation. in BMB reports 2009
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Human Monoclonal NEFL Primary Antibody for ICC, FACS - ABIN969549
Abe, Numakura, Saito, Koide, Oka, Honma, Kishikawa, Hayasaka: Neurofilament light chain polypeptide gene mutations in Charcot-Marie-Tooth disease: nonsense mutation probably causes a recessive phenotype. in Journal of human genetics 2009
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Human Polyclonal NEFL Primary Antibody for PLA, WB - ABIN518282
Madeddu, Farace, Tolu, Solinas, Asara, Sotgiu, Delogu, Prados, Sotgiu, Montella: Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013
Monoclonal NEFL Primary Antibody for IHC (fro), IF - ABIN534044
Edson, Linck, Letourneau: Identification of a tektin-like protein associated with neurofilaments in the developing chick nervous system. in Journal of neuroscience research 1992
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Nefl(N98S/+) mice had a noticeable tremor, and most animals showed a hindlimb clasping similar to human Charcot-Marie-Tooth Type 2E phenotype.
The finding of this study suggested that a lack of NFL protein alters the expression of cytoskeletal proteins and disrupts other NF subunits, causing intracellular aggregation but not gross structural changes in cortical neurons or cytoarchitecture.
Neurofilament light chain (NFL) and neuronal intermediate filament protein (show GFAP Antibodies) alpha-internexin (show INA Antibodies) accumulate in axon swellings in the spinal white matter in a superoxide dismutase (SOD)-1 (show SOD1 Antibodies) mouse model.
Data suggest that tetrahydropapaveroline (an endogenous catechol) causes oxidative stress resulting in astrocyte/neuronal cell death via generation of reactive oxygen species and modification/aggregation of NF-L (as in neurodegenerative diseases).
Data show that mitochondria essentially stopped moving in neurons expressing neurofilament protein (NFL) mutants, probably a consequence of cytoskeletal disruption.
Myo (show SYNPO2 Antibodies) Va interactions with intermediate filament proteins may serve similar roles in organizing organelle topography in different cell types.
NEFL transgenic mice exhibited extended duration of the hindlimb clasping response and gait anomalies, as well as sensorimotor deficits in stationary beam and suspended bar tests
Neuropathic effects of overexpressing NF-L can occur at the level of transgene RNA and are mediated by sequences in the NF-L 3' UTR (show UTS2R Antibodies)
nNOS (show NOS1 Antibodies) inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum
The 3' untranslated region of light neurofilament (NF-L) transcript enhances the reactivity of its own translated product and leads to loss of solubility and aggregation of NF-L protein and to coaggregation of mutant superoxide dismutase 1 (SOD1 (show SOD1 Antibodies)) protein
Results show that both alphaS and NFL can be phosphorylated by CKII (show CSNK2A1 Antibodies), PLK2 (show PLK2 Antibodies) and PLK3 (show PLK3 Antibodies), but Ser129 in alphaS is a preferential site for PLK2 (show PLK2 Antibodies) and PLK3 (show PLK3 Antibodies), demonstrating higher phosphorylation efficiency. Comparatively, CKII (show CSNK2A1 Antibodies) preferentially phosphorylates Ser473 in NFL and this site can be phosphorylated by PLK1 (show PLK1 Antibodies), 2 and 3, but these enzymes prefer to modify other sites within NFL.
Results provide evidence that in particular pNfH can be used as a good diagnostic biomarker of ALS (show IGFALS Antibodies) at the diagnostic stage. Moreover, results indicate that NfL may be useful in monitoring disease progression in a subset of patients.
Level of neurofilament heavy chain and light chains were significantly elevated in the cerebrospinal fluid of Amyotrophic Lateral Sclerosis (ALS) patients compared to healthy controls/controls without parenchymal central nervous system involvement and ALS mimic disease patients.
Results from 2 independent prospective cohort studies show that serum NFL is a sensitive and dynamic biomarker for axonal injury in concussive traumatic brain injury. The marker should be useful to detect and monitor CNS injury in concussion
Findings support the potential value of serum NfL as a marker of neuroaxonal injury in early multiple sclerosis. Its reduction over time could represent regression to the mean, or a possible treatment effect of IFN-beta (show IFNB1 Antibodies)-1a. Association with whole brain atrophy and formation of acute white matter lesions has implications to use serum NfL as a biomarker of the overall consequences of brain damage and ongoing disease acti...
Higher serum NfL concentrations are associated with more rapid brain atrophy and may therefore reflect disease intensity in dementia (FTD (show FTL Antibodies)). Because blood sampling is less invasive and has better patient acceptability than lumbar puncture, serum NfL may provide important prognostic information and prove to be a useful outcome measure for clinical trials in FTD (show FTL Antibodies).
We conclude that the NEFL N98S mutation is associated with a dominant intermediate Charcot-Marie-Tooth disease phenotype characterized by early-onset sensorimotor neuropathy delaying motor milestones, which may evolve into a severe and complex clinical picture including cerebellar ataxia.
Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection
The results showed an important role for miR (show MLXIP Antibodies)-25 in regulating NEFL expression in Glioblastoma multiforme.
Finally, we demonstrated that NEFL inhibited the NF-kappaB (show NFKB1 Antibodies) pathway, thereby suppressing the expression of uPA (show PRAP1 Antibodies) and decreasing NSCLC invasiveness and migration.
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
neurofilament, light polypeptide 68kDa
, neurofilament, light polypeptide
, neurofilament light polypeptide
, 68 kDa neurofilament protein
, neurofilament protein L
, neurofilament triplet L protein
, light molecular weight neurofilament protein
, neurofilament protein, light chain
, neurofilament subunit NF-L
, micro glutamic acid-rich protein
, neurofilament protein
, Neurofilament triplet L protein