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Niemann-Pick Disease, Type C2 Proteins (NPC2)

NPC2 encodes a protein containing a lipid recognition domain. Additionally we are shipping NPC2 Antibodies (70) and NPC2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPC2 67963 Q9Z0J0
NPC2 10577 P61916
NPC2 286898  
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Top NPC2 Proteins at

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Yeast Dog His tag Niemann-Pick Disease, Type C2 (NPC2) (AA 22-149), (full length) protei... 500 μg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Dog His tag 50 μg Log in to see 21 to 26 Days
Yeast Dog His tag 50 μg Log in to see 31 to 36 Days
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days

NPC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
Rat (Rattus)

More Proteins for Niemann-Pick Disease, Type C2 (NPC2) Interaction Partners

Mouse (Murine) Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. These findings show that NPC2 secreted by premalignant lung tumours suppresses immature macrophage-lineage cell recruitment to the microenvironment in a paracrine manner.

  2. Using the inhibitors of cathepsin enzymatic activity, it was found that cathepsins B and L regulate TNF-alpha (show TNF Proteins) production, the expression and secretion of NPC2 protein, and the mRNA levels of the genes involved in cholesterol trafficking in macrophages.

  3. Npc1 (show NPC1 Proteins) and npc2 deficiencies result in pulmonary abnormalities observed in human Niemann-Pick type C disease.

  4. This is the first report demonstrating that GNMT (show GNMT Proteins) plays an important role in regulating cholesterol homeostasis via interaction with NPC2

  5. NPC1 (show NPC1 Proteins) and NPC2 proteins participate in endosomal/lysosomal processing of both sphingolipids and cholesterol

  6. In liver, absence of either NPC1 (show NPC1 Proteins) or NPC2 resulted in similar alterations in the carbohydrate processing of the lysosomal protease, tripeptidyl peptidase I (show TPP1 Proteins).

  7. The lack of fibronectin (show FN1 Proteins) did not interfere with reconstruction of collagen fibril organization in response to liver injury.

  8. NPC2 is a positive regulator of biliary cholesterol secretion via stimulation of ABCG5 (show ABCG5 Proteins)/G8-mediated cholesterol transport.

  9. Studies showed that processing and export of sterol from the late E/L compartment was quantitatively different in mice lacking LAL (show LIPA Proteins), NPC2, or NPC1 (show NPC1 Proteins) function.

  10. NPC2 as a novel intracrine/autocrine factor that controls adipocyte differentiation and function

Human Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. Structure of glycosylated NPC1 (show NPC1 Proteins) luminal domain C reveals insights into NPC2 and Ebola virus interactions

  2. hypothesize that, in part, NPC2 rapidly traffics cholesterol between closely appositioned membranes within the multilamellar interior of late endosomal/lysosomal proteins, ultimately effecting cholesterol egress from this compartment

  3. NPC2 may play an important role in negatively regulate cell proliferation.

  4. heterozygous mutations in the NPC1 (show NPC1 Proteins)/2 gene might be a risk factor for Alzheimer's disease

  5. Data suggest that in order for the ligand cholesterol to slide from one binding pocket to the other (from NPC2 to NPC1 (show NPC1 Proteins)), cholesterol undergoes conformational change/isomerization to accommodate the bent transfer pathway between the 2 binding pockets.

  6. Suggest role for mouse epididymal NPC2 in regulating male fertility.

  7. twelve individuals were subsequently confirmed to be NP-C by DNA analysis of NPC1 (show NPC1 Proteins) and NPC2 genes, with the early infantile form, the late infantile form, the juvenile form, and the adult form

  8. Recombinant NPC2 protein increases triglyceride levels in body fat.

  9. these results suggest that the vitamin A-mediated antimicrobial mechanism against M. tuberculosis requires NPC2-dependent expression and function, indicating a key role for cellular cholesterol regulation in the innate immune response.

  10. The p.Pro120Ser causing mutation in NPC2 observed in the Iranian patients was earlier observed in the only other NPC2 patient reported from the Middle East.

Cow (Bovine) Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. Data suggest ASM (acid sphingomyelinase (show SMPD1 Proteins)) activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2 (Niemann Pick protein type C2); hydrolysis of sphingomyelin by ASM (show SMPD1 Proteins) may be crucial for endosomal lipid degradation/sorting.

  2. Data show that the effects of the lipids on cholesterol transfer mediated by NPC2 were similar to their effect on membrane fusion induced by NPC2 and saposin-C.

  3. analysis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease

  4. The seminal plasma protein, Niemann-Pick C2 protein, is involved in cholesterol and GM1 depletion within detergent-resistant membrane, then leading to membrane redistribution of P25b that occurs in a very rapid and capacitation-independent manner.

  5. NPC2 plays an important role in endo/lysosomal cholesterol trafficking by markedly accelerating the rates of cholesterol transport. Rates of sterol transfer from and between membranes were increased by as much as 2 orders of magnitude by NPC2.

NPC2 Protein Profile

Protein Summary

This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.

Gene names and symbols associated with NPC2

  • Niemann Pick type C2 (Npc2)
  • Niemann-Pick disease, type C2 (NPC2)
  • Niemann-Pick disease, type C2 (Npc2)
  • Niemann-Pick disease, type C2 (npc2)
  • 2700012J19Rik protein
  • AA408070 protein
  • AU045843 protein
  • cb292 protein
  • CE1 protein
  • EDDM1 protein
  • EPI-1 protein
  • HE1 protein
  • re1 protein
  • sb:cb292 protein

Protein level used designations for NPC2

epididymal secretory protein E1 , mE1 , niemann Pick type C2 protein homolog , Niemann-Pick disease type C2 protein , epididymal protein 1 , human epididymis-specific protein 1 , tissue-specific secretory protein , Niemann Pick type C2 , epididymal secretory protein 1 , EPV20 , 16 kDa secretory protein , 16kDa secretory protein , 16.5 kDa secretory protein

67963 Mus musculus
10577 Homo sapiens
286898 Rattus norvegicus
280815 Bos taurus
403920 Canis lupus familiaris
397410 Sus scrofa
450192 Pan troglodytes
282673 Danio rerio
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