NPC1L1 Proteins
(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
| Catalog no. | Product | Reactivity | Host / Clonality | Application | Price & lead time |
|---|---|---|---|---|---|
| NPC1L1 Protein (DYKDDDDK Tag) | Human | HEK-293 Cells |
|
$9,292.54
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|
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| NPC1L1 Protein (AA 22-284) (His tag) | Human | HEK-293 Cells |
|
$604.14
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|
|
| NPC1L1 Protein (His tag) | Human | Escherichia coli (E. coli) |
|
$345.09
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|
|
| NPC1L1 Protein (DYKDDDDK Tag,Strep Tag) | Human | HEK-293 Cells |
|
$8,370.70
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|
|
| NPC1L1 Protein (AA 450-620) (His tag) | Human | Bacteria |
|
$495.00
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|
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| NPC1L1 Protein (His tag) | Human | Escherichia coli (E. coli) |
|
$478.00
View price
|
Protein
- ELISA (ELISA: Validation image available)
- SDS (SDS-PAGE: Validation image available)
- Imm (Immunogen: Listed application)
- cryo-EM (Cryogenic electron microscopy: Listed application)
- PhD (Phage Display: Listed application)
- SPR (Surface Plasmon Resonance: Listed application)
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Synthetic Nanodisc
Catalog No. ABIN7491703
$9,292.54
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 25 to 32 Business Days
Protein
- SDS (SDS-PAGE: Validation image available)
- AM (Affinity Measurement: Listed application)
- ADA (Antibody Drug Assay: Listed application)
- IA (Immunoassay: Listed application)
- ScA (Screening Assay: Listed application)
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Catalog No. ABIN7490787
$604.14
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 12 to 15 Business Days
Protein
- ELISA (ELISA: Listed application)
- SDS (SDS-PAGE: Listed application)
- WB (Western Blotting: Listed application)
- Origin
- Human
- Host
- Escherichia coli (E. coli)
- Protein Type
- Recombinant
Catalog No. ABIN7578509
$345.09
Plus shipping costs $50.00
100 μg
Shipping to:
United States
Delivery in 12 to 15 Business Days
Protein
- ELISA (ELISA: Listed application)
- Imm (Immunogen: Listed application)
- cryo-EM (Cryogenic electron microscopy: Listed application)
- PhD (Phage Display: Listed application)
- SPR (Surface Plasmon Resonance: Listed application)
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Synthetic Nanodisc
Catalog No. ABIN7854138
$8,370.70
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 40 to 52 Business Days
Catalog No. ABIN7817794
$495.00
Plus shipping costs $50.00, if applicable $20.00 dry ice
100 μg
Shipping to:
United States
Delivery in 7 to 10 Business Days
Protein
- ELISA (ELISA: Listed application)
- Imm (Immunogen: Listed application)
- SDS (SDS-PAGE: Listed application)
- WB (Western Blotting: Listed application)
- Origin
- Human
- Host
- Escherichia coli (E. coli)
- Protein Type
- Recombinant
Catalog No. ABIN7947387
$478.00
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 8 to 12 Business Days
Aliases for NPC1L1 Proteins
NPC1 like intracellular cholesterol transporter 1 (NPC1L1) ProteinsNPC1 like 1 (npc1l1) Proteins
NPC1-like 1 (npc1l1) Proteins
NPC1 like intracellular cholesterol transporter 1 (Npc1l1) Proteins
9130221N23Rik Proteins
Gm243 Proteins
NPC1L1 Proteins
NPC11L1 Proteins
Did you look for something else?
- NPAS4 Proteins
- NPAS2 Proteins
- NOXO1 Proteins
- NOXA1 Proteins
- NOXA Proteins
- NOX5 Proteins
- NOX3 Proteins
- NOX1 Proteins
- NOVA1 Proteins
- NOV Proteins
- NOTUM Proteins
- NOTCH4 Proteins
- NOTCH3 Proteins
- NOTCH2NL Proteins
- NOTCH2 Proteins
- Notch1 Proteins
- NOTCH-Regulated Ankyrin Repeat Protein Proteins
- NOSTRIN Proteins
- NOSIP Proteins
- NOS2 Proteins
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