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OX encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Additionally we are shipping Orexin Kits (18) and many more products for this protein.
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Mouse (Murine) Polyclonal OX Primary Antibody for EIA, WB - ABIN492717
Sakurai, Moriguchi, Furuya, Kajiwara, Nakamura, Yanagisawa, Goto: Structure and function of human prepro-orexin gene. in The Journal of biological chemistry 1999
Show all 5 references for ABIN492717
Awake dynamics and brain-wide direct inputs of hypothalamic MCH (show PMCH Antibodies) and orexin/hypocretin networks have been discovered.
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency
observation that inhibition of the Orexin-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin circuits participate in the consumption of salient reinforcers regardless of calories.
Results suggest that exercise produces antidepressant effects via suppression of Hcrt/Orx and melanin-concentrating hormone (show PMCH Antibodies) neural systems in the basolateral amygdala
Hcrt neuronal activity and Hcrt-mediated stress responses were inhibited by the satiety hormone leptin (show LEP Antibodies).
This study demonstrated that the GABAergic input property of orexin neurons responds rapidly to sleep deprivation.
sleep deprivation or increasing wakefulness by rescue of orexinergic neurons in APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) mice lacking orexin increased the amount of amyloid beta pathology in the brain.
orexin activates the mTOR (show FRAP1 Antibodies) pathway, a central regulator of cell growth and metabolism, in the mouse brain and cell lines that express GPCRs, OX1R (show HCRTR1 Antibodies), or OX2R (show CD200R1 Antibodies)
This study demonistrated that absence of the Hcrt peptide has gender-specific effects. In contrast, Hcrt-ataxin mice and human narcoleptics, with loss of the whole Hcrt cell, show weight gain in both sexes.
These results suggest that orexin neuronal activity plays a crucial role in the maintenance of wakefulness especially in the active phase in mice.
This is the first time a seasonal variation of hcrt-1 levels has been shown, demonstrating that the hcrt system is, like other neurotransmitter systems, subjected to long term modulation
Significantly reduced csf (show CSF2 Antibodies) levels of hypocretin-1 were found in cluster headache patients compared with controls.
Results from homology and docking modeling show two alternative binding modes for orexin-A into orexin 1 receptor in concordance with what is known of G protein coupled receptors activation in general and the mutational data.
Patients with schizophrenia had a significantly higher plasma HCRT level than healthy controls. Patients in the high-orexin subgroup had significantly fewer negative and disorganized symptoms, and tended to have fewer perseverative errors.
Data suggest that interaction between the nociceptin/nociceptin (show PNOC Antibodies) receptor (show OPRL1 Antibodies) system and the orexin/orexin receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
Orexin A upregulates the protein expression of OX1R (show HCRTR1 Antibodies) and enhances the proliferation of SGC (show SGCB Antibodies)-7901 gastric cancer cells through the ERK (show EPHB2 Antibodies) signaling pathway.
Orexin receptor binding was strongly dependent on the extracellular Ca(2 (show CA2 Antibodies)+) concentration.
No significant differences were found in the distribution of either genotypic or allelic frequencies between Alzheimer's disease cases and controls in the HCRT polymorphisms.
Hypocretin, MOG (show MOG Antibodies), or DNMT1 (show DNMT1 Antibodies) mutations are exceptional findings in DQB1*06:02 negative narcolepsy cases with hypocretin deficiency
In patients with narcolepsy with cataplexy, deficient CSF (show CSF2 Antibodies) HCRT levels were correlated with lower muscle sympathetic nerve activity and heart rate.
The aim of the study was to determine by immunochemistry the expression of leptin (show LEP Antibodies), orexin A and orphanin FQ (show PNOC Antibodies) in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
first evidence for the expression of oxA and ox1R (show HCRTR1 Antibodies) in the vestibular glands of mammalian genital tract
The impact of the phase of the estrous cycle on the observed changes in plasma orexin levels in domestic pigs.
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
Hypocretin (orexin) neuropeptide
, orexin A
, orexin B