PTEN Induced Putative Kinase 1 Proteins (PINK1)

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. Additionally we are shipping PINK1 Antibodies (237) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
Rat PINK1 PINK1 298575  
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Top PINK1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 15 to 19 Days
$319.00
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$640.00
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HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$672.00
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human MBP tag,His tag   100 μg Log in to see 5 to 8 Days
$683.55
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HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$845.63
Details

PINK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , , ,
Mouse (Murine) ,
, ,

Top referenced PINK1 Proteins

  1. Human PINK1 Protein expressed in Escherichia coli (E. coli) - ABIN667580 : Valente, Salvi, Ialongo, Marongiu, Elia, Caputo, Romito, Albanese, Dallapiccola, Bentivoglio: PINK1 mutations are associated with sporadic early-onset parkinsonism. in Annals of neurology 2004 (PubMed)
    Show all 2 references for 667580

More Proteins for PTEN Induced Putative Kinase 1 (PINK1) Interaction Partners

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin (show PARK2 Proteins) flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  2. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin (show PARK2 Proteins) and for subsequent phosphorylation and activation of Parkin (show PARK2 Proteins).

  3. A pink1 genomic knock-in allele was generated to monitor the dynamic expression pattern of PINK1. The spatiotemporal expression pattern of PINK1 correlates with the cell-type specific mitochondrial clearance or persistence. PINK1 and PARKIN (show PARK2 Proteins) function epistatically to mediate timely specific mitophagy during Drosophila midgut metamorphosis.

  4. Our data indicate that PINK1 and Parkin (show PARK2 Proteins) play an important role in FUS (show FUS Proteins)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (show FUS Proteins) proteinopathy and PINK1/Parkin (show PARK2 Proteins) genes, providing new insights into the pathogenesis of FUS (show FUS Proteins) proteinopathy.

  5. we show that overexpression of Drosophila Clu (show CLU Proteins) complements PINK1, but not parkin (show PARK2 Proteins), mutant muscles. Thus, Clu (show CLU Proteins) is essential for mitochondrial homeostasis and functions in concert with Parkin (show PARK2 Proteins) and VCP (show vcp Proteins) for Marf (show MFN2 Proteins) degradation to promote damaged mitochondrial clearance.

  6. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1 (show RAP1GDS1 Proteins), played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF (show SLC2A4RG Proteins) member.

  7. Buffy has a role enhancing the loss of parkin (show PARK2 Proteins) and suppressing the loss of Pink1 phenotypes in Drosophila

  8. PINK1-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  9. Clu (show CLU Proteins) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  10. Human Mask homolog ANKHD1 (show ANKHD1 Proteins) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin (show PARK2 Proteins) mutations.

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Adipogenic process can be dissected into 3 stages according to the participation of PARL (show PARL Proteins)-PINK1-Parkin (show PARK2 Proteins) system. Findings reveal the sequential adipogenic events directed by PARL (show PARL Proteins)-PINK1-Parkin (show PARK2 Proteins) system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease

  2. PKA-mediated phosphorylation of MIC60 negatively regulates mitochondrial clearance that is initiated by PINK1 and Parkin (show PARK2 Proteins).

  3. We report that loss of PINK1 contributes to the Warburg effect through ROS (show ROS1 Proteins)-dependent stabilization of hypoxia-inducible factor-1A and reduced pyruvate kinase muscle isozyme 2 activity which highlight the importance of PINK1 and reactive oxygen species balance in normal and tumor cells.

  4. PINK1 disease mutants failed to recruit synphilin-1 (show SNCAIP Proteins) and did not activate mitophagy, indicating that PINK1-synphilin-1 (show SNCAIP Proteins)-SIAH-1 (show SIAH1 Proteins) represents a new parkin (show PARK2 Proteins)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

  5. PINK1 p.G411S is a rare genetic risk factor with a relatively large effect size conferred by a partial dominant-negative function phenotype.

  6. In summary, our results demonstrate that PINK1 promoted hepatic IR via JNK (show MAPK8 Proteins) and ERK (show EPHB2 Proteins) pathway in PA treated HepG2 cells, implying a novel molecular target for the therapy of diabetes.

  7. the results suggest that BNIP3 (show BNIP3 Proteins) plays a vital role in regulating PINK1 mitochondrial outer membrane localization, the proteolytic process of PINK1 and PINK1/parkin (show PARK2 Proteins)-mediated mitophagy under physiological conditions.

  8. PINK1 interferes with selective mitochondrial fission and mitophagy.

  9. findings suggest that PINK1 and PARKIN (show PARK2 Proteins) play critical roles in selective cell death in which damaged mitochondria are retained, independent of mitochondrial autophagy.

  10. findings underscore the importance of a mitophagy regulatory network of ATM (show ATM Proteins) and PINK1/Parkin (show PARK2 Proteins) and elucidate a novel mechanism by which ATM (show ATM Proteins) influences spermidine-induced mitophagy

Mouse (Murine) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. study identifies a new role of Dual-AKAP1 (show AKAP1 Proteins) in regulating mitochondrial trafficking through Miro-2 (show RHOT2 Proteins), and supports a model in which PINK1 and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity

  2. Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS (show TLR4 Proteins)-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 can protect the immature brain against cell apoptosis induced by LPS (show TLR4 Proteins)-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS (show TLR4 Proteins)-sensitized HI brain damage in PINK1-knockout neonatal mice

  3. the results suggest that BNIP3 (show BNIP3 Proteins) plays a vital role in regulating PINK1 mitochondrial outer membrane localization, the proteolytic process of PINK1 and PINK1/parkin (show PARK2 Proteins)-mediated mitophagy under physiological conditions.

  4. lack of PINK1 causes increased excitatory transmission and neurotransmitter release in the hippocampus, which might lead to the cognitive decline often observed in Parkinson's disease

  5. The identification of PINK1 and Parkin (show PARK2 Proteins) as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  6. PINK1 deficiency causes defects in GFAP (show GFAP Proteins)-positive astrogliogenesis during brain development.

  7. The findings of this study show a CB1R (show CNR1 Proteins) dysfunction at corticostriatal synapses in PINK1(-/-), but not in PINK1(+/-) mice, and provide a mechanistic link to the distinct plasticity deficits observed in both genotypes.

  8. Loss of PINK1 inhibits Ca2+ efflux by NCLX and triggers mitochondrial depolarization.

  9. PINK1 gene knockout can protect neonatal mice from hypoxic-ischemic brain damage (HIBD).

  10. Loss of Pink1 reprograms glucose metabolism through HIF1alpha (show HIF1A Proteins), sustaining increased cell proliferation.

PINK1 Protein Profile

Protein Summary

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene names and symbols associated with PINK1

  • PTEN-induced putative kinase 1 (Pink1)
  • PTEN induced putative kinase 1 (PINK1)
  • PTEN induced putative kinase 1 (pink1)
  • PTEN induced putative kinase 1 (Pink1)
  • 1190006F07Rik protein
  • AU042772 protein
  • AW557854 protein
  • BEST:GH23468 protein
  • BRPK protein
  • CG4523 protein
  • Dmel\\CG4523 protein
  • dPink1 protein
  • mFLJ00387 protein
  • PARK6 protein
  • PINK protein
  • pink1 protein
  • wu:fc39e12 protein
  • zgc:101729 protein

Protein level used designations for PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

GENE ID SPECIES
31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
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