Perilipin 1 Proteins (PLIN1)

The protein encoded by PLIN1 coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. Additionally we are shipping PLIN1 Antibodies (120) and PLIN1 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLIN1 5346 O60240
PLIN1 103968 Q8CGN5
PLIN1 25629 P43884
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Top PLIN1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,470.50
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HOST_Escherichia coli (E. coli) Mouse GST tag,His tag   100 μg Log in to see 15 to 18 Days
$608.00
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PLIN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Perilipin 1 (PLIN1) Interaction Partners

Human Perilipin 1 (PLIN1) interaction partners

  1. The PLIN 6 polymorphism of the perilipin gene may influence the risk of obesity during adolescence.

  2. Variability at the PLIN1 locus is associated with variability in weight loss. Moreover, eating late is related to lower weight-loss effectiveness among carriers of the AA genotype at the PLIN1 14995A>T variant.

  3. The strong association of PLIN1, CFD (show CFD Proteins) and ADIPOQ (show ADIPOQ Proteins) genes with adipogenesis prompted authors to study the influence the bone health status as evaluated by quantitative ultrasound (QUS) bone densitometer in a North Indian cohort. Overall, ADIPOQ (show ADIPOQ Proteins) (rs1501299 and rs3774261) and combined cluster of PLIN1 rs2304796 and rs2304795) and CFD (show CFD Proteins) (rs1683563) demonstrated correlation.

  4. Perilipin 1 expression increased with adipocytic differentiation of liposarcoma subtypes showing statistical significance.

  5. Based on the PCR with mismatched primers PLIN1 polymorphisms could be identified effectively in Chinese Han population.

  6. Conserved amphipathic helices mediate lipid droplet targeting of PLIN1, PLIN2 (show PLIN2 Proteins), and PLIN3 (show PLIN3 Proteins).

  7. Skeletal muscle PLIN proteins likely play a role in the hydrolysis of triglycerides stored in lipid droplets and the passage of fatty acids to the mitochondria for oxidation.

  8. The functional PLIN1 rs6496589 may influence the risk of central obesity through possible regulation of lipid storage.

  9. After bariatric surgery-induced weight loss, PLIN1 gene/protein expression in SAT increased significantly. Findings suggest a positive functional interaction between PLIN1 & mitochondrial biogenesis-related genes in human adipose tissue.

  10. Use of molecular docking software to design perilipin-1 inhibitors as antiobesity agents.

Cow (Bovine) Perilipin 1 (PLIN1) interaction partners

  1. Perilipin, which was thought to be characteristic for lipid droplets of adipocytes and steroidogenic cells, becomes de novo expressed in hepatocytes of human, mouse, and cattle liver.

Mouse (Murine) Perilipin 1 (PLIN1) interaction partners

  1. ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7 (show AQP7 Proteins), and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7 (show AQP7 Proteins), thereby reducing complex formation

  2. Here, we identify synthetic ligands that release ABHD5 (show ABHD5 Proteins) from PLIN1 or PLIN5 (show PLIN5 Proteins) without PKA activation and rapidly activate adipocyte and muscle lipolysis.

  3. Heterozygous Plin1+/- SVCs were able to develop lipid droplets, with both the number and size more than in Plin1-/- SVCs but less than in Plin1+/+ SVCs, indicating that Plin1 haploinsufficiency accounts for attenuated adipogenesis.

  4. Plin1 deficiency in bone marrow-derived cells may be responsible for reduced atherosclerotic lesions in the mice

  5. Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion.

  6. Data suggest cardiotrophin-1 (show CTF1 Proteins) up-regulates lipolysis in adipocytes via 1) induction of Plin1, 2) activation of hormone sensitive lipase (show LIPE Proteins) (via phosphorylation by PKA), and 3) inactivation of adipose triglyceride lipase (show PNPLA2 Proteins) (via up-regulation of G0S2 (show G0S2 Proteins)).

  7. Adipocytes of Plin1/ mice showed robust basal lipolysis and fatty acid efflux to the plasma. Such adipose tissue dysfunctions accounted for the ectopic lipid accumulation and enhanced fatty acid transport and oxidation in Plin1/ hearts.

  8. QRFP-43 attenuates lipolysis by preventing the formation of an active complex between perilipin A, caveolin-1 (show CAV1 Proteins), the catalytic subunit of protein kinase (show CDK7 Proteins) and hormone-sensitive lipase (show LIPE Proteins) on lipid droplets.

  9. ESR1 (show ESR1 Proteins) regulates ATGL (show PNPLA2 Proteins) and perilipin-mediated lipid metabolism and droplet size in femurs from mice.

  10. Collectively these data suggest that whereas perilipin 1 potently suppresses basal lipolysis in adipocytes, perilipins 2 and 3 facilitate higher rates of basal lipolysis

Pig (Porcine) Perilipin 1 (PLIN1) interaction partners

  1. PLIN1 and PLIN2 (show PLIN2 Proteins) have been evaluated as candidate genes for growth, carcass and meat quality traits in pigs; two single-nucleotide polymorphisms, one in intron 2 of the PLIN1 gene (JN860199:g.173G>A) and the 3' untranslated region of the PLIN2 (show PLIN2 Proteins) gene (GU461317:g.98G>A); results obtained indicate that the PLIN2 (show PLIN2 Proteins) polymorphism could be a useful marker for lean growth.

  2. In pig muscle PLIN1 and PLIN2 (show PLIN2 Proteins) proteins are localized in correspondence with extra and intra-myocellular lipids, respectively.

  3. This work describes the cloning and sequencing of porcine PLIN and M6PRBP1 (show PLIN3 Proteins) cDNAs, the chromosome mapping of these two genes, as well as the expression pattern of porcine PAT genes.

PLIN1 Protein Profile

Protein Summary

The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene.

Gene names and symbols associated with Perilipin 1 Proteins (PLIN1)

  • perilipin 1 (PLIN1)
  • perilipin 1 (plin1)
  • perilipin (LOC692833)
  • perilipin 1 (Plin1)
  • perilipin-1-like (LOC100856637)
  • 6030432J05Rik protein
  • FPLD4 protein
  • LOC692833 protein
  • Peri protein
  • PERIA protein
  • perilipin protein
  • Plin protein

Protein level used designations for Perilipin 1 Proteins (PLIN1)

perilipin , perilipin 1 , perilipin-1-like , lipid droplet-associated protein , perilipin-1 , perilipin A , perilipin B , PERI , adipocyte lipid droplet binding protein

GENE ID SPECIES
467755 Pan troglodytes
594876 Xenopus (Silurana) tropicalis
692833 Bombyx mori
100036810 Xenopus laevis
100407311 Callithrix jacchus
100437952 Pongo abelii
5346 Homo sapiens
520598 Bos taurus
103968 Mus musculus
25629 Rattus norvegicus
654411 Sus scrofa
100135431 Ovis aries
415487 Gallus gallus
488735 Canis lupus familiaris
100728074 Cavia porcellus
100856637 Canis lupus familiaris
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