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Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta Proteins (PIK3C2B)

The protein encoded by PIK3C2B belongs to the phosphoinositide 3-kinase (PI3K) family. Additionally we are shipping PIK3C2B Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIK3C2B 289021  
PIK3C2B 5287 O00750
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Top PIK3C2B Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 16 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PIK3C2B Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , ,

More Proteins for Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta (PIK3C2B) Interaction Partners

Human Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta (PIK3C2B) interaction partners

  1. Class II enzyme PI3K-C2beta and the class IB isozyme p110gamma (show PIK3CG Proteins) mainly regulate the S1P (show MBTPS1 Proteins)- and high density lipoprotein (HDL (show HSD11B1 Proteins))-dependent endothelial cell (EC) migration and PI3K-C2alpha (show PIK3C2A Proteins) primarily controls EC survival

  2. Data suggest a novel role for nucleotide-free Ras in cell signaling in which PI3KC2beta stabilizes nucleotide-free Ras and that interaction of Ras and PI3KC2beta mutually inhibit one another.

  3. The results of this study showed that strong association between PIK3C2B gene alternation and high-grade oligodendroglial tumors.

  4. These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 (show RFP Proteins) as a previously undescribed negative regulator of CD4 (show CD4 Proteins) T cells.

  5. Overexpression of PIK3C2B is associated with esophageal squamous cell carcinoma.

  6. different human small cell lung carcinoma cell lines overexpress distinct subsets of PI3Ks, resulting in differences in signalling cascades activated by stem cell factor (show KITLG Proteins); insights into specificity and functional significance of PI3K (show PIK3CA Proteins) signalling in cancer

  7. activity of nuclear phosphoinositide 3-kinase C2beta investigated in HL-60 cells induced to differentiate along granulocytic or monocytic lineages

  8. identified the 185-kDa protein altered by nitrotyrosylation in platelets from patients with systemic sclerosis as phosphoinositide kinase C2beta (PI 3 (show PI3 Proteins)-K); the activity of PI 3 (show PI3 Proteins)-K increases in nitrotyrosylated platelet lystaes from patients with SSc (show CYP11A1 Proteins)

  9. Class II phosphoinositide 3-kinase C2beta isnot essential for epidermal differentiation

  10. Epidermal growth factor (show EGF Proteins) stimulates the appearance of PI3K-C2beta in nuclei.

PIK3C2B Protein Profile

Protein Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

Gene names and symbols associated with PIK3C2B

  • phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (Pik3c2b)
  • phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (PIK3C2B)
  • C2-PI3K protein

Protein level used designations for PIK3C2B

nuclear cap binding protein subunit 2 , phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta , phosphoinositide-3-kinase, class 2, beta polypeptide , PI3K-C2-beta , PI3K-C2beta , PTDINS-3-kinase C2 beta , phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide , phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta , phosphoinositide 3-kinase-C2-beta , ptdIns-3-kinase C2 subunit beta

289021 Rattus norvegicus
5287 Homo sapiens
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