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Pim-1 Oncogene Proteins (PIM1)

The protein encoded by PIM1 belongs to the Ser/Thr protein kinase family, and PIM subfamily. Additionally we are shipping PIM1 Antibodies (196) and PIM1 Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIM1 9361 P36776
PIM1 24649 P26794
PIM1 18712  
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Top PIM1 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details
Yeast Cat His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$739.20
Details

PIM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Rat (Rattus) ,

Mouse (Murine)

Top referenced PIM1 Proteins

  1. Human PIM1 Protein expressed in Escherichia coli (E. coli) - ABIN1098563 : Ionov, Le, Tunquist, Sweetenham, Sachs, Ryder, Johnson, Lilly, Kraft: Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects. in Anticancer research 2003 (PubMed)
    Show all 2 references for ABIN1098563

More Proteins for Pim-1 Oncogene (PIM1) Interaction Partners

Zebrafish Pim-1 Oncogene (PIM1) interaction partners

  1. Inhibition of the Pim1 oncogene (show RAB1A Proteins) results in diminished visual function.

Human Pim-1 Oncogene (PIM1) interaction partners

  1. demonstrate Pim1 as a novel kinase that is responsible for the phosphorylation of eNOS (show NOS3 Proteins) at Ser (show SIGLEC1 Proteins)-633 and enhances endothelial cells sprouting of aortic rings from diabetic mice

  2. Data suggest that combining PIM and JAK2 (show JAK2 Proteins) kinase inhibitors may offer a more efficacious therapeutic approach for myeloproliferative neoplasms (MPNs) over JAK2 (show JAK2 Proteins) inhibitor mono-therapy.

  3. A high percentage of urothelial carcinomas express Pim kinases. Pim expression differs in NILG, NIHG, and IHG lesions.

  4. Mutations of Lon (show LONP1 Proteins), which likely impair its chaperone properties, are at the basis of a genetic inherited disease named the cerebral, ocular, dental, auricular, skeletal (CODAS) syndrome. (Review)

  5. Downregulation of microRNA33a promotes the expression CDK6 (show CDK6 Proteins), CCND1 (show CCND1 Proteins), and PIM1, and gastric cancer cell proliferation.

  6. glycogen synthase kinase 3 beta (GSK3B) and the forkhead box P3 (FOXP3 (show FOXP3 Proteins)) transcription factors are direct PIM1 targets.

  7. Inhibition of Lon (show LONP1 Proteins) protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.

  8. By associating with PIM-1L, CD180 (show CD180 Proteins) can thus obtain autonomous signaling capabilities, and this complex is then channeling inflammatory signals into B cell survival programs

  9. Pim1 kinase activity maintains airway epithelial integrity and protects against house dust mite-induced proinflammatory activation of the airway epithelium.

  10. Pim-1 and Pim-3 (show PIM3 Proteins) enhance phosphorylation and cell surface expression of CXCR4 (show CXCR4 Proteins) in prostate cancer cells. PC-3 (show PCSK1 Proteins) prostate cancer cells overexpressing either Pim-1 or Pim-3 (show PIM3 Proteins) kinases form larger xenograft tumors than the parental PC-3 (show PCSK1 Proteins) cells.

Mouse (Murine) Pim-1 Oncogene (PIM1) interaction partners

  1. Pim1 kinase activity maintains airway epithelial integrity and protects against house dust mite-induced proinflammatory activation of the airway epithelium.

  2. Pim kinases prevent premature cardiac aging and maintain a healthy pool of functional mitochondria leading to efficient cellular energetics.

  3. Pim-1 kinase activity regulates hepatocyte growth factor (show HGF Proteins)-induced tumor cell migration, invasion, and cell scattering.

  4. these results identify Pim1 as a novel effector molecule sufficient to drive CD4 (show CD4 Proteins)( ) alphabeta T-cell development and survival in the absence of gammac cytokine receptor (show LEPR Proteins) signaling.

  5. Our data suggest that Pim1 might contribute to progression rather than initiation in prostate neoplasia.

  6. Loss of PIM1 is associated with abnormal hematopoietic phenotypes.

  7. Pim-1 activity prevents Drp1 compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to sI

  8. Pim1 kinase deletion and inhibition slows endothelial cell detachment by trypsinization and increases cell adhesion.

  9. Telomere elongation consistent with a young phenotype is observed following Pim-1 overexpression.

  10. demonstrated that over-expression of miR-16 (show GDE1 Proteins) mimics suppressed Pim-1 expression in FD-FLT3 (show FLT3 Proteins)/ITD cells suggesting that increased miR-16 (show GDE1 Proteins) expression contributes to depletion of Pim-1 after FLT3 (show FLT3 Proteins) inhibition

PIM1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

Gene names and symbols associated with Pim-1 Oncogene Proteins (PIM1)

  • pim-1 oncogene (PIM1)
  • pim-1 oncogene (pim1)
  • lon peptidase 1, mitochondrial (LONP1)
  • pim-1 oncogene (Pim1)
  • proviral integration site 1 (Pim1)
  • cb1068 protein
  • fj47b05 protein
  • hLON protein
  • LON protein
  • LonHS protein
  • LONP protein
  • PIM protein
  • Pim-1 protein
  • PIM1 protein
  • pim2 protein
  • pim3 protein
  • PRSS15 protein
  • wu:fj47b05 protein

Protein level used designations for Pim-1 Oncogene Proteins (PIM1)

proto-oncogene serine/threonine-protein kinase pim-1 , kinase pim-1 , proviral integration site 2 , serine/threonine-protein kinase Pim-1 , serine/threonine-protein kinase pim-2 , pim-1 oncogene , hLON ATP-dependent protease , lon protease homolog, mitochondrial , mitochondrial ATP-dependent protease Lon , mitochondrial lon protease-like protein , serine protease 15 , Oncogene PIM1 , pim-1 kinase 44 kDa isoform , pim-1 oncogene (proviral integration site 1) , serine/threonine-protein kinase pim-1 , non-specific serine/threonine protein kinase , proto-oncogene serine/threonine-protein kinase Pim-1 , proviral integration site 1

GENE ID SPECIES
100272002 Ovis aries
58054 Danio rerio
462656 Pan troglodytes
493494 Xenopus (Silurana) tropicalis
495516 Xenopus laevis
719232 Macaca mulatta
100053898 Equus caballus
9361 Homo sapiens
5292 Homo sapiens
24649 Rattus norvegicus
281402 Bos taurus
100858838 Gallus gallus
481772 Canis lupus familiaris
100157844 Sus scrofa
100724588 Cavia porcellus
493888 Felis catus
18712 Mus musculus
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