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Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) ELISA Kits

PKD1 encodes a member of the polycystin protein family. Additionally we are shipping Polycystic Kidney Disease 1 (Autosomal Dominant) Antibodies (58) and Polycystic Kidney Disease 1 (Autosomal Dominant) Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PKD1 5310 P98161
PKD1 18763 O08852
Anti-Rat PKD1 PKD1 24650  
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Top Polycystic Kidney Disease 1 (Autosomal Dominant) ELISA Kits at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 7.81 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests Log in to see 11 to 13 Days
$910.56
Details
Mouse
  96 Tests Log in to see 11 to 13 Days
$1,029.60
Details

More ELISA Kits for Polycystic Kidney Disease 1 (Autosomal Dominant) Interaction Partners

Human Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. These results suggest that the Ser (show SIGLEC1 ELISA Kits) at the 4166 site in PC1 (show PCSK1 ELISA Kits) is crucial in the PC1 (show PCSK1 ELISA Kits) mediated MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits)/myc (show MYC ELISA Kits) signaling pathway, which might be the key pathophysiological cause of Aortic dissection.

  2. Novel PKD1 mutations in Chinese autosomal dominant polycystic kidney disease patients

  3. The pathogenic mutation in PKD1 linked pedigree was c.8522G>A (p.E2771K) in exon 23. This C to T transition occurs at the CpG dinucleotides which is the known hotspot point for mutations.

  4. Germline mutations in PKD1 gene is associated with autosomal-dominant polycystic kidney disease.

  5. Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy.

  6. PCs expression and p53 (show TP53 ELISA Kits) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.

  7. These results suggest that, at least in some patients, the severity of the cystic disease is inversely correlated with the level of polycystin 1 function.

  8. Overexpression of PKD1 in a prostate cancer cell line model resulted in decreased cell proliferation and epithelial mesenchymal transition.

  9. and MMP9 (show MMP9 ELISA Kits) expression in PKD1 constitutively-active MD-MB-231 cells and MCF-7 knockdown cells were decreased and increased respectively

  10. A substantial number of PKD1 missense or synonymous mutations characterize pre-mRNA splicing. One missense and 2 synonymous mutations induce significant defects in pre-mRNA splicing.

Mouse (Murine) Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. kd1 mutant mice have transcriptional profiles consistent with changes in lipid metabolism and distinct metabolite and complex lipid profiles in kidneys. .. cells lacking Pkd1 have an intrinsic fatty acid oxidation defect and that manipulation of lipid content of mouse chow modifies cystic disease.

  2. Polycystin 1 was overexpressed in M1 cells, no increase in any of these parameters was detected

  3. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA ELISA Kits) effect on MVB secretory traffic.

  4. detected a marked increase in the localization of beta-catenin (show CTNNB1 ELISA Kits) in the nucleus of crypt epithelial cells in the ileum of PKD1

  5. PKD1 phosphorylates AMPKalpha2 (show PRKAA2 ELISA Kits) at Ser485/491, thus diminishing AMPK (show PRKAA1 ELISA Kits) activity.

  6. These data potentially explain the severe renal manifestations of the tuberous sclerosis/polycystic kidney disease contiguous gene syndrome and open new perspectives for the use of mTOR (show FRAP1 ELISA Kits) inhibitors in PKD (show PRKD1 ELISA Kits).

  7. Our results show that AKAP13 (show AKAP13 ELISA Kits)-PKD1 signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.

  8. PKD1 acts downstream of TGFalpha and Kras, to mediate formation of ductal structures through activation of the Notch (show NOTCH1 ELISA Kits) pathway.

  9. Results reveal that whereas protein kinase D1 (show PRKD1 ELISA Kits) and protein kinase D2 (show PKD2 ELISA Kits) are essential for neuronal polarity, there exists a functional redundancy between the two proteins.

  10. PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.

Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antigen Profile

Antigen Summary

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Gene names and symbols associated with PKD1

  • polycystic kidney disease 1 (autosomal dominant) (PKD1) antibody
  • polycystic kidney disease 1 homolog (Pkd1) antibody
  • polycystic kidney disease 1 homolog (human) (Pkd1) antibody
  • protein kinase D1 (Prkd1) antibody
  • mFLJ00285 antibody
  • PBP antibody
  • Pc-1 antibody
  • PC1 antibody
  • Pkcm antibody
  • PKD antibody
  • PKD1 antibody
  • Prkcm antibody
  • TRPP1 antibody

Protein level used designations for PKD1

polycystic kidney disease 1 (autosomal dominant) , polycystin 1 , autosomal dominant polycystic kidney disease 1 protein , polycystic kidney disease-associated protein , polycystin-1 , transient receptor potential cation channel, subfamily P, member 1 , polycystic kidney disease protein 1 , autosomal dominant polycystic kidney disease 1 protein homolog , polycystic kidney disease 1 homolog; polycystin-1 , nPKC-D1 , nPKC-mu , protein kinase C mu type , protein kinase C, mu , protein kinase D , serine/threonine-protein kinase D1

GENE ID SPECIES
416553 Gallus gallus
749291 Pan troglodytes
5310 Homo sapiens
606755 Canis lupus familiaris
100516429 Sus scrofa
18763 Mus musculus
24650 Rattus norvegicus
18760 Mus musculus
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