PKD1 Products
(Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
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This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008].
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Featured PKD1 Categories
PKD1 Antibodies
High quality antibodies with extensive validation data.
PKD1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PKD1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PKD1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7163832
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, WB, IHC (p), FACS, IF (cc), IF (p), IHC (fro), ICC
Validations
- (4)
- (1)
Cat. No.
ABIN678083
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7238054
Quantity
200 μL
Datasheet
Datasheet
Recommended PKD1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969448
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN6200495
Quantity
96 tests
Datasheet
Datasheet
Recommended PKD1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3086170
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3086171
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3086172
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PKD1 products
: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." in: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." in: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).
: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).
: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." in: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).
Synonyms and alternative names related to PKD1
polycystin 1, transient receptor potential channel interacting (PKD1), polycystin 1, transient receptor poteintial channel interacting (Pkd1), polycystin 1, transient receptor potential channel interacting (Pkd1), polycystin-1 (LOC749291), mFLJ00285, PBP, Pc-1, PC1, TRPP1Protein level used designations for PKD1
- autosomal dominant polycystic kidney disease 1 protein
- polycystic kidney disease-associated protein
- polycystin 1
- polycystin-1
- transient receptor potential cation channel, subfamily P, member 1
- autosomal dominant polycystic kidney disease 1 protein homolog
- polycystic kidney disease 1 homolog; polycystin-1
- polycystic kidney disease 1 (autosomal dominant)
- polycystic kidney disease protein 1
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