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PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Additionally we are shipping PBX1 Antibodies (72) and PBX1 Proteins (6) and many more products for this protein.
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these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions.
the PBX1 binding motif at its promoter acted to positively regulate STAT3 (show STAT3 ELISA Kits) transcription.
Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4 (show CD4 ELISA Kits)(+) T cell effector function
Notably, PBX1 and NFE2L1 (show NFE2L1 ELISA Kits) levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 (show NFE2L1 ELISA Kits) levels increases damage by oxidative stress in human midbrain cells.
PBX1 overexpression in MCF10A cells up-regulated most LiMe (show LIME1 ELISA Kits) genes.
results indicate that E2A (show TCF3 ELISA Kits)-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A (show TCF3 ELISA Kits) fusion genes to develop B-lineage ALL
Review of the role of the E2A (show TCF3 ELISA Kits)-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
This study thus suggests that RNF6 (show RNF6 ELISA Kits) overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 (show RNF6 ELISA Kits) axis can be developed as a novel therapeutic target of leukemia.
Data identifies PBX1 amplification as a functional hallmark of aggressive ERalpha (show ESR1 ELISA Kits)-positive breast cancers.
We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3 (show TCF3 ELISA Kits)-PBX1 as well as an enrichment of genes involved in immunity and infection pathways in ETV6 (show ETV6 ELISA Kits)-RUNX1 (show RUNX1 ELISA Kits) subtype
findings suggest that pbx1 may be required during the late stage of swim bladder development
MEIS2 (show MEIS2 ELISA Kits) associates with chromatin-bound PBX1, recruits PARP1/ARTD1 (show PARP1 ELISA Kits), and initiates PARP1 (show PARP1 ELISA Kits)-mediated eviction of H1 from the chromatin fiber.
Hoxa2 (show HOXA2 ELISA Kits), Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 (show HMX1 ELISA Kits) expression.
PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2 (show MEIS2 ELISA Kits).
FLT3 (show FLT3 ELISA Kits)-ITD is capable of inhibiting FLT3 (show FLT3 ELISA Kits)-ITD+ cell proliferation through the p21/Pbx1 axis
Both histone H3 (show HIST3H3 ELISA Kits) lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.
Thus, PTBP1 (show PTBP1 ELISA Kits) controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.
Pbx1-dependent control of VMC (show PLXNA3 ELISA Kits) differentiation kinetics underlies gross renal vascular patterning.
Results thus show how Pbx1 controls Fgf10 (show FGF10 ELISA Kits) in the developing lung.
These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
homeobox protein PBX1
, homeobox protein PRL
, pre-B-cell leukemia transcription factor 1
, pre-B-cell leukemia transcription factor 1b
, pre B-cell leukemia transcription factor 1
, Homeobox protein pbx1