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PBX1 Products

(Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].

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Featured PBX1 Categories

PBX1 Antibodies

High quality antibodies with extensive validation data.

PBX1 ELISA Kits

Reliable ELISA kits for a wide range of species.

PBX1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PBX1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (5)
  • (5)
Cat. No. ABIN562114
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC
Validations
  • (3)
Cat. No. ABIN7164137
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN571168
Quantity 100 μg
Datasheet Datasheet

Recommended PBX1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1149119
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1149118
Quantity 96 tests
Datasheet Datasheet

Recommended PBX1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124544
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314106
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
Cat. No. ABIN5954421
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PBX1 products

DellOrso, Wang, Shih, Saso, Berghella, Gutierrez-Cruz, Ladurner, OShea, Sartorelli, Zare: "The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1." in: Cell reports, Vol. 14, Issue 5, pp. 1156-1168, (2016) (PubMed).

Nguyen, Barozzi, Faronato, Lombardo, Steel, Patel, Darbre, Castellano, Győrffy, Woodley, Meira, Patten, Vircillo, Periyasamy, Ali, Frige, Minucci, Coombes, Magnani: "Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion." in: Nature communications, Vol. 6, pp. 10044, (2015) (PubMed).

Petrini, Wang, Zucali, Lee, Pham, Voeller, Meltzer, Giaccone: "Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 8, pp. 1960-71, (2013) (PubMed).

Bjerke, Hyman-Walsh, Wotton: "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1." in: Molecular and cellular biology, Vol. 31, Issue 18, pp. 3723-33, (2011) (PubMed).

Magnani, Ballantyne, Zhang, Lupien: "PBX1 genomic pioneer function drives ER? signaling underlying progression in breast cancer." in: PLoS genetics, Vol. 7, Issue 11, pp. e1002368, (2011) (PubMed).

Cheung, Chan, Chan, Ikegawa, Kou, Ngai, Smith, Luk, Huang, Mori, Sham, Kung: "Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation." in: Human molecular genetics, Vol. 18, Issue 4, pp. 679-87, (2009) (PubMed).

Horman, Velu, Chaubey, Bourdeau, Zhu, Paul, Gebelein, Grimes: "Gfi1 integrates progenitor versus granulocytic transcriptional programming." in: Blood, Vol. 113, Issue 22, pp. 5466-75, (2009) (PubMed).

Duesing, Charpentier, Marre, Tichet, Hercberg, Balkau, Froguel, Gibson: "Evaluating the association of common PBX1 variants with type 2 diabetes." in: BMC medical genetics, Vol. 9, pp. 14, (2008) (PubMed).

Park, Shih, Wang: "Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer." in: Cancer research, Vol. 68, Issue 21, pp. 8852-60, (2008) (PubMed).

Qiu, Tomita, Zhang, Nakamichi, Morii, Aozasa: "Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth." in: The American journal of pathology, Vol. 170, Issue 1, pp. 152-9, (2007) (PubMed).

Synonyms and alternative names related to PBX1

PBX homeobox 1 (PBX1), pre-B-cell leukemia homeobox 1a (pbx1a), pre B cell leukemia homeobox 1 (Pbx1), PBX homeobox 1 (Pbx1), pre-B-cell leukemia homeobox 1 S homeolog (pbx1.S), 2310056B04Rik, AI848790, AU015730, D230003C07Rik, fi29e01, Pbx-1, Pbx1a, PBX1A, pbx1b, Pbx1b, wu:fi29e01, Xpbx1, Xpbx1b, zgc:55265

Protein level used designations for PBX1

  • homeobox protein PBX1
  • homeobox protein PRL
  • pre-B-cell leukemia transcription factor 1
  • pre-B-cell leukemia transcription factor 1b
  • pre B-cell leukemia transcription factor 1
  • Homeobox protein pbx1
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