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anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Antibodies

PAPPA encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Additionally we are shipping PAPPA Kits (42) and PAPPA Proteins (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PAPPA 18491 Q8R4K8
PAPPA 313262  
PAPPA 5069 Q13219
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Top anti-PAPPA Antibodies at

Showing 10 out of 411 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IA, IP, ELISA, WB Western Blot: PAPP A Antibody (4G11) [ABIN268232] - Detection of htPAPP-A in Native human PAPP-A (PAPP-A/proMBP complex). Sandwich ELISA: PAPP A Antibody (4G11) [ABIN268232] - Calibration curves for two PAPP- A sandwich immunoassays. (A) 4G11 3C8 and (B) 4G11 10H9. Capture MAb: 4G11 (biotinylated) Detection MAbs: 3C8 or 10H9 (labeled with stable Eu3+ -chelate) Antigen: htPAPP-A 0.1 mg Log in to see 5 to 7 Days
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 4 to 6 Days
Human Mouse Un-conjugated IA, IP, ELISA 0.2 mg Log in to see 5 to 7 Days
Human Mouse Un-conjugated IP, ELISA, WB 0.2 mg Log in to see 5 to 7 Days
Human Mouse Un-conjugated WB Western Blot: Pappalysin-1/PAPP-A Antibody (18A10) [ABIN2612839] - A - SDS-PAGE analysis in reducing conditions of human recombinant dPAPP-A and tissue (purified from atherosclerotic plaques) dPAPP-A. Lane 1: human htPAPP-A Lane 2: recombinant dPAPP-A Lane 3: tissue dPAPP-A Gel staining: Coomassie brilliant blue R-250 Comments: proMBP subunit released from htPAPP-A upon reduction is not stained by Coomassie brilliant blue because of high degree of glycosylation. B - Western blotting analysis of PAPP-A purified from atherosclerotic tissue. For immunostaining mixture of anti-PAPP-A MAbs 18A10 (Cat # ABIN2612839), 7A6(Cat # ABIN2612830) and 3C8 (Cat # ABIN261283) Lanes are noted as in Fig.4A 0.2 mg Log in to see 5 to 7 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti PAPPA Polyclonal Antibody, Unconjugated (ABIN718931) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: PAPP A Antibody (PAPP A 1-1) [NBP2-21614] - Human placenta tissue. 0.1 mL Log in to see 5 to 7 Days
Human Mouse Un-conjugated PrA, ELISA   1 mg Log in to see 4 to 5 Days
Human Mouse Un-conjugated PrA, ELISA, WB   1 mg Log in to see 4 to 5 Days
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days

PAPPA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,
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Rat (Rattus) , ,

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Human , , , ,
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Top referenced anti-PAPPA Antibodies

  1. Human Monoclonal PAPPA Primary Antibody for IA, IP - ABIN268232 : Pan, Hanada, Zhao, Mao, Ma: Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo. in PLoS ONE 2012 (PubMed)

More Antibodies against PAPPA Interaction Partners

Mouse (Murine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A.

  2. stimulation of PAPP-A expression by intermittent PTH (show PTH Antibodies) treatment contributes to PTH (show PTH Antibodies) bone anabolism in mice

  3. PAPP-A affects fascicle structure, thereby affecting tendon phenotype.

  4. PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps (show CAPS Antibodies) in the brachiocephalic artery

  5. these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor (show INSR Antibodies) signaling

  6. Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation.

  7. absence of PAPP-A is associated with resistance to the development of indicators of diabetic nephropathy in mice

  8. Pregnancy-associated plasma protein (PAPP)-A expressed in the mammary gland controls epithelial cell proliferation and differentiation.

  9. Data conclude that PAPP-A proteolytic activity is required for the lesion-promoting effect of PAPP-A and that its specificity must be directed against IGFBP-4 (show IGFBP4 Antibodies).

  10. observations revealed a novel function of prohibitin (show PHB Antibodies) as a chaperone of p53 (show TP53 Antibodies). Further, they suggest that binding of denatured p53 (show TP53 Antibodies) in intron 1 causes an enhancer effect and increases the transcription of PAPP-A

Human Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. Data suggest that stanniocalcin 1 (show STC1 Antibodies) and 2 (STC1 (show STC1 Antibodies), STC2 (show STC2 Antibodies)) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis.

  2. measurements of maternal serum PAPP-A concentration in the first trimester predict severe fetal growth restriction more effectively than they predict a birth weight below the 10th percentile among a Chinese population

  3. Women with PAPP-A PAPP-A >/=90th percentile is protective against small for gestational age, and is associated with an increased risk of large for gestational age for infants born after 32 weeks gestation.

  4. Data suggest that incidences of intrauterine growth restriction, pre-eclampsia, preterm birth, and fetal death are significantly greater in pregnant women with low serum levels of PAPP-A in first trimester (9-13 weeks of pregnancy) as compared to control pregnant women; study was conducted in India.

  5. The first trimester maternal PAPP-A levels were decreased in the ICSI group compared with those in the controls, but not in IVF (show SCN5A Antibodies) and embryo transfer groups.

  6. miR (show MLXIP Antibodies)-141 may play important roles in ox-LDL-induced abnormal proliferation of the vascular smooth muscle cells by targeting PAPPA.

  7. Combined analysis of PAPP-A and free beta-hCG (show CGA Antibodies) appears to be a potential candidate to predict early fetal loss.

  8. PAPP-A in ascites and tissue-associated PAPP-A serve to increase IGF bioactivity and, thereby, to stimulate IGF-IR-mediated ovarian tumor growth.

  9. PAPP-A determination during the first trimester of pregnancy in women at risk for IUGR makes possible the prophylactic treatment and monitoring of pregnancy.

  10. Data indicate that rising pregnancy-associated plasma protein-A (PAPP-A) levels are prognostic in patients with coronary artery disease (CAD (show CAD Antibodies)).

Cow (Bovine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. study determined IGFR1 (show IGF1R Antibodies) and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Antibodies)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 (show IGF1R Antibodies) expression and PAPP-A secretion as a modulator of IGF1 (show IGF1 Antibodies) in cattle with COD (show SNRPB Antibodies)

  2. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 (show IGFBP2 Antibodies) degradation

  3. concluded that changes in granulosa cell PAPP-A mRNA levels do not occur during final preovulatory follicular development in cattle

PAPPA Antigen Profile

Protein Summary

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.

Gene names and symbols associated with PAPPA

  • pregnancy-associated plasma protein-A (PAPP-A) antibody
  • pregnancy-associated plasma protein A (Pappa) antibody
  • pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) antibody
  • pregnancy-associated plasma protein A, pappalysin 1 (Pappa) antibody
  • 8430414N03Rik antibody
  • ASBABP2 antibody
  • DIPLA1 antibody
  • IGFBP-4ase antibody
  • PAG1 antibody
  • PAPA antibody
  • PAPP-A antibody
  • Pappa antibody
  • PAPPA1 antibody

Protein level used designations for PAPPA

IGF-dependent IGFBP-4 protease , insulin-like growth factor-dependent IGF-binding protein 4 protease , pappalysin-1 , aspecific BCL2 ARE-binding protein 2 , differentially placenta 1 expressed protein , insulin-like growth factor-dependent IGF binding protein-4 protease , pregnacy-associated plasma protein A , PAPPA-like protein , pregnancy-associated plasma protein A-like protein , cleaves insulin-like binding protein-4 (IGFBP-4) , metalloprotease

100033920 Equus caballus
18491 Mus musculus
313262 Rattus norvegicus
5069 Homo sapiens
481692 Canis lupus familiaris
282647 Bos taurus
100734958 Cavia porcellus
417245 Gallus gallus
397219 Sus scrofa
443157 Ovis aries
Selected quality suppliers for anti-PAPPA (PAPPA) Antibodies
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