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The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Additionally we are shipping Prostaglandin E Synthase Kits (22) and Prostaglandin E Synthase Proteins (6) and many more products for this protein.
Showing 10 out of 60 products:
Human Polyclonal Prostaglandin E Synthase Primary Antibody for IHC, IHC (p) - ABIN4347784
Camacho, Dilmé, Solà-Villà, Rodríguez, Bellmunt, Siguero, Alcolea, Romero, Escudero, Martínez-González, Vila: Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm. in Journal of lipid research 2013
Show all 4 Pubmed References
Human Polyclonal Prostaglandin E Synthase Primary Antibody for IHC (p), WB - ABIN537285
Nakanishi, Menoret, Tanaka, Miyamoto, Montrose, Vella, Rosenberg: Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity. in Cancer prevention research (Philadelphia, Pa.) 2011
COX-2 (show COX2 Antibodies) and mPGES-1-dependent synthesis of PGE2 contributes to a dedifferentiated aortic smooth muscle cell phenotype.
Several studies provide evidence that the expression of mPGES1 is regulated by a number of transcriptional factors and inducible in conditions of inflammation and hypoxia.[review]
The Genome Wide Area Study, using a phenotyping algorithm for asthma for data mining electronic medical records, identified four asthma susceptibility loci: 6p21.31, 9p21.2, and 10q21.3 in the European American population; and the prostaglandin synthase E gene (PTGES) at 9q34.11 in African Americans. Biologic support exists for genes at the 9p21.2 and 9q34.11 loci TEK (show TEK Antibodies), encoding the endothelial tyrosine in animal studies.
C-myc (show MYC Antibodies) regulates mPGES1 expression by binding to the proximal promoter. C-myc (show MYC Antibodies) transfection in HeLa cells up-regulates mPGES1 mRNA and protein expression.
COX-2 (show COX2 Antibodies) and mPGES-1 have roles in arachidonic acid regulation of inflammatory prostaglandin E2 biosynthesis
The identified amino acid residues can act as target sites for the design and development of drug candidates against mPGES-1
These findings support the value of a prognostic and predictive role for mPGES1.
Data show that statins limit hepatic myofibroblasts proliferation via a cyclooxyegnase-2 (COX-2 (show COX2 Antibodies)) and microsomal PGE (show LIPF Antibodies) synthase-1 (mPGES-1) dependent pathway.
Data show that cyclooxygenase2 (COX2 (show COX2 Antibodies))overexpression induces prostaglandin E synthase (PTGES) through early growth response 1 (EGR1 (show EGR1 Antibodies)) in colorectal cancer cell lines.
mPGES-1 is downregulated via EGR1 (show EGR1 Antibodies) and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes
that mPGES-1 exerts a potentially protective effect against renal fibrosis and inflammation induced by unilateral ureteral obstruction in mice
In line with the acetyltransferase activity of p300 (show NOTCH1 Antibodies), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Antibodies) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Antibodies) to its gene
The findings suggest that COX-2 (show COX2 Antibodies)/mPGES-1/PGE2 axis could be activated by albumin (show ALB Antibodies) in the proximal tubular cells via a NLRP3 (show NLRP3 Antibodies) inflammasome-mediated mechanism and could thus contribute to proteinuria-related renal tubular cell injury.
mPGES-1 overexpression prevents Fas (show FAS Antibodies)-induced hepatocyte apoptosis and liver injury through activation of Akt (show AKT1 Antibodies) .
The expression of Lcn2 (show LCN2 Antibodies) and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS (show TLR4 Antibodies)), indicating that Lcn2 (show LCN2 Antibodies) mediates LPS (show TLR4 Antibodies)-induced inflammation. These findings shed light on the role of Lcn2 (show LCN2 Antibodies) during decidualization.
The results show that mPges-1 may be a direct downstream target gene of the P4 receptor (show PGR Antibodies).
mPges-1 depletion modestly increased thrombogenesis in LDL-receptor (show LDLR Antibodies) knockout mice. This response was markedly further augmented by coincident deletion of the I prostanoid receptor.
Data (including data from studies in knockout mice) suggest interactions of cholinergic/prostaglandin systems participate in neuroimmunomodulation; microsomal Ptges-1 is part of cholinergic anti-inflammatory response in chronic inflammatory diseases.
Prostacyclin synthase (show PTGIS Antibodies) and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Gas6 (show GAS6 Antibodies), through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2 (show PTGS2 Antibodies)), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
Prostaglandin E synthase interacts with inducible heat shock protein 70 (show HSPA1A Antibodies) after heat stress in bovine primary dermal fibroblast cells.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF Antibodies)) and Fas (show FAS Antibodies) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (show HSP90AA1 Antibodies) (heat shock 90 kD protein 1 alpha).
PGES pathway is responsible for the endometrial production of PGE (show LIPF Antibodies)(2) in the bovine endometrium during the estrous cycle
This study showed that COX-1 (show PTGS1 Antibodies) and COX-2 (show PTGS2 Antibodies) in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.
microsomal prostaglandin E synthase-1
, prostaglandin E synthase
, MGST1-like 1
, glutathione S-transferase 1-like 1
, microsomal glutathione S-transferase 1-like 1
, microsomal prostaglandin E synthase 1
, p53-induced apoptosis protein 12
, p53-induced gene 12 protein
, tumor protein p53 inducible protein 12